Ginsenosides Modulate Immunity via TLR4/MyD88/NF-κB Pathway and Gut Microbiota

Phytomedicine, Journal Year: 2025, Volume and Issue: 142, P. 156763 - 156763

Published: April 12, 2025

Language: Английский

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Development and validation of a prognostic nomogram for predicting mortality risk in adult rheumatoid arthritis: an analysis of NHANES 1999–2018 data

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

This study aims to identify potential independent risk factors for rheumatoid arthritis (RA)- related mortality and develop a nomogram model predict individualized risk. included 310 RA patients from the National Health Nutrition Examination Survey (NHANES) during 1999 - 2018. We applied LASSO, univariate, multivariate logistic regression analyses determine in training cohort construct model. Calibration plots evaluated nomogram's accuracy. Finally, we established clinical utility through DCA performed internal validation within cohort. Of patients, 140 experienced deaths, corresponding rate of 45.16%. Within cohort, age, heart failure, systemic inflammatory response index (SIRI) emerged as predictors mortality. A model, constructed multivariable analysis, demonstrated an AUC 0. 852 (95% CI: 799 904) 904 846 963) The calibration curve revealed strong agreement between predicted actual probabilities. In both cohorts, highlighted significant net benefits predicting demonstrates SIRI's ability with good discrimination utility. gives clinicians simple tool quickly high promoting early intervention, personalized treatment, better prognosis.

Language: Английский

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Autophagy in myositis, a dysregulated pathway, and a target for therapy

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103817 - 103817

Published: April 1, 2025

Language: Английский

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Immune cell contribution to vascular complications in diabetes

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 21, 2025

Diabetes mellitus often results in vascular complications, significantly impacting patients’ well-being. This review focuses on the role of immune cells these examining their mechanisms, biomarkers, and treatment strategies. Immune cells, including macrophages, T B contribute to development both macrovascular microvascular complications by secreting inflammatory factors modulating responses. For instance, diabetic coronary artery disease, macrophages form foam promote inflammation, whereas nephropathy, an imbalance T-cell subsets exacerbates condition. Novel immune-related such as soluble cytokine receptors specific microRNAs, offer new avenues for early diagnosis monitoring. Current treatments focus inflammation oxidative stress, while emerging therapies, stem cell precision medicine, show promise but also present challenges. systematically summarizes analyzes pertinent research. Its significance lies synthesizing current research findings, identifying knowledge gaps, providing guidance future basic clinical practice. By elucidating critical it aids therapeutic targets more effective Moreover, exploration novel biomarkers opens up possibility disease intervention, landscape challenges encourages clinicians make rational decisions. Overall, aim is enhance prognoses, alleviate medical burden, advance progress diabetes treatment.

Language: Английский

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The Impact of Triglycerides on Rheumatoid Arthritis: Risk Factor and Mendelian Randomization Study

Open Access Rheumatology Research and Reviews, Journal Year: 2025, Volume and Issue: Volume 17, P. 101 - 115

Published: May 1, 2025

Language: Английский

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