Extranodal Rosai-Dorfman Disease Manifesting as Sjögren’s Syndrome Combined with Panuveitis and Hypertrophic Pachymeningitis: A Case Report and Review of Literature DOI Creative Commons
Jing Xu,

Meihua Huang,

Binsong Dong

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Abstract Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. Case presentation: We present case of 28-year-old female who presented with recurrent blurred vision in her right eye for 3 months. Her left had been blinded atrophied decade prior. She subsequently developed headache, fever, impaired mental status. Cranial MRI indicated hypertrophic pachymeningitis (HP), 18 F-FDG PET/CT revealed significant FDG uptake the dura mater. Autoimmune testing elevated anti-nuclear, anti-SS-A, anti-SS-B antibodies. Incisional biopsy atrophic eyeball RDD marked polyclonal plasmacytosis. The patient was diagnosed accompanied multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, HP. Treatment methylprednisolone over several weeks resulted improvement. Conclusions: This first reported presenting SS combination panuveitis Although rarely young patients, interdisciplinary collaboration essential to prevent delayed diagnosis.

Language: Английский

The Near‐Infrared Light Emitted by LiScO2:Cr3+ Phosphor Used to Induce Gland Secretion for Sjogren's Syndrome DOI Open Access
Lei Chen, Qi Liu, Pingping Li

et al.

Advanced Therapeutics, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract Photobiomodulation is promisingly used as a noninvasive new weapon against Sjogren's syndrome, which disorder of immune system with two main symptoms dry eyes and mouth. This work reports NIR LED device made from LiScO 2 :Cr 3+ phosphor for the application. The absorbance, internal, external quantum efficiency optimal Li(Sc 0.98 Cr 0.02 )O reach 40.9%, 34.5%, 14.1%, respectively; output power energy conversion packaged using driven under 20 mA are 4.23 mW, respectively. emission spectrum can well cover action oxidized Cu A in cytochrome c oxidase molecules. Both pathological changes mice submandibular gland expression human epithelial cells (HSG) AQP5, M3R andEGR1 confirm that light has great potential application treating syndrome. Moreover, study approved therapy more efficient than conventional medicine treatment hydroxychloroquine sulfate.

Language: Английский

Citations

0
Autoantibody against aquaporin-5 may be a new diagnostic biomarker for primary Sjögren’s syndrome DOI Creative Commons

Xiaoyu Wang,

Hong Wu, Bing Zhong

et al.

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(12), P. 3781 - 3787

Published: Oct. 23, 2024

Abstract The study aims to assess the diagnostic and clinical significance of autoantibodies against aquaporin-1 (anti-AQP1) aquaporin-5 (anti-AQP5) in primary Sjögren’s syndrome (pSS). A total 163 participants were categorized into three groups: pSS group, other connective tissue diseases (CTD) healthy control (HC) group. levels anti-AQP1 anti-AQP5 serum determined using enzyme-linked immunosorbent assay (ELISA), data from patients collected for statistical analysis. Our results showed that level group was higher than HC ( P < 0.05), no significant difference observed between CTD > 0.05). ROC had value 39 adults all below cut-off (14.10 ng/ml) AUC 0.86 (95% CI 0.80–0.93), with a sensitivity 0.95 0.87–0.99) specificity 0.70 0.58–0.84). No correlation found EULAR disease activity index score, anti-SSA, anti-SSB, antinuclear antibodies, rheumatoid factor, anti-ds-DNA, salivary gland flow rate, complement 3, lymphocyte count samples respectively. Therefore, elevated may emerge as novel biomarker due high specificity. Key Points •

Language: Английский

Citations

0
Extranodal Rosai–Dorfman disease manifesting as Sjögren’s syndrome combined with panuveitis and hypertrophic pachymeningitis: a case report and review of literature DOI Creative Commons
Jing Xu,

Meihua Huang,

Binsong Dong

et al.

Journal of International Medical Research, Journal Year: 2024, Volume and Issue: 52(4)

Published: April 1, 2024

Rosai–Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. We present the case of 28-year-old woman who presented with recurrent blurred vision in her right eye for 3 months. She developed blindness atrophy left decade prior to presentation. subsequently headache, fever, impaired mental status. Cranial magnetic resonance imaging indicated hypertrophic pachymeningitis (HP), 18 F-fluoro-2-deoxy-2-d-glucose (FDG) positron emission tomography/computed tomography revealed significant FDG uptake dura mater. Autoimmune testing elevated anti-nuclear, anti-SS-A, anti-SS-B antibody levels. Incisional biopsy atrophic eyeball RDD marked polyclonal plasmacytosis. The patient was diagnosed accompanied multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, HP. Treatment methylprednisolone several weeks resulted improvement. This first reported presenting SS combination panuveitis Although rarely young patients, interdisciplinary collaboration essential prevent delayed diagnosis.

Language: Английский

Citations

0
Efficient generation of a stable CHO-K1 cell line overexpressing the human water channel aquaporin-5 as tool to generate therapeutic antibodies DOI Creative Commons
Lucas Jagemann,

Nia Sciucca,

Stefano Bombardieri

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 10, 2024

Aquaporins (AQPs) are a family of water permeable channels expressed on the plasma membrane with AQP5 being major channel in several human tissues including salivary and lacrimal glands. Anti-AQP5 autoantibodies have been observed patients Sjögren's syndrome who characterised by dryness both glands, they implicated underlying mechanisms glandular dysfunction. is formed six transmembrane helices linked three extracellular two intracellular loops. Develop antibodies against protein loops can be challenge due to difficulty maintaining these proteins as recombinant their native form. Therefore, this work we aimed generate an efficient stable-transfected cell line overexpressing (CHO-K1/AQP5) perform primarily cell-based phage display biopanning experiments develop new potential targeting AQP5. We also showed that CHO-K1/AQP5 used study molecular sub-cellular trafficking making cells useful tool for functional studies.

Language: Английский

Citations

0
Extranodal Rosai-Dorfman Disease Manifesting as Sjögren’s Syndrome Combined with Panuveitis and Hypertrophic Pachymeningitis: A Case Report and Review of Literature DOI Creative Commons
Jing Xu,

Meihua Huang,

Binsong Dong

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: May 31, 2023

Abstract Background: Rosai-Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. Case presentation: We present case of 28-year-old female who presented with recurrent blurred vision in her right eye for 3 months. Her left had been blinded atrophied decade prior. She subsequently developed headache, fever, impaired mental status. Cranial MRI indicated hypertrophic pachymeningitis (HP), 18 F-FDG PET/CT revealed significant FDG uptake the dura mater. Autoimmune testing elevated anti-nuclear, anti-SS-A, anti-SS-B antibodies. Incisional biopsy atrophic eyeball RDD marked polyclonal plasmacytosis. The patient was diagnosed accompanied multisystem involvement, including Sjögren’s syndrome (SS), panuveitis, HP. Treatment methylprednisolone over several weeks resulted improvement. Conclusions: This first reported presenting SS combination panuveitis Although rarely young patients, interdisciplinary collaboration essential to prevent delayed diagnosis.

Language: Английский

Citations

0