Role of long noncoding RNAs in diabetes-associated peripheral arterial disease DOI Creative Commons
Alonso Tapia, Xuejing Liu, Naseeb Kaur Malhi

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 24, 2024

Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical

Language: Английский

Innovative Approaches in Atherosclerosis Treatment: Harnessing Traditional Chinese Medicine to Target Long Non-Coding RNAs DOI
Xiaofang Chen,

Wen‐yan Ding,

Yifan Liu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156488 - 156488

Published: Feb. 9, 2025

Language: Английский

Citations

0
Host Long Noncoding RNAs as Key Players in Mycobacteria–Host Interactions DOI Creative Commons

Stephen K. Kotey,

Xuejuan Tan,

Audrey L. Kinser

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2656 - 2656

Published: Dec. 21, 2024

Mycobacterial infections, caused by various species within the Mycobacterium genus, remain one of main challenges to global health across world. Understanding complex interplay between host and mycobacterial pathogens is essential for developing effective diagnostic therapeutic strategies. Host long noncoding RNAs (lncRNAs) have emerged as key regulators in cellular response bacterial infections cells. This review provides an overview intricate relationship lncRNAs context tuberculosis non-tuberculous mycobacterium (NTM) infections. Accumulation evidence indicates that play a critical role regulating infection cells, such macrophages, primary cells intracellular survival. The expression specific has been implicated pathogenesis providing potential targets development novel host-directed therapies biomarkers TB diagnosis. In summary, this aims highlight current state knowledge regarding involvement It also emphasizes their application targets.

Language: Английский

Citations

2
Role of long noncoding RNAs in diabetes-associated peripheral arterial disease DOI Creative Commons
Alonso Tapia, Xuejing Liu, Naseeb Kaur Malhi

et al.

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: July 24, 2024

Abstract Diabetes mellitus (DM) is a metabolic disease that heightens the risks of many vascular complications, including peripheral arterial (PAD). Various types cells, but not limited to endothelial cells (ECs), smooth muscle (VSMCs), and macrophages (MΦs), play crucial roles in pathogenesis DM-PAD. Long non-coding RNAs (lncRNAs) are epigenetic regulators important cellular function, their dysregulation DM can contribute PAD. This review focuses on developing field lncRNAs emerging linking We studies investigating role processes contributing DM-PAD, those ECs, VSMCs, MΦ. By examining intricate molecular landscape governed by these relevant cell types, we hope shed light EC dysfunction, inflammatory responses, remodeling Additionally, provide an overview research approach methodologies, from identifying disease-relevant characterizing functions context also discuss potential leveraging diagnosis therapeutics for Collectively, this provides summary lncRNA-regulated DM-PAD highlights translational lncRNA biology tackle increasingly prevalent complex disease. Graphical

Language: Английский

Citations

1