Beyond LDL cholesterol: remnant cholesterol is associated with cardiometabolic risk factors in children

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

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Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 17, 2025

This study aimed to examine the relationships between remnant cholesterol (RC) and risk of aortic aneurysm dissection (AAD). prospective cohort included 368,139 European adults from UK Biobank. Additionally, causal relationship RC AAD was investigated using Mendelian randomization (MR) analyses. During a median follow-up 13.65 years, 1,634 cases abdominal (AAA), 698 thoracic (TAA), 184 (AD) were identified. Elevated levels associated with an increased AAA compared reference group ([highest vs. lowest levels]: adjusted hazard ratio (HR) = 1.65, 95% CI: 1.36–1.99). However, no significant association observed high either TAA or AD. Two-sample MR analyses supported effect on (odds (OR) 2.08, 1.70–2.56). The persisted after adjusting for effects RC-associated genetic variants low-density lipoprotein (LDL-C). In contrast, did not indicate any associations linked greater developing AAA, confirming relationship. These findings suggest that may function as new biomarker could be integral strategies at preventing AAA.

Language: Английский

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Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: implications for clinical trials

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2023, Volume and Issue: 27(2), P. 125 - 135

Published: Nov. 21, 2023

Purpose of review Atherosclerotic cardiovascular disease (ASCVD) is the leading cause death despite development effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part residual ASCVD risk. Interestingly, coexistence both high can further increase risk ASCVD. The aim this to describe role inflammation, separately combined, in Recent findings Results from recently published studies, including observational genetic Mendelian randomization support a causal relationship between on primary secondary prevention settings. In addition, current evidence studies suggests that increases Summary suggest combined with may confer particular for Attention dual threat necessary, research field warranted. effect cholesterol-lowering drugs anti-inflammatory alone remains be elucidated. Video abstract http://links.lww.com/COCN/A20

Language: Английский

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Separate and Joint Associations of Remnant Cholesterol Accumulation and Variability With Carotid Atherosclerosis: A Prospective Cohort Study

Journal of the American Heart Association, Journal Year: 2023, Volume and Issue: 12(14)

Published: July 14, 2023

Background We aimed to examine separate and joint associations of remnant cholesterol (RC) accumulation variability with the risk carotid atherosclerosis (CAS) in general population. Methods Results A total 6213 participants who underwent 3 sequential health examinations during 2010 2015 were enrolled followed up until December 31, 2021. Cumulative RC (cumRC) among visits exposure interest our study. Adjusted Cox models performed calculate hazard ratio (HR) 95% CI. C‐statistics, integrated discrimination improvement, net reclassification index used estimate incremental predictive ability. During a median follow‐up 4.00 years, 2613 developed CAS. Higher cumRC (HR, 1.33 [95% CI, 1.17–1.52]) greater 1.22 1.08–1.39]) significantly associated elevated CAS, independent traditional cardiovascular factors low‐density lipoprotein cholesterol. Participants divided into 4 groups according assess their associations. Compared “low low variability,” “high high variability” had highest by variability.” Finally, assessment effect on value CAS versus single‐time‐point measures RC. Conclusions Excessive levels each independently higher incidence coexistence could further yield risks.

Language: Английский

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The U-shaped association between remnant cholesterol and risk of all-cause and cardiovascular deaths in diabetic adults: Findings from NHANES 1999–2018

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: 34(10), P. 2282 - 2288

Published: May 12, 2024

Language: Английский

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Remnant Cholesterol and Cardiovascular and All-cause Mortality in Korean Adults

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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Longitudinal Association of Remnant Cholesterol With Cognitive Decline Varies by Lipid‐Lowering Drugs: A Population‐Based Cohort Study

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Background Although the association between remnant cholesterol (RC) and cognitive impairment has been reported, of RC with decline remains scarce. Also, role lipid‐lowering therapy in is unclear. The study aimed to examine longitudinal associations by drug use during follow‐up. Methods Results used data from Wave 2 (2004–2005) 8 (2016–2017) ELSA (English Longitudinal Study Ageing). Global functions at baseline (Wave 2) follow‐up (Waves 3–8) were assessed integrating 3 domains: memory capacity, semantic fluency, orientation. Multivariate‐adjusted linear mixed models employed associations, results presented as β (95% CI) SD/year. Of 5053 participants ultimately included, 55.4% female mean age (SD) was 65.7 (9.3) years. Per 1 mmol/L increment significantly associated a faster rate ( =−0.010 SD/year [95% CI −0.019 −0.001]). Furthermore, we observed that pattern only non‐lipid‐lowering group =−0.019 CI, −0.031 −0.007]) but not =0.007 −0.006 0.020]), significant interaction P =0.015). Similar findings for domains. Conclusions Higher levels steeper decline. drugs might mitigate this These underscore importance early monitoring proactive management clinical practice.

Language: Английский

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Higher remnant cholesterol is associated with an increased risk of amnestic mild cognitive impairment: a community-based cross-sectional study

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Feb. 12, 2024

Background and aims Amnestic mild cognitive impairment (aMCI) is the most common subtype of MCI, which carries a significantly high risk transitioning to Alzheimer’s disease. Recently, increasing attention has been given remnant cholesterol (RC), non-traditional previously overlooked factor. The aim this study was explore association between plasma RC levels aMCI. Methods Data were obtained from Brain Health Cognitive Management Team in Wuhan ( https://hbtcm.66nao.com/admin/ ). A total 1,007 community-dwelling elders recruited for project. Based on ten tools including general demographic data, screening some exclusion scales, these participants divided into aMCI n = 401) normal groups 606). Physical examinations conducted all participants, with clinical indicators such as blood pressure, sugar, lipids collected. Results group had higher compared (0.64 ± 0.431 vs. 0.52 0.447 mmol/L, p < 0.05). Binary logistics regression revealed that occupation P <0.001, OR 0.533, 95%CI: 0.423–0.673) 0.014, 1.477, 95% CI:1.081–2.018) associated factors Partial correlation analysis, after controlling occupation, showed significant negative MoCA scores r 0.059, 0.046), well Naming 0.070, 0.026). ROC curve analysis demonstrated an independent predictive efficacy predicting (AUC 0.580, 0.544 ~ 0.615, 0.001). Conclusion Higher identified indicator aMCI, particularly naming domain among older individuals. Further longitudinal studies are necessary validate RC.

Language: Английский

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Elevated remnant cholesterol and non-HDL cholesterol concentrations from real-world laboratory results: a cross-sectional study in Southeast Asians

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Feb. 7, 2024

Introduction Triglyceride-rich remnant lipoproteins (TRLs) are considered atherogenic due to the presence of cholesterol, which is transported by apolipoprotein B. In clinical practice, concentration TRLs can be estimated calculating cholesterol or non-HDL levels. Aim This study aims investigate proportion patients who have low LDL (LDL-C) but elevated concentration, stratified hypertriglyceridaemia and ethnicity, using real-world hospital data. Our secondary aim with levels guideline-recommended goals. Methods A 2-year retrospective was conducted at a single centre, analyzing lipid blood tests all patients, including directly measured LDL-C. Fasting for not mandatory. Results The included total 21,605 consecutive plasma profiles analyzed in our laboratory. median age 61 years. ASCVD ( n = 14,704), 23.7% had an LDL-C level <1.8 mmol/L, 11.3% concentrations ≥0.65 48.8% were non-high-density lipoprotein (non-HDL-C) goal (<2.6 mmol/L). Among diagnosed atherosclerotic cardiovascular disease (ASCVD) mmol/L 3,484), only 11.9% high 96% also achieved recommended non-HDL-C target <2.6 mmol/L. When mean 0.214 when triglyceride <1.7 3,380), vs. 0.70 724), p < 0.001. ≥1.7 <.8 there 254 71 suboptimal Malays higher compared both Chinese Indians across levels, particularly hypertriglyceridaemia. Conclusions An >0.65 present 11% patients. current goal, uses 0.8 estimate >92% suggesting that it unlikely clinically useful majority patient population except where concomitant Further studies needed establish appropriate calculated paired otherwise, Southeast Asian population.

Language: Английский

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Association Between Remnant Cholesterol and Risk of Incident Atrial Fibrillation: Population‐Based Evidence From a Large‐Scale Prospective Cohort Study

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(10)

Published: May 18, 2024

Evidence for the relationship between remnant cholesterol (RC) and incident atrial fibrillation (AF) risk remains sparse limited.

Language: Английский

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