Gut Microbiota Modulation of Dementia Related Complications DOI Creative Commons

Xiaoqing Su,

Yinghua Chen, Xingxing Yuan

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based medicine. One most extensively studied biological pathways is gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies dysbiosis suggest complex behavioral changes, such as alterations sociability and anxiety, can be modulated through microbiota. Specifically, mental disorders include major depression, bipolar disorder, schizophrenia. Gastrointestinal diseases reversed by modulating Dementia its related mechanisms are also amenable modulation This review focuses on role microbiota dementia discussing effects depressive symptoms, cognitive function, mood, chronic stress, prospects microbiota-gut-brain axis for dementia. Although animal models revealed promising approaches treating microbiota, it may premature incorporate these interventions into standard clinical practice. The heterogeneity findings trials randomized control yet convincingly demonstrate efficacy reversing complications.

Language: Английский

Gut Microbiota Modulation of Dementia Related Complications DOI Creative Commons

Xiaoqing Su,

Yinghua Chen, Xingxing Yuan

et al.

Aging and Disease, Journal Year: 2025, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2025

Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based medicine. One most extensively studied biological pathways is gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies dysbiosis suggest complex behavioral changes, such as alterations sociability and anxiety, can be modulated through microbiota. Specifically, mental disorders include major depression, bipolar disorder, schizophrenia. Gastrointestinal diseases reversed by modulating Dementia its related mechanisms are also amenable modulation This review focuses on role microbiota dementia discussing effects depressive symptoms, cognitive function, mood, chronic stress, prospects microbiota-gut-brain axis for dementia. Although animal models revealed promising approaches treating microbiota, it may premature incorporate these interventions into standard clinical practice. The heterogeneity findings trials randomized control yet convincingly demonstrate efficacy reversing complications.

Language: Английский

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