Impact of Preoperative Glucagon‐Like Peptide‐1 Receptor Agonist on Outcomes Following Major Surgery

World Journal of Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are increasingly being used for the management of diabetes mellitus and obesity. We sought to define impact preoperative GLP‐1RA use on outcomes following major surgical procedures. Methods Patients who underwent a procedure between 2013 2021 were identified using IBM MarketScan database. took within year before surgery categorized as “exposed.” After propensity score matching (PSM), multivariable regression analysis was association exposure with postoperative complications. Results Among 138,980 patients (coronary artery bypass graft: n = 39,516, 28.4%; pneumonectomy: 4,881, 3.5%; abdominal aortic aneurysm repair: 4,459, 3.3%; pancreatectomy: 15,873, 11.4%; colectomy: 74,251, 53.4%), most individuals male ( 80,871, 58.2%) median age 58 (IQR 53–61) years. 2944 (2.2%) had surgery. Overall incidence complications 36.5% 50,724); included sepsis 6,385, 4.6%), site infections 7,431, 5.3%), thromboembolism 3,609, 2.6%), pneumonia 4,783, 3.4%), renal 9,017, 6.5%), or cardiopulmonary failure 26,661, 19.2%). On unmatched analysis, higher risk (no GLP‐1RA: 36.3% vs. 44.5% p < 0.001); however, after PSM account measured confounders, not associated odds (OR 0.99 95% CI 0.91–1.08; > 0.05). during 2 weeks 522, 17.7%), there no (nonrecent 44.7% recent 44.1%; 0.992). Conclusions an increased

Language: Английский

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Perioperative and periprocedural management of GLP-1 receptor-based agonists and SGLT2 inhibitors: narrative review and the STOP-GAP and STOP DKA-2 algorithms

Current Medical Research and Opinion, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Jan. 28, 2025

The GLP-1 receptor-based agonists (GLP-1RAs) and SGLT2 inhibitors (SGLT2i) are major twenty first century breakthroughs in diabetes obesity medicine but there important safety considerations regarding the perioperative periprocedural management of individuals who treated with these agents. GLP-1RAs have been linked to an increased risk retained gastric contents pulmonary aspiration while SGLT2i can be associated diabetic ketoacidosis. This manuscript provides a narrative review available evidence for risks people prescribed SGLT2i. authors provide expert opinion-driven recommendations algorithms on how safely manage under perioperative/periprocedural settings.

Language: Английский

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Trends, Demographics, and Outcomes for Glucagon-Like Peptide-1 Receptor Agonist Use in Total Knee Arthroplasty: An 11-Year Perspective

The Journal of Arthroplasty, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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GLP-1 Agonists for Weight Loss: Do They Increase Complications in Non-Diabetic Patients Undergoing Primary Total Hip Arthroplasty?

The Journal of Arthroplasty, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Association between glucagon‐like peptide‐1 receptor agonist use and peri‐operative pulmonary aspiration: a systematic review and meta‐analysis

Anaesthesia, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Summary Introduction Glucagon‐like peptide‐1 receptor agonists are known to delay gastric emptying; however, the association between glucagon‐like agonist use and peri‐operative pulmonary aspiration risk is not known. This systematic review meta‐analysis aimed summarise evidence on whether exposure associated with or increased residual content in fasted patients undergoing procedures requiring anaesthesia sedation. Methods We searched six databases for studies assessing contents volunteers who were using any form of agonist. Pooled odds ratios estimated each outcome random effects meta‐analysis. Certainty was assessed GRADE framework. Results Of 9010 screened studies, 28 observational included. In a nine involving 304,060 481 cases aspiration, (OR 1.04, 95%CI 0.87–1.25, low certainty evidence). 18 165,522 3831 contents, an despite appropriate fasting (odds ratio 5.96, 3.96–8.98, five 1706 208 withholding at least one dose before procedure lower 0.51, 0.33–0.81, very Discussion Patients presenting though available does indicate that this translates aspiration.

Language: Английский

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Impact of Glucagon-Like Peptide-1 Receptor Agonists on Postoperative Outcomes Following Ankle Fracture Open Reduction and Internal Fixation

The Journal of Foot & Ankle Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Perioperative management of patients taking glucagon-like peptide 1 receptor agonists: Society for Perioperative Assessment and Quality Improvement (SPAQI) multidisciplinary consensus statement

British Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Readmissions at Thirty-Days and One-Year for Implant-Associated Complications following Primary Total Hip and Knee Arthroplasty: A Population-Based Study of 34,392 Patients Across Austria

The Journal of Arthroplasty, Journal Year: 2024, Volume and Issue: 40(2), P. 301 - 309.e3

Published: Aug. 29, 2024

The primary aim of this study was to assess 30-day and 1-year rates for unplanned readmission due implant-associated complications following total hip (THA) or knee arthroplasty (TKA) in Austria. Secondary endpoints were reasons differences revision risk depending on demographics hospital size. Data patients receiving THA (n = 18,508) TKA 15,884) orthopaedic trauma units across Austria within a period (January 2021 December 2021) retrieved from government-maintained database. absolute relative frequencies readmissions calculated. Risk factors investigated. any complication 1.0% (339 34,392) 3.0% (1,024 34,392), respectively. Relative the overall rate at 30 days 1,952) 1 year 12,109), 17.4 8.5%, higher (1.2%) than (0.8%; P 0.001), while it opposite (THA, 2.7%; TKA, 3.3%; < 0.001). Mechanical (554 1,024) most common reason readmission. Prolonged length in-hospital stay independently associated with increased patients. Treatment large-sized hospitals are lower reported other countries, similar Considering that almost 20% joint attributable complications, optimization postdischarge medical care these is warranted.

Language: Английский

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Utilization of Glucagon-Like Peptide-1 Receptor Agonist at the Time of Total Hip Arthroplasty for Patients Who Have Morbid Obesity

The Journal of Arthroplasty, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Perceived Risk of Elective Total Hip Arthroplasty: A Brazilian Hip Society Survey

The Journal of Arthroplasty, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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