International Journal of Environmental Research and Public Health,
Journal Year:
2018,
Volume and Issue:
15(9), P. 1944 - 1944
Published: Sept. 6, 2018
Dyslipidemia
is
commonly
associated
with
diabetes
(T2DM).
This
has
been
demonstrated
for
the
Caucasian
population,
but
few
data
are
available
Asian
Indians.
The
paper
aims
to
investigate
serum
lipids
(separately
or
in
combination)
and
their
association
glucose
intolerance
status
(T2DM
prediabetes)
a
rural
Bangladeshi
population.
A
sample
of
2293
adults
(≥20
years)
were
included
community
based
cross-sectional
survey
2009.
Anthropometric
measures,
blood
pressure,
(fasting
2-h
oral
tolerance
test)
fasting
(total
cholesterol,
T-Chol;
triglycerides,
Tg;
low
density
lipoprotein
LDL-C
high
HDL-C)
registered.
Analysis
covariance
(ANCOVA)
regression
analysis
performed.
High
Tg
levels
seen
26%
64%
participants,
depending
on
status.
Low
HDL-C
all
groups
(>90%).
Significant
linear
trends
observed
T-Chol,
increasing
(p
trend
<0.001).
T2DM
was
significantly
T-Chol
(Odds
ratio
(OR):
2.43,
p
<
0.001),
(OR:
3.91,
0.001)
2.17,
=
0.044).
Prediabetes
showed
significant
1.96,
2.93,
0.011).
Participants
combined
had
12.75-fold
higher
OR
4.89
prediabetes.
In
Indian
populations
an
assessment
warranted
not
only
patients,
also
those
European Heart Journal,
Journal Year:
2019,
Volume and Issue:
41(1), P. 111 - 188
Published: Aug. 31, 2019
The
ESC/EAS
Guidelines
represent
the
views
of
ESC
and
EAS,
were
produced
after
careful
consideration
scientific
medical
knowledge,
evidence
available
at
time
their
publication.The
EAS
is
not
responsible
in
event
any
contradiction,
discrepancy,
and/or
ambiguity
between
other
official
recommendations
or
guidelines
issued
by
relevant
public
health
authorities,
particular
relation
to
good
use
healthcare
therapeutic
strategies.Health
professionals
are
encouraged
take
fully
into
account
when
exercising
clinical
judgment,
as
well
determination
implementation
preventive,
diagnostic,
strategies;
however,
do
override,
way
whatsoever,
individual
responsibility
make
appropriate
accurate
decisions
each
patient's
condition
consultation
with
that
patient
and,
where
necessary,
caregiver.Nor
exempt
from
taking
full
updated
competent
order
manage
case
light
scientifically
accepted
data
pursuant
respective
ethical
professional
obligations.It
also
professional's
verify
applicable
rules
regulations
relating
drugs
devices
prescription.
European Heart Journal,
Journal Year:
2016,
Volume and Issue:
37(39), P. 2999 - 3058
Published: Aug. 27, 2016
The
Task
Force
for
the
Management
of
Dyslipidaemias
European
Society
Cardiology
(ESC)
and
Atherosclerosis
(EAS)
Developed
with
special
contribution
Assocciation
Cardiovascular
Prevention
&
Rehabilitation
(EACPR)
ABI
:
ankle-brachial
index
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(5), P. 1835 - 1835
Published: March 6, 2020
Diabetes
mellitus
comprises
a
group
of
carbohydrate
metabolism
disorders
that
share
common
main
feature
chronic
hyperglycemia
results
from
defects
insulin
secretion,
action,
or
both.
Insulin
is
an
important
anabolic
hormone,
and
its
deficiency
leads
to
various
metabolic
abnormalities
in
proteins,
lipids,
carbohydrates.
Atherosclerosis
develops
as
result
multistep
process
ultimately
leading
cardiovascular
disease
associated
with
high
morbidity
mortality.
Alteration
lipid
risk
factor
characteristic
atherosclerosis.
Possible
links
between
the
two
depending
on
altered
pathways
have
been
investigated
numerous
studies.
It
was
shown
both
types
diabetes
can
actually
induce
atherosclerosis
development
further
accelerate
progression.
Elevated
glucose
level,
dyslipidemia,
other
alterations
accompany
are
tightly
involved
pathogenesis
at
almost
every
step
atherogenic
process.
Chronic
inflammation
currently
considered
one
key
factors
present
starting
earliest
stages
pathology
initiation.
may
also
be
regarded
possible
mellitus.
However,
data
available
so
far
do
not
allow
for
developing
effective
anti-inflammatory
therapeutic
strategies
would
stop
atherosclerotic
lesion
progression
reduction.
In
this
review,
we
summarize
aspects
possibly
affect
relationship
inflammation.
We
discuss
established
pathophysiological
features
link
mellitus,
such
oxidative
stress,
protein
kinase
signaling,
role
certain
miRNA
epigenetic
modifications.
Current Opinion in Lipidology,
Journal Year:
2016,
Volume and Issue:
27(5), P. 473 - 483
Published: Aug. 9, 2016
Today,
it
is
no
longer
a
hypothesis,
but
an
established
fact,
that
increased
plasma
concentrations
of
cholesterol-rich
apolipoprotein-B
(apoB)-containing
lipoproteins
are
causatively
linked
to
atherosclerotic
cardiovascular
disease
(ASCVD)
and
lowering
LDL
reduces
events
in
humans.
Here,
we
review
evidence
behind
this
assertion,
with
emphasis
on
recent
studies
supporting
the
'response-to-retention'
model
-
namely,
key
initiating
event
atherogenesis
retention,
or
trapping,
apoB-containing
within
arterial
wall.New
clinical
trials
have
shown
ezetimibe
anti-PCSK9
antibodies
both
nonstatins
lower
ASCVD
events,
they
do
so
same
extent
as
would
be
expected
from
comparable
by
statin.
These
demonstrate
beyond
any
doubt
causal
role
atherogenesis.
In
addition,
laboratory
experimentation
human
Mendelian
randomization
revealed
novel
information
about
critical
New
has
also
emerged
mechanisms
for
accumulation
harmful
triglyceride-rich
remnant
states
overnutrition.
Like
LDL,
these
lipoprotein
remnants
become
retained
modified
wall,
causing
atherosclerosis.LDL
other
cholesterol-rich,
lipoproteins,
once
cause
atherosclerosis.
This
simple,
robust
pathophysiologic
understanding
may
finally
allow
us
eradicate
ASCVD,
leading
killer
world.
Journal of Molecular Cell Biology,
Journal Year:
2016,
Volume and Issue:
8(2), P. 101 - 109
Published: March 18, 2016
Obesity-linked
type
2
diabetes
is
one
of
the
paramount
causes
morbidity
and
mortality
worldwide,
posing
a
major
threat
on
human
health,
productivity,
quality
life.
Despite
great
progress
made
towards
better
understanding
molecular
basis
diabetes,
available
clinical
counter-measures
against
insulin
resistance,
defect
that
central
to
obesity-linked
remain
inadequate.
Adiponectin,
an
abundant
adipocyte-secreted
factor
with
wide-range
biological
activities,
improves
sensitivity
in
target
tissues,
modulates
inflammatory
responses,
plays
crucial
role
regulation
energy
metabolism.
However,
adiponectin
as
promising
therapeutic
approach
has
not
been
thoroughly
explored
context
pharmacological
intervention,
extensive
efforts
are
being
devoted
gain
mechanistic
signaling
its
regulation,
reveal
targets.
Here,
we
discuss
tissue-
cell-specific
functions
adiponectin,
emphasis
pathways,
potential
crosstalk
between
other
pathways
involved
metabolic
regulation.
Understanding
just
why
how
downstream
effector
molecules
work
will
be
essential,
together
empirical
trials,
guide
us
therapies
root
cause(s)
resistance.
