Metabolic reprogramming in tumor immune microenvironment: Impact on immune cell function and therapeutic implications

Cancer Letters, Journal Year: 2024, Volume and Issue: 597, P. 217076 - 217076

Published: June 19, 2024

Understanding of the metabolic reprogramming has revolutionized our insights into tumor progression and potential treatment. This review concentrates on aberrant pathways in cancer cells within microenvironment (TME). Cancer differ from normal their processing glucose, amino acids, lipids order to adapt heightened biosynthetic energy needs. These shifts, which crucially alter lactic acid, acid lipid metabolism, affect not only cell proliferation but also TME dynamics. explores various immune TME. From a therapeutic standpoint, targeting these alterations represents novel treatment strategy. discusses approaches regulation metabolism different nutrients influencing enhance response. In summary, this summarizes its as target for innovative strategies, offering fresh perspectives

Language: Английский

---

The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 99, P. 24 - 44

Published: Feb. 1, 2024

Autophagy, a self-degradative process vital for cellular homeostasis, plays significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, cancer development, with specific emphasis on how obesity-driven changes affect regulation of autophagy subsequent implications risk. The burgeoning epidemic obesity underscores relevance this research, particularly given established links various cancers. Our exploration delves into hormonal influence, notably INS (insulin) LEP (leptin), interactions. Further, we draw attention latest findings molecular factors linking cancer, including changes, altered metabolism, secretory autophagy. We posit that targeting modulation may offer potent therapeutic approach obesity-associated pointing promising advancements nanocarrier-based targeted therapies modulation. However, also recognize challenges inherent these approaches, concerning their precision, control, dual roles can play cancer. Future research directions include identifying novel biomarkers, refining therapies, harmonizing approaches precision medicine principles, thereby contributing more personalized, effective treatment paradigm obesity-mediated

Language: Английский

---

Bitter Taste Receptor T2R14 and Autophagy Flux in Gingival Epithelial Cells

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 531 - 531

Published: March 17, 2024

Macroautophagy (hereafter autophagy) is a lysosomal degradation pathway that functions in nutrient recycling and as mechanism of innate immunity. Previously, we reported novel host–bacteria interaction between cariogenic S. mutans bitter taste receptor (T2R14) gingival epithelial cells (GECs), leading to an immune response. Further, might be using the host system inhibit other Gram-positive bacteria, such aureus. To determine whether these bacteria exploit autophagic machinery GEC, it first necessary evaluate role T2R14 modulating flux. So far, regulation autophagy not well characterized. Therefore, this study, for time, report downregulates flux GECs, knockout increases acidic vacuoles. However, treatments GEC WT with agonist antagonist did lead significant change vacuole formation. Transmission electron microscopy morphometric results also suggested increased number vesicles T2R14-knockout GEC. our suggest competence stimulating peptide CSP-1 showed robust intracellular calcium release effect both T2R14- protein 7-dependent. In provide evidence modulates The current study could help identifying impact T2R immuno-microenvironment subsequently oral health.

Language: Английский

---

Therapeutic and diagnostic applications of exosomes in colorectal cancer

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(8)

Published: July 20, 2024

Language: Английский

---

Evaluation of Mitochondrial Phagy (Mitophagy) in Human Non-small Adenocarcinoma Tumor Cells

Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

---

Sustainable nanomaterials for precision medicine in cancer therapy

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: 27, P. 100865 - 100865

Published: May 27, 2024

Language: Английский

---

The involvement of circRNAs in molecular processes and their potential use in therapy and diagnostics for glioblastoma

Gene, Journal Year: 2025, Volume and Issue: 940, P. 149214 - 149214

Published: Jan. 5, 2025

Language: Английский

---

Mechanistic insights and therapeutic strategies for targeting autophagy in pancreatic ductal adenocarcinoma

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 23, 2025

Language: Английский

---

Breaking Barriers in Oncology: Harnessing Sonodynamic Therapy for Enhanced Tumor Metabolism Regulation

Small, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Abstract The recent booming development of sonometabolism regulation in controlling the tumor microenvironment (TME) has opened a new research area to identify innovative approaches against cancer. aim this review is highlight potentials and advantages sonodynamic therapy (SDT) antitumor nanotherapies, specifically, delineating progress made SDT concerning TME metabolism which encompasses factors such as hypoxia, redox balance, autophagy, immunosuppression, ion homeostasis, other metabolic processes. By focusing on both cell dynamics, wide range strategies that have demonstrated great therapeutic effectiveness by targeting functions inherent are summarized. In conclusion, offers valuable insights for researchers involved SDT‐based strategies, with advancing methodologies future research.

Language: Английский

---

Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions

Biomolecules, Journal Year: 2024, Volume and Issue: 14(6), P. 649 - 649

Published: May 31, 2024

The p53 protein is the master regulator of cellular integrity, primarily due to its tumor-suppressing functions. Approximately half all human cancers carry mutations in TP53 gene, which not only abrogate tumor-suppressive functions but also confer mutant proteins with oncogenic potential. latter achieved through so-called gain-of-function (GOF) that promote cancer progression, metastasis, and therapy resistance by deregulating transcriptional networks, signaling pathways, metabolism, immune surveillance, compositions microenvironment. Despite recent progress understanding complexity mutp53 neoplastic development, exact mechanisms how contributes development they escape proteasomal lysosomal degradation remain partially understood. In this review, we address findings field specifically regarding, limited to, implications metabolic secretome cells, microenvironment, regulating scenarios aberrant degradation. By analyzing degradation, as well connection autophagy, propose new therapeutical approaches aim destabilize deactivate functions, thereby providing a fundamental basis for further investigation rational treatment TP53-mutated cancers.

Language: Английский

---