Metabolic Reprogramming at the Edge of Redox: Connections Between Metabolic Reprogramming and Cancer Redox State

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 498 - 498

Published: Jan. 9, 2025

The importance of redox systems as fundamental elements in biology is now widely recognized across diverse fields, from ecology to cellular biology. Their connection metabolism particularly significant, it plays a critical role energy regulation and distribution within organisms. Over recent decades, has emerged relevant focus studies biological regulation, especially following its recognition hallmark cancer. This shift broadened cancer research beyond strictly genetic perspectives. interaction between carcinogenesis involves the essential metabolic pathways, such glycolysis Krebs cycle, well involvement redox-active components like specific amino acids cofactors. feedback mechanisms linking highlight development patterns that enhance flexibility adaptability tumor processes, influencing larger-scale phenomena circadian rhythms epigenetics.

Language: Английский

Deciphering the Regulatory Potential of Antioxidant and Electron-Shuttling Bioactive Compounds in Oolong Tea

Biology, Journal Year: 2025, Volume and Issue: 14(5), P. 487 - 487

Published: April 28, 2025

OT has gained attention for its high polyphenol content and therapeutic potential. To elucidate this further, study investigated the electron-shuttling bioactive compounds of evaluated their effect on dysregulated breast cancer (BC) genes. extracts were obtained via solvent extraction (SE) supercritical fluid (SFE), followed by in vitro assays. Phytochemical analysis revealed that ethanol-extracted (OTL-E) had highest polyphenol, flavonoid, tannin contents, correlating with strong antioxidant activity, while water-extracted (OTL-W) exhibited greater bioelectricity-stimulating properties microbial fuel cells (MFC), confirmed cyclic voltammetry (CV). Based phytochemical analyses, SE displayed a better technique isolating compared to SFE. In silico approaches through network pharmacology, molecular docking dynamics simulations polyphenols ortho- or para-dihydroxyl groups targeted BC proteins involved kinase signaling, apoptosis, hormone receptor pathways. Luteolin binding affinities MAPK1 PIK3CA free energy (ΔG) −9.1 −8.4 kcal/mol, respectively. Trajectory-based analyses enthalpy-favored ligand-induced conformational changes these oncoproteins, altering function development. These findings suggest potential as chemopreventive agent, warranting further vivo validation.

Language: Английский