British Journal of Haematology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 7, 2024
There
has
been
an
expansion
in
our
understanding
of
the
multifaceted
roles
circulating
blood
cells
regulating
haemostasis
and
contributing
to
thrombosis.
Notably,
there
is
greater
recognition
interplay
between
coagulation
with
inflammation
innate
immune
activation
contribution
leucocytes.
The
full
count
(FBC)
a
time-honoured
test
medicine;
however,
its
components
are
often
viewed
isolation
without
consideration
their
haemostatic
thrombotic
potential.
Here,
we
review
how
individual
FBC,
that
is,
haemoglobin,
platelets
leucocytes,
engage
system
focus
on
both
quantitative
qualitative
attributes.
We
also
explore
this
information
can
be
harnessed
into
better
management
people
multiple
long-term
conditions
because
higher
risk
adverse
clinical
events.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
Sepsis-induced
cardiomyopathy
is
a
reversible
non-ischemic
acute
cardiac
dysfunction
associated
with
sepsis.
It
strongly
an
abnormal
immune
response.
emerges
as
vital
threat
to
public
health
owing
its
high
mortality
rate.
However,
the
exact
pathogenesis
requires
further
investigation.
In
recent
years,
NETosis
and
ferroptosis,
which
are
novel
modes
of
programmed
cell
death,
have
been
identified
found
play
important
roles
in
sepsis-related
organ
damage.
This
article
outlines
mechanisms
these
two
discusses
role
neutrophil
extracellular
traps
myocardial
injury
importance
ferroptosis
sepsis-induced
cardiomyopathy,
reviews
potential
interconnection
between
types
death
cardiomyopathy.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 14, 2025
Lung
diseases,
including
acute
lung
injury
(ALI)
and
respiratory
distress
syndrome
(ARDS),
are
associated
with
various
etiological
factors
characterized
by
high
mortality
rates.
Current
treatment
strategies
primarily
focus
on
lung-protective
ventilation
careful
fluid
management.
Despite
over
50
years
of
basic
clinical
research,
effective
options
remain
limited,
the
search
for
novel
continues.
Traditionally,
platelets
have
been
viewed
as
contributors
to
blood
coagulation;
however,
recent
research
has
revealed
their
significant
role
in
inflammation
immune
regulation.
While
relationship
between
platelet
count
ALI/ARDS
remained
unclear,
emerging
studies
highlight
“dual
role”
these
conditions.
On
one
hand,
interact
neutrophils
form
neutrophil
extracellular
traps
(NETs),
promoting
thrombosis
exacerbating
inflammation.
other
also
play
a
protective
modulating
inflammation,
regulatory
T
cell
(Treg)
activity,
assisting
alveolar
macrophage
reprogramming.
This
dual
functionality
important
implications
pathogenesis
resolution
ALI/ARDS.
review
examines
multifaceted
roles
ALI/ARDS,
focusing
immunomodulatory
effects,
platelet-neutrophil
interaction,
critical
involvement
platelet-Treg
complexes
shaping
inflammatory
environment
ALI.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1219 - 1219
Published: Sept. 17, 2024
Arterial
thrombosis,
a
condition
in
which
thrombi
form
arteries,
can
lead
to
various
acute
cardiovascular
diseases
and
impact
the
quality
of
life
survival
patients.
Berberine
(BBR),
quaternary
ammonium
alkaloid,
has
been
shown
treat
these
diseases.
However,
further
exploration
is
needed
understand
underlying
mechanisms
BBR.
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Dec. 31, 2024
Platelets
are
essential
for
blood
clotting
and
maintaining
normal
hemostasis.
In
pathological
conditions,
platelets
increasingly
recognized
as
crucial
regulatory
factors
in
various
immune-mediated
inflammatory
diseases.
Resting
induced
by
such
immune
complexes
through
Fc
receptors,
platelet-targeting
autoantibodies
other
platelet-activating
stimuli.
Platelet
activation
immunological
processes
involves
the
release
of
stimuli,
antigen
presentation
interaction
with
cells.
participate
both
innate
system
(neutrophils,
monocytes/macrophages,
dendritic
cells
(DCs)
Natural
Killer
(NK)
adaptive
(T
B
cells).
Clinical
therapeutic
strategies
include
targeting
platelet
activation,
platelet-immune
cell
platelet-endothelial
interaction,
which
display
positive
development
prospects.
Understanding
mechanisms
immunity
is
important,
developing
targeted
modulations
these
will
pave
way
promising
strategies.
Almanac of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
51(8), P. 469 - 477
Published: Feb. 11, 2024
The
review
summarizes
current
understanding
of
neutrophil
extracellular
traps
(NETs)
and
their
role
in
the
development
inflammation
thrombus
formation
during
physiological
complicated
pregnancy.
main
initiation
factors
molecular
cellular
reactions
leading
to
generation
NETs
are
described.
During
gestation,
various
pregnancy-associated
triggers
(cytokines,
hormones,
colony-stimulating
factors,
etc.)
contribute
increased
activity
innate
immune
associated
with
processes
migration
into
gestational
tissues,
adhesion,
degranulation,
phagocytosis
release
traps.
It
has
been
established
that
uncontrolled
aberrant
NETs,
as
well
products,
including
reactive
oxygen
species,
can
exert
a
cytotoxic
effect
on
maternal
cells
adverse
fetal
effects
placental
damage,
resulting
such
pregnancy
complications
disorders,
immunothrombosis
preeclampsia.
emergence
new
data
morphological
functional
characteristics
component
immunity
necessitates
advanced
research
consideration
potential
conditions
for
formation,
clarification
determination
pathophysiological
significance
normal
seems
promising
study
possibility
assessment
DNA
levels
early
diagnosis
prognosis
complications,
treatment
strategies
targeted
therapy.
British Journal of Haematology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 7, 2024
There
has
been
an
expansion
in
our
understanding
of
the
multifaceted
roles
circulating
blood
cells
regulating
haemostasis
and
contributing
to
thrombosis.
Notably,
there
is
greater
recognition
interplay
between
coagulation
with
inflammation
innate
immune
activation
contribution
leucocytes.
The
full
count
(FBC)
a
time-honoured
test
medicine;
however,
its
components
are
often
viewed
isolation
without
consideration
their
haemostatic
thrombotic
potential.
Here,
we
review
how
individual
FBC,
that
is,
haemoglobin,
platelets
leucocytes,
engage
system
focus
on
both
quantitative
qualitative
attributes.
We
also
explore
this
information
can
be
harnessed
into
better
management
people
multiple
long-term
conditions
because
higher
risk
adverse
clinical
events.
