Association Between Glucagon-like Peptide-1 Receptor Agonist Use and Perioperative Aspiration: A Systematic Review and Meta-Analysis

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are known to slow gastric emptying, however the association between GLP-1 RA use and perioperative aspiration risk is not known. This systematic review meta-analysis aimed summarise evidence on whether exposure associated with (1) pulmonary in patients undergoing procedures requiring anaesthesia or sedation, (2) increased residual contents among fasted patients. Methods: A search of MEDLINE, EMBASE, Web Science, Cochrane Central ClinicalTrials.gov WHO ICTRP registries (updated 13 Jan 2025), citation tracking included studies was performed (14 2025). Studies assessing who were using any form included. Data extracted independently duplicate. Pooled odds ratios (ORs) estimated for each outcome random effect meta-analysis. Certainty assessed Grading Recommendations Assessment, Development, Evaluation framework. Results: Of 9,010 screened studies, 28 observational analysis. In a 9 involving 304,060 individuals 481 cases aspiration, GLP-1RA (OR, 1.04; 95% CI, 0.87-1.25, low certainty evidence). 18 165,522 3,831 contents, positively despite appropriate fasting 5.96; 3.96-8.98, 5 1,706 208 withholding at least one dose prior procedure lower 0.51; 0.33-0.81, very No measured time since last aspiration. Conclusions: Patients GLP-1RAs heightened presenting surgery though available does indicate that this translates an elevated Further research needed evaluate risks benefits different strategies managing these medications during period.

Language: Английский

The Impact of GLP-1 Receptor Agonists on Postoperative Outcomes Following Total Shoulder Arthroplasty

Seminars in Arthroplasty JSES, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский