Ways to think about vasculitic neuropathy DOI
Mahima Kapoor, Stephen Reddel

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(5), P. 478 - 486

Published: July 24, 2024

Purpose of review Vasculitis as a pathomechanism for neuropathy can be isolated to the peripheral nervous system, part systemic autoimmune condition or component another syndrome. This aims discuss broad range diagnoses in which vasculitic encountered, highlight progress imaging techniques identifying vasculitis, and new drugs developed other diseases that may applied neurological conditions. Recent findings Advances modalities, ultrasound, MRI FDG-PET scanning neuromuscular applications has redefined many aspects neuropathies. The benefit dividing vasculitides by vessel size is becoming less absolute diagnostic approaches advance. are widely used diagnosis, defining extent involvement disease monitoring. In neuralgic amyotrophy, identification hourglass-like constrictions on changed treatment paradigm include surgical interventions. These supported immunomodulating immunosuppression techniques. Summary Vasculitic neuropathies group conditions with causes associations. Increased use impacts our traditional definitions classifications. growth options likely infiltrate landscape.

Language: Английский

Comparison of [18F]FAPI-42 and [18F]FDG PET/CT in the evaluation of systemic vasculitis DOI

Kaixiang Zhong,

Haiming Chen, Peng Hou

et al.

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Citations

3
Ca2+ Signaling in Cardiovascular Fibroblasts DOI Creative Commons
Andreas Rinne, Florentina Pluteanu

Biomolecules, Journal Year: 2024, Volume and Issue: 14(11), P. 1365 - 1365

Published: Oct. 27, 2024

Fibrogenesis is a physiological process required for wound healing and tissue repair. It induced by activation of quiescent fibroblasts, which first proliferate then change their phenotype into migratory, contractile myofibroblasts. Myofibroblasts secrete extracellular matrix proteins, such as collagen, to form scar. Once the terminated, most myofibroblasts undergo apoptosis. However, in some tissues, heart, remain active sensitive neurohumoral factors inflammatory mediators, lead eventually excessive organ fibrosis. Many cellular processes involved fibroblast activation, including cell proliferation, protein secretion contraction, are highly regulated intracellular Ca

Language: Английский

Citations

2
Targeting interleukin-6 pathways in giant cell arteritis management: A narrative review of evidence DOI Creative Commons
Maxime Samson, Bhaskar Dasgupta, Anthony M. Sammel

et al.

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 24(2), P. 103716 - 103716

Published: Dec. 5, 2024

Giant cell arteritis (GCA) is a chronic inflammatory vasculitis with significant impact on vascular and patient health. It may present non-specific symptoms can lead to severe complications if not managed effectively. This narrative review explores the treatment of GCA interleukin-6 (IL-6) pathway inhibitors, focusing key studies from selected databases published between 2018 2024. The findings reveal that current primarily involves glucocorticoids (GCs), but their long-term use associated adverse effects. Targeting IL-6 offers therapeutic benefits by reducing inflammation sparing GC use. Tocilizumab, humanized immunoglobulin G1κ monoclonal antibody blocks receptor, has demonstrated efficacy in achieving sustained remission improving quality life people GCA. However, challenges remain understanding optimal duration therapy, managing relapse upon discontinuation, addressing structural outcomes. Additional research needed further elucidate complex pathogenesis optimize strategies achieve both clinically histologically while minimizing provides comprehensive overview evidence inhibition management, highlighting its

Language: Английский

Citations

1
Ways to think about vasculitic neuropathy DOI
Mahima Kapoor, Stephen Reddel

Current Opinion in Neurology, Journal Year: 2024, Volume and Issue: 37(5), P. 478 - 486

Published: July 24, 2024

Purpose of review Vasculitis as a pathomechanism for neuropathy can be isolated to the peripheral nervous system, part systemic autoimmune condition or component another syndrome. This aims discuss broad range diagnoses in which vasculitic encountered, highlight progress imaging techniques identifying vasculitis, and new drugs developed other diseases that may applied neurological conditions. Recent findings Advances modalities, ultrasound, MRI FDG-PET scanning neuromuscular applications has redefined many aspects neuropathies. The benefit dividing vasculitides by vessel size is becoming less absolute diagnostic approaches advance. are widely used diagnosis, defining extent involvement disease monitoring. In neuralgic amyotrophy, identification hourglass-like constrictions on changed treatment paradigm include surgical interventions. These supported immunomodulating immunosuppression techniques. Summary Vasculitic neuropathies group conditions with causes associations. Increased use impacts our traditional definitions classifications. growth options likely infiltrate landscape.

Language: Английский

Citations

0