Circadian phase inversion causes insulin resistance in a rat model of night work and jet lag

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 20, 2025

Shift workers have an increased risk to develop type 2 diabetes. We aimed investigate the underlying mechanisms and role of timing food intake by subjecting rats acute phase inversion light/dark (L/D) cycle. In first experiment, with available ad libitum, male Wistar were implanted jugular vein catheters intravenous glucose tolerance tests performed at either ZT2 or ZT14. Three days after 12 h shift, these repeated. second housed in metabolic cages for continuous measurement multiple behavioral parameters was libitum restricted light dark period. The daily rhythm tolerance, peak trough corticosterone levels, adapted within three exposure inverted L/D However, caused insulin resistance onset active phase. Under feeding conditions, rhythms locomotor activity energy expenditure faster cycle compared other measured. Food restriction period facilitated adaptation new circadian

Language: Английский

Zebra finches (Taeniopygia castanotis) display varying degrees of stress resilience and recovery in response to constant light

General and Comparative Endocrinology, Journal Year: 2024, Volume and Issue: unknown, P. 114644 - 114644

Published: Nov. 1, 2024

Language: Английский