Lycopene and Garcinia cambogia Induce White-to-Brown Adipose Differentiation: An Innovative Strategy to Curb Obesity DOI Creative Commons
Federica Mannino, Vincenzo Arcoraci, Giovanna Vermiglio

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 986 - 986

Published: July 25, 2024

Obesity is considered one of the main risk factors for cardiovascular diseases. The browning process has been recently recognized as a promising anti-obesity therapy. Lycopene (LYC) and Garcinia cambogia fruit extract (GE) might be important resources drugs; therefore, aim this study was to investigate effects LYC GE on 3T3-L1 adipocytes Zucker rats. Mouse pre-adipocytes were differentiated in mature then treated with (0.5 μM), (30 mg/mL) or + 24 h. Moreover, male Crl:ZUC-Leprfa rats randomly assigned 5 groups 10 animals orally receive Vehicle (Ctrl), Orlistat (20 mg/kg), (5 (1000 mg/kg) 28 days. LYC, GC extracts even more stimulated mRNA protein expression thermogenic genes UCP1, CIDEA DIO2, significantly reduced lipid droplet size increased number adipocytes. UCP1 also visceral adipose tissue that received dietary intake GE. induced reorganization fat depots showed great small significant reduction weight gain food compared control group. obtained results demonstrated used new approaches obesity management order induce achieve metabolically active instead characterized by depot accumulation.

Language: Английский

Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota DOI Open Access
Paola Secchiero, Erika Rimondi, Annalisa Marcuzzi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8098 - 8098

Published: July 25, 2024

In recent years, the incidence of metabolic syndrome (MS) has increased due to lifestyle-related factors in developed countries. MS represents a group conditions that increase risk diabetes, cardiovascular diseases, and other severe health problems. Low-grade chronic inflammation is now considered one key aspects could be defined as new factor. Indeed, an visceral adipose tissue, typical obesity, contributes development inflammatory state, which, turn, induces production several proinflammatory cytokines responsible for insulin resistance. Psoriasis relapsing skin disease characterized by release pro-inflammatory cytokines, which can contribute different pathological within spectrum MS. A link between disorders emerged from evidence indicating weight loss obtained through healthy diets exercise was able improve clinical course therapeutic response patients with obesity or overweight even prevent its occurrence. factor this balance gut microbiota; it extremely dynamic system, makes manipulation diet possible via probiotic, prebiotic, symbiotic compounds. Given this, microbiota additional target metabolism conditions.

Language: Английский

Citations

4
Excessive or sustained endoplasmic reticulum stress: one of the culprits of adipocyte dysfunction in obesity DOI Creative Commons

Yu Jiang,

Jiaqi Guo,

Ya Wu

et al.

Therapeutic Advances in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 1, 2024

As the prevalence of obesity continues to rise globally, research on adipocytes has attracted more and attention. In presence nutrient overload, are exposed pressures such as hypoxia, inflammation, mechanical stress, metabolite, oxidative stress that can lead organelle dysfunction. Endoplasmic reticulum (ER) is a vital for sensing cellular pressure, its homeostasis essential maintaining adipocyte function. Under conditions excess nutrition, ER (ERS) will be triggered by gathering abnormally folded proteins in lumen, resulting activation signaling response known unfolded protein responses (UPRs), which system relieve ERS restore homeostasis. However, if UPRs fail rescue homeostasis, activate pathways damage cells. Studies have shown role disturbed pathophysiology complications. Prolonged or excessive aggravate lipolysis, insulin resistance, apoptosis affect bioactive molecule production. addition, also impacts expression some important genes. view fact influences function through various mechanisms, targeting may viable strategy treat obesity. This article summarizes effects during

Language: Английский

Citations

2
Analyzing Obesity Trends in American Children and Adolescents: Comprehensive Examination Using the National Center for Health Statistics (NCHS) Database DOI Open Access
Oluwatosin B Iyun, Okelue E Okobi,

Elochukwu U Nwachukwu

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 6, 2024

Background In the USA, obesity in children and adolescents has become a major public health concern. Childhood been linked to various cardiometabolic comorbidities all through one's life. Owing significant increment childhood rates, there an urgent need for identification of correlates antecedents adiposity risk enable early prevention obesity. As such, objective this study is analyze trends American from 1999 2018 using National Center Health Statistics (NCHS) database, as will factors Objective This aimed comprehensively examine demographic impacting prevalence, including gender, age groups (two five, six 11, 12-19 years), race/ethnicity, poverty level. Methods The conducted retrospective analysis NCHS database 2018. Utilizing data, we examined evolution prevalence among adolescents. focused on variations, age, percentage SPSS version 24, statistical software by IBM Corp. (Chicago, IL, USA), was used summarization, graphical representation, presenting across participants. Results Temporal exhibited notable fluctuations revealed disparities groups, genders, race/ethnicities, socioeconomic status categories. Gender-based variations persist, with boys consistently surpassing girls (17.5% vs. 16%, p = 0.0231). Varied group patterns emerged, peaking at 18.7% years, 17.7% 11 11.2% two five years. Racially, Hispanic individuals had highest (22.8%), followed Mexican (22.0%) Black or African American-only (20.6%). White-only showed 14.4%, Asian-only lowest (9.4%). Lower brackets correlate higher instances, particularly below 100% level (20%). 100-199%, 200-399%, 400% more categories contributed 18.6%, 16.6%, 11.6%, respectively. Conclusion Our extensive examination 2018, utilizing provides valuable insights into complex interplay influencing reveals age-specific emphasizing unique challenges during adolescence. Gender disparities, influences, racial/ethnic impacts are evident, underscoring further study. findings present several policy implications regarding development interventions reducing rates USA. For instance, indicate policymakers develop enabling infancy stages. highlight observed between genders races/ethnic groups. Developing executing prone considerably reduce

Language: Английский

Citations

1
Lycopene and Garcinia cambogia Induce White-to-Brown Adipose Differentiation: An Innovative Strategy to Curb Obesity DOI Creative Commons
Federica Mannino, Vincenzo Arcoraci, Giovanna Vermiglio

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 986 - 986

Published: July 25, 2024

Obesity is considered one of the main risk factors for cardiovascular diseases. The browning process has been recently recognized as a promising anti-obesity therapy. Lycopene (LYC) and Garcinia cambogia fruit extract (GE) might be important resources drugs; therefore, aim this study was to investigate effects LYC GE on 3T3-L1 adipocytes Zucker rats. Mouse pre-adipocytes were differentiated in mature then treated with (0.5 μM), (30 mg/mL) or + 24 h. Moreover, male Crl:ZUC-Leprfa rats randomly assigned 5 groups 10 animals orally receive Vehicle (Ctrl), Orlistat (20 mg/kg), (5 (1000 mg/kg) 28 days. LYC, GC extracts even more stimulated mRNA protein expression thermogenic genes UCP1, CIDEA DIO2, significantly reduced lipid droplet size increased number adipocytes. UCP1 also visceral adipose tissue that received dietary intake GE. induced reorganization fat depots showed great small significant reduction weight gain food compared control group. obtained results demonstrated used new approaches obesity management order induce achieve metabolically active instead characterized by depot accumulation.

Language: Английский

Citations

1