Impact of insulin resistance and microvascular ischemia on myocardial energy metabolism and cardiovascular function: pathophysiology and therapeutic approaches
Cardiovascular Endocrinology & Metabolism,
Journal Year:
2025,
Volume and Issue:
14(2)
Published: April 16, 2025
Insulin
resistance
(IR)
and
microvascular
ischemia
together
result
in
cardiovascular
dysfunction
by
impairing
the
heart’s
energy
balance.
IR
cardiomyocytes
disrupts
glucose
metabolism,
leading
to
deficits
that
can
drive
cardiac
hypertrophy
heart
failure.
Microvascular
exacerbates
these
effects
limiting
oxygen
nutrient
delivery,
intensifying
oxidative
stress,
mitochondrial
dysfunction,
cell
death.
also
reduces
effectiveness
of
vasodilators
like
nitroglycerin
sodium
nitroprusside,
exacerbating
endothelial
thus
delivery
during
ischemia.
This
combination
heightens
risk
left
ventricular
Understanding
interactions
is
critical
for
developing
targeted
therapies
improve
outcomes
patients
with
ischemic
disease.
study
examines
relationship
between
IR,
ischemia,
myocardial
a
focus
on
clinical
management
therapeutic
strategies.
Language: Английский
Effects of Vibroacoustic Stimulation on Psychological, Physiological, and Cognitive Stress
Sensors,
Journal Year:
2024,
Volume and Issue:
24(18), P. 5924 - 5924
Published: Sept. 12, 2024
Global
stress
is
widespread
in
today's
post-pandemic
world
of
political
and
economic
uncertainty.
Vibroacoustic
technology
a
vibrotactile
intervention
with
multiple
uses,
but
its
impact
on
lacks
interpretation.
This
research
assessed
if
the
vibroacoustic
Sound
Massage
(VSM)
can
reduce
psychological,
physiological,
cognitive
stress.
The
Perceived
Stress
Scale
(PSS-10)
electrocardiogram
(ECG)
electroencephalogram
(EEG)
biosignals
were
used
to
quantify
results.
Participants
divided
into
Low-Stress
High-Stress
groups.
ECG
results
show
VSM
increased
parasympathetic
activity
for
all
participants,
group
being
more
affected.
EEG
indicate
concentration,
reduced
arousal,
relaxation,
participant
well-being
non-significantly
affected,
though
variability
this
metric
was
homogenised
after
VSM.
Together,
these
validate
as
an
effective
support
tool
management;
however,
further
required.
Language: Английский
The Neural Basis of Interoception
Springer eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 75 - 104
Published: Jan. 1, 2024
Language: Английский
Neurocardiology: Major mechanisms and effects
Journal of Electrocardiology,
Journal Year:
2024,
Volume and Issue:
88, P. 153836 - 153836
Published: Nov. 22, 2024
Language: Английский
The role of the dorsomedial hypothalamus in the cardiogenic sympathetic reflex in the Sprague Dawley rat
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 24, 2024
Myocardial
ischemia
causes
the
production
and
release
of
metabolites
such
as
bradykinin,
which
stimulates
cardiac
spinal
sensory
afferents,
causing
chest
pain
an
increase
in
sympathetic
activity
referred
to
cardiogenic
afferent
reflex.
While
brain
stem
nuclei,
nucleus
tractus
solitarius
rostral
ventrolateral
medulla,
are
essential
reflex,
role
other
supramedullary
nuclei
reflex
not
clear.
The
dorsomedial
hypothalamic
(DMH)
is
involved
cardiovascular
regulation
plays
important
response
stressful
stimuli.
In
this
study,
we
determined
DMH
To
do
measured
arterial
pressure,
heart
rate,
renal
nerve
(RSNA)
responses
epicardial
bradykinin
(10
μg/mL)
anesthetized
Sprague
Dawley
rats
before
after
bilateral
microinjection
(50
nL)
either
GABAA
agonist
muscimol
(0.5
nmol)
inhibit
or
antagonist
bicuculline
(40
pmol)
disinhibit
activity.
Muscimol
inhibition
elicited
a
modest,
albeit
significant,
reduction
basal
pressure
rate
attenuated
bradykinin.
However,
it
did
change
magnitude
Bicuculline
disinhibition
increased
RSNA
but
augment
These
results
suggest
that
derived
from
does
play
rats.
Language: Английский
Effects of Vibroacoustic Stimulation on Psychological, Physiological and Cognitive Stress
Published: June 4, 2024
Global
stress
is
widespread
in
todays
post-pandemic
world
of
political
and
economic
uncertainty.
Vibroacoustic
technology
a
vibrotactile
intervention
with
multiple
uses,
its
impact
on
lacks
interpretation.
This
research
assessed
if
the
vibroacoustic
Sound
Massage
(VSM)
can
reduce
psychological,
physiological
cognitive
stress.
The
Perceived
Stress
Scale
(PSS-10),
electrocardiogram
(ECG)
electroencephalogram
(EEG)
biosignals
were
used
to
quantify
results.
Participants
divided
into
Low
High
groups.
ECG
results
show
VSM
increased
parasympathetic
activity
for
all
participants,
group
more
effected.
EEG
indicate
concentration
(TBR),
reduced
arousal
relaxation
(BAR),
non-significant
effects
participant
well-being
(FAA),
though
variability
this
metric
was
homogenised
after
VSM.
Together,
these
validate
as
an
effective
support
tool
management
further
required.
Language: Английский
An Algorithm for Initial Localization of Feature Waveforms Based on Differential Analysis Parameter Setting and Its Application in Clinical Electrocardiograms
Electronics,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2996 - 2996
Published: July 29, 2024
In
a
biological
signal
analysis
system,
signals
of
the
same
type
may
exhibit
significant
variations
in
their
feature
waveforms.
Biological
are
typically
weak,
which
increases
complexity
analysis.
Furthermore,
clinical
biomedical
susceptible
to
various
interferences
from
human
body
itself,
including
muscle
movements,
respiration,
and
heartbeat.
These
interference
factors
further
escalate
difficulty
Therefore,
precise
targeted
preprocessing
is
often
required
before
analyzing
these
enhance
accuracy
reliability
subsequent
extraction
classification.
Here,
we
have
established
an
effective
practical
algorithm
model
that
integrates
with
initial
localization
target
waveforms,
achieving
following
four
objectives:
1.
Determining
periodic
positions
2.
Preserving
original
amplitude
shape
waveforms
while
eliminating
negative
interference.
3.
Reducing
or
other
input
signal.
4.
Decreasing
noise
signal,
such
as
baseline
drift,
powerline
interference,
artifacts
commonly
found
signals.
We
validated
on
electrocardiogram
(ECG)
data
authoritative
MIT-BIH
open-source
ECG
database
demonstrating
its
effectiveness
reliability.
Language: Английский