Interferon and immunity: the role of microRNA in viral evasion strategies DOI Creative Commons
Mobina Bayat,

Rahil Nahid-Samiei,

Javid Sadri Nahand

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Interferons (IFNs) are indispensable innate antiviral cytokines that orchestrate the vertebrate immune response against viral incursions. Nearly every cell possesses remarkable ability to release IFNs upon detecting threats, triggering a robust signaling cascade alerts neighboring cells and halts propagation via paracrine communication. The intricate influence of is mediated by an extensive network proteins activated through Jak-STAT pathways, facilitating swift transcription over 300 interferon-stimulated genes (ISGs) fortify cellular defenses replication. However, cunning nature viruses has led evolution sophisticated evasion strategies, notably manipulation host microRNAs (miRNAs) disrupt vital components IFN machinery. This review delves into interplay between infections both host- viral-derived miRNAs, exploring their potent roles in modulating RIG-I-like receptors, Toll-like JAK/STAT pathway, ultimately shaping landscape immunity.

Language: Английский

Integrative computational analysis of HCMV-encoded miRNAs: Mapping host protein interactions and immune evasion mechanisms DOI
Aroni Chatterjee, Saurav Dey,

Hiya Ghosh

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102255 - 102255

Published: May 1, 2025

Language: Английский

Citations

0
Interferon and immunity: the role of microRNA in viral evasion strategies DOI Creative Commons
Mobina Bayat,

Rahil Nahid-Samiei,

Javid Sadri Nahand

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Interferons (IFNs) are indispensable innate antiviral cytokines that orchestrate the vertebrate immune response against viral incursions. Nearly every cell possesses remarkable ability to release IFNs upon detecting threats, triggering a robust signaling cascade alerts neighboring cells and halts propagation via paracrine communication. The intricate influence of is mediated by an extensive network proteins activated through Jak-STAT pathways, facilitating swift transcription over 300 interferon-stimulated genes (ISGs) fortify cellular defenses replication. However, cunning nature viruses has led evolution sophisticated evasion strategies, notably manipulation host microRNAs (miRNAs) disrupt vital components IFN machinery. This review delves into interplay between infections both host- viral-derived miRNAs, exploring their potent roles in modulating RIG-I-like receptors, Toll-like JAK/STAT pathway, ultimately shaping landscape immunity.

Language: Английский

Citations

0