Effect of vitamin D on anterior cruciate ligament injury rates and post‐reconstruction function—A systematic review

Journal of Experimental Orthopaedics, Journal Year: 2025, Volume and Issue: 12(2)

Published: April 1, 2025

Abstract Purpose This systematic review aimed to investigate the association between serum vitamin D levels and key outcomes following anterior cruciate ligament reconstruction (ACLR), including ACL injury risk, postoperative muscle recovery post‐reconstruction functional outcomes. Methods We conducted a comprehensive search across five databases (Cochrane Library, EMBASE, MEDLINE, Scopus Web of Science) until July 2024. Studies were selected based on specific inclusion criteria, such as studies evaluating relationship ACLR strength. Risk bias was assessed using MINORS tool, results synthesized narratively due study heterogeneity. Results Five with 656,243 participants met criteria. Most reported that low associated significantly increased risk injuries poorer strength recovery. However, evidence regarding bone health inconsistent. No meta‐analysis variability designs outcomes, but qualitative synthesis indicated potential protective role in Conclusions Vitamin deficiency appears increase impede post‐surgery. limitations include high inconsistent underscoring need for further research. The registered PROSPERO (ID: CRD42024584483). Level Evidence III, review.

Language: Английский

Vitamin D Deficiency after Anterior Cruciate Ligament Reconstruction Associates with Knee Osteoarthritis: A Retrospective Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 3029 - 3029

Published: Sept. 8, 2024

Background/Objectives: The objective of this study was to test the hypothesis that vitamin D deficiency (i.e., serum 25-hydroxyvitamin (25(OH)D) ≤ 20 ng/mL) associates with increased occurrence and shortened time a knee osteoarthritis (OA) diagnosis after anterior cruciate ligament reconstruction (ACLR). Methods: This consisted retrospective, case-control design. inclusion criteria (1) patients (≥18 y) who underwent arthroscopic ACLR (cases; n = 28) without (controls; 56) subsequent OA (≥90 d from date ACLR) (2) documented 25(OH)D concentration (and before for cases). Controls were matched (2:1) cases based on sex, age at ACLR, body mass index. After matching, separated into two groups: deficient (serum or non-vitamin > ng/mL). Data extracted medical records. Results: Thirty-one percent (n 26) included deficient. Fifty 13) twenty-six 15) subsequently diagnosed (p 0.03). Time significantly 0.02) decreased in (OA-free interval, 95% confidence interval [CI] 7.9 10.9 compared group CI 10.5 12.5 y). Conclusions: Vitamin may serve as prognostic biomarker following ACLR.

Language: Английский