Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis DOI Creative Commons
Suqi Liu, Qian Xi,

Xuannian Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 31, 2025

Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an unknown origin and complex pathogenic mechanisms. A deeper understanding of these mechanisms essential for effective treatment. Pulmonary associated the senescence alveolar type II epithelial (ATⅡ) cells. Additionally, ATⅡ can lead to senescence-associated secretory phenotype, which affects cellular communication disrupts lung tissue repair, contributing development IPF. The role mitochondrial dysfunction in senescence-related diseases increasingly recognized. It induce through apoptosis, impaired autophagy, disrupted energy metabolism, potentially playing key IPF progression. This article explores therapeutic potential targeting dysfunction, emphasizing their significant roles pathogenesis.

Language: Английский

Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis DOI Creative Commons
Suqi Liu, Qian Xi,

Xuannian Li

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 31, 2025

Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an unknown origin and complex pathogenic mechanisms. A deeper understanding of these mechanisms essential for effective treatment. Pulmonary associated the senescence alveolar type II epithelial (ATⅡ) cells. Additionally, ATⅡ can lead to senescence-associated secretory phenotype, which affects cellular communication disrupts lung tissue repair, contributing development IPF. The role mitochondrial dysfunction in senescence-related diseases increasingly recognized. It induce through apoptosis, impaired autophagy, disrupted energy metabolism, potentially playing key IPF progression. This article explores therapeutic potential targeting dysfunction, emphasizing their significant roles pathogenesis.

Language: Английский

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