Toxins, Journal Year: 2024, Volume and Issue: 16(11), P. 452 - 452
Published: Oct. 22, 2024
Arthritis has a high global prevalence. During the early ancient human era, bee (
Language: Английский
Autoimmunity Reviews, Journal Year: 2023, Volume and Issue: 22(6), P. 103326 - 103326
Published: March 22, 2023
Language: Английский
Citations
94
Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(2)
Published: Feb. 3, 2024
Abstract Background While an association between gut microbiota composition and thyroid cancer (TC) has been observed, the directionality causality of this relationship remain unclear. Methods We conducted a bidirectional two-sample Mendelian randomization (MR) analysis to investigate causal effect TC. Gut data were derived from diverse population encompassing various ethnicities ( n = 18,340 samples), while TC sourced European 218,792 samples). Instrumental variables, represented by single nucleotide polymorphisms (SNPs), employed assess using multiple MR methods, including inverse-variance weighting (IVW), weighted median, mode, MR-Egger, simple mode. F-statistics sensitivity analyses performed evaluate robustness findings. Results Our investigation identified comprehensive set 2934 instrumental variables significantly linked p < 1 × 10 - 5 ). The illuminated notable candidates within phylum Euryarchaeota, families Christensenellaceae Victivallaceae, genera Methanobrevibacter, Ruminococcus2, Subdoligranulum, which emerged as potential risk factors for On other hand, protective influence against was attributed class Betaproteobacteria, family FamilyXI, Anaerofilum, Odoribacter, Sutterella, alongside order Burkholderiales. Further enhancing our insights, integration 7 ) disclosed regulatory one five genera. Notably, genus Coprobacter innocuum group 0.012, OR 0.944) exhibited highest probability regulation. meticulous remained free significant bias, heterogeneity, or horizontal pleiotropy concerns. Conclusion Through approach, we elucidated Specific microbial taxa associated with increased conferred protection These findings advance understanding complex interplay pathogenesis, offering new insights into therapeutic modulating managing
Language: Английский
Citations
5
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 21, 2024
Abstract As an autoimmune disease, up to 73% of patients with primary biliary cholangitis (PBC) have a combination extrahepatic diseases (EHAIDs); however, the causal relationship between PBC and EHAIDs is unclear. The genome-wide association analyses provided 14 GWAS data for EHAIDs, bidirectional, two-sample MR were performed examine EHAIDs. analysis using provides strong meaningful estimation bidirectional correlation 7 EHAIDs: rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, sclerosis, hypothyroidism, inflammatory bowel disease ulcerative colitis its types. In addition, increases risk thyroid such as hyperthyroidism Graves' well multiple sclerosis psoriasis. Additionally, identified factor Crohn's Celiac disease. Based on genetic evidence, there may be connections specific not all coexisting induce PBC, vice versa. This underscores significance prioritizing in clinical practice. if any liver function abnormalities are observed during treatment or it crucial consider possibility comorbid PBC.
Language: Английский
Citations
5
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(2), P. e0298225 - e0298225
Published: Feb. 9, 2024
Background An association between primary biliary cholangitis (PBC) and connective tissue diseases (CTDs) [rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), sclerosis (SSc)] has been found in observational studies. However, the direction causality is unclear. The aim of this study was to assess PBC CTDs promote early screening, pre-emptive therapy, accurate stratification. Methods A two-sample Mendelian randomization (MR) analysis performed causal relationship [Genome-Wide Association Study (GWAS) meta-analysis, 8021 cases/16498 controls], SLE (GWAS cases/16489 controls), RA(FinnGen, 6236 cases/14727 SS(FinnGen, 2495 cases/365533 SSc (FinnGen, 302 cases/213145 controls). Inverse variance weighting (IVW) used as method, supplemented by four sensitivity analyses robustness results. Results IVW revealed that genetically predicted increased risk [odd’s ratio (OR) = 1.43, 95% confidence interval (CI) 1.30–1.58, P < 0.001]), RA (OR 1.09, 95%CI1.04–1.14, P<0.001), SS 1.18, 95%CI1.12–1.24, but not SSc. In addition, no observed an exposure PBC. Sensitivity did reveal horizontal pleiotropy. Conclusions Our provided new genetic evidence for a CTDs. SLE, RA, SS. findings highlighted importance active screening intervention patients with
Language: Английский
Citations
4
Biotechnology and Genetic Engineering Reviews, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 16
Published: May 23, 2023
The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) significantly associated with 13 diseases were extracted from summary statistics European genome-wide association studies (GWAS), their effects examined by Inverse variance-weighted (IVW) in a large GWAS on CeD. Finally, reverse MR performed CeD traits. Following application Bonferroni correction for multiple testing, genetically determined seven are causally CeD: Crohn's (CD) (OR [95%CI] = 1.156 [1.106 ± 1.208], P 1.27E-10), primary biliary cholangitis (PBC) (1.229 [1.143 1.321], 2.53E-08), sclerosing (PSC) (1.688 [1.466 1.944], 3.56E-13), rheumatoid arthritis (RA) (1.231 [1.154 1.313], 2.74E-10), systemic lupus erythematosus (SLE) (1.127 [1.081 1.176], 2.59E-08), type 1 diabetes (T1D) (1.41 [1.238 1.606], 2.24E-07), asthma (1.414 [1.137 1.758], 1.86E-03). IVW analysis indicated that increased risk diseases: CD (1.078 [1.044 1.113], 3.71E-06), Graves' (GD) (1.251 [1.127 1.387], 2.34E-05), PSC (1.304 [1.227 1.386], 8.56E-18), psoriasis (PsO) (1.12 [1.062 1.182], 3.38E-05), SLE (1.301[1.22 1.388], 1.25E-15), T1D (1.3[1.228 1.376], 1.57E-19), (1.045 [1.024 1.067], 1.82E-05). sensitivity analyses deemed results reliable without pleiotropy. There positive genetic correlations various CeD, latter also affects predisposition population.
Language: Английский
Citations
10
All Life, Journal Year: 2025, Volume and Issue: 18(1)
Published: Feb. 20, 2025
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(8), P. e41484 - e41484
Published: Feb. 21, 2025
Observational studies suggest that interstitial cystitis/bladder pain syndrome (IC/BPS) indices might be influenced by autoimmune diseases (AIDs), though it is difficult to infer causal relationships based on observational data due risk of residual confounding. We utilized Mendelian randomization (MR) explore relevance multiple AIDs IC/BPS. Our bidirectional two-sample MR analysis was summary statistics from the most recent and comprehensive genome-wide association studies. This particular approach used delve into cause effect between IC/BPS a group 14 AIDs. examined range such as ulcerative colitis, Crohn disease, celiac Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus, sclerosis, primary biliary cirrhosis, psoriasis, asthma, eczema, ankylosing spondylitis, type 1 diabetes, sclerosing cholangitis. analytical involved using inverse variance weighting method establish across various conditions. Furthermore, we carried out additional examinations, utilizing weighted median technique, MR-Egger regression, MR-PRESSO, evaluating reverse causality, in order strengthen dependability our results. findings indicate strong genetically predicted asthma developing with odds ratio 1.692, confidence interval 1.147 2.496, P = .008, while Cochran Q test .589 intercept .554, MR-PRESSO global .600. No evidence found for other Individuals show an increased vulnerability according findings. More randomized controlled trials are necessary validate these These results underscore importance healthcare providers assess potential patients, offering novel genetic perspective studying cystitis.
Language: Английский
Citations
0
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: March 26, 2025
Patients with diabetic nephropathy (DN) often present lipid profile abnormalities. While associations between these parameters and DN have been suggested, confounding factors obscure causal relationships. This study employed bidirectional Mendelian randomization (MR) to explore links. Using genome-wide association (GWAS) data, the primary analysis used inverse-variance weighted (IVW) method, which was supported by MR-Egger regression a median estimator (WME). Sensitivity analyses, including heterogeneity, pleiotropy tests, leave-one-out, reverse causality were conducted. The IVW model revealed following: (1) relationships triglycerides (TG) (OR: 1.5807, 95% CI: 1.2578–1.9865, P = 0.0001), high-density lipoprotein cholesterol (HDL-C) 0.7342, 0.5729–0.9409, 0.0146), apolipoprotein A1 (ApoA1) 0.6506, 0.5190–0.8156, 0.0002) DN; (2) TG 1.0607, 1.0143–1.1093, 0.0098), HDL-C 0.9453, 0.9053–1.9871, 0.0109), B (ApoB) 1.0672, 0.0070–1.1310, 0.0280) urinary albumin–creatinine ratio (UACR); (3) no relationship total (TC), low-density (LDL-C), ApoB DN, or TC, LDL-C, ApoA1 UACR; (4) none of results showed causality. is risk factor for protective both; protects against UACR. To further underlying mechanisms TG, HDL-C, ApoA1, ApoB, their UACR, provide reference selection management treatment strategies clinical patients. demonstrated that
Language: Английский
Citations
0
BMJ Global Health, Journal Year: 2025, Volume and Issue: 10(4), P. e017187 - e017187
Published: April 1, 2025
Introduction Previous evidence lacked a thorough review of the disparities autoimmune diseases (AD) burdens among countries and regions, which led to an insufficient basis for developing country-specific developmental level relevant preventive measures. This study aimed analyse trends global, regional national burden common ADs in children adolescents from 1990 2019 investigate associations between specific varied country indexes. Methods All data four major were obtained Global Burden Diseases Study 2019. Age period-cohort modelling was conducted disentangle age, period birth cohort effects on AD incidence Local regression smoothing models used fit correlation sociodemographic index (SDI). Pearson’s country-level risk factors disease burden. Results A global increase observed 1.57 million 1.63 0–24 age group. The age-standardised rate overall showed substantial variation with highest high SDI regions. distributions significantly, especially countries. Relative expected associated SDI, distribution by regions depending ADs. Countries higher levels socioeconomic development, better quality life easier access healthcare system lower Conclusions patterns considerably according time generational cohort, across world Incidences significantly correlated indexes involving risks environment, human rights health safety life.
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(16), P. e42124 - e42124
Published: April 18, 2025
This study investigates the causal association between migraine and cardiovascular disease from a genetic perspective based on Mendelian randomization analysis (MR) method. Single nucleotide polymorphism (SNPs) loci were used as instrumental variables (IVs) to analyze potential relationships exposure outcome factors. The in terms of prevalence was assessed using inverse variance weighted primary MR Migraine is negatively associated with coronary artery (CAD) when CAD (OR = 0.0226, 95% CI 0.0019–0.2639, P .0024). 0.9950, 0.9922–0.9978). No other diseases found. demonstrates negative relationship migraine.
Language: Английский
Citations
0