Editorial on the Special Issue Titled “Pathology and Diagnosis of Gynecologic Diseases” DOI Creative Commons
Cinzia Giacometti, Kathrin Ludwig

Diagnostics, Journal Year: 2023, Volume and Issue: 13(22), P. 3480 - 3480

Published: Nov. 20, 2023

In the medical and diagnostic daily routine, gynecologic diseases present many different scenarios [...].

Language: Английский

Amelioration of endothelial integrity by 3,5,4′-trihydroxy-trans-stilbene against high-fat-diet-induced obesity and -associated vasculopathy and myocardial infarction in rats, targeting TLR4/MyD88/NF-κB/iNOS signaling cascade DOI
Jitender Singh, Priyanka Bisht,

Srishti Srivastav

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 705, P. 149756 - 149756

Published: March 5, 2024

Language: Английский

Citations

6

Placental mitochondrial impairment and its association with maternal metabolic dysfunction DOI

Adriana Grismaldo R,

Luis Alberto Luévano‐Martínez,

M Loreto Reyes

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 8, 2024

Abstract The placenta plays an essential role in pregnancy, leading to proper fetal development and growth. As organ with multiple physiological functions for both mother fetus, it is a highly energetic metabolically demanding tissue. Mitochondrial physiology crucial the metabolism of this thus any alteration mitochondrial dysfunction has severe outcome fetus. Pregnancy‐related pathological states include preeclampsia gestational diabetes mellitus. In review, we address morphology, during highlighting roles cytotrophoblast syncytiotrophoblast. We also describe relationship between preeclampsia, diabetes, diabesity pre‐pregnancy maternal obesity dysfunction. image

Language: Английский

Citations

4

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases DOI Open Access
Mariana S. Diniz, Carina C. Magalhães, Carolina Tocantins

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4623 - 4623

Published: Oct. 31, 2023

Chronic diseases represent one of the major causes death worldwide. It has been suggested that pregnancy-related conditions, such as gestational diabetes mellitus (GDM), maternal obesity (MO), and intra-uterine growth restriction (IUGR) induce an adverse intrauterine environment, increasing offspring’s predisposition to chronic later in life. Research mitochondrial function oxidative stress may play a role developmental programming diseases. Having this mind, review, we include evidence dysfunction are mechanisms by which GDM, MO, IUGR program offspring In specific context, explore promising advantages antioxidant supplementation using compounds resveratrol, curcumin, N-acetylcysteine (NAC), Mitoquinone (MitoQ) addressing metabolic associated with fetoplacental health. This approach holds potential mitigate programming-related risk diseases, serving probable intervention for disease prevention.

Language: Английский

Citations

10

Exploring Endothelial Cell Dysfunction’s Impact on the Brain-Retina Microenvironment Connection: Molecular Mechanisms and Implications DOI
Wahid Shah, Yuanyuan Gong, Xinhan Qiao

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

0

Prediction of Gestational Diabetes Mellitus (GDM) risk in early pregnancy based on clinical data and ultrasound information: a nomogram DOI Creative Commons
Tong Zhu, Lin Tang, Man Qin

et al.

BMC Medical Informatics and Decision Making, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 18, 2025

Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy and has been on a continuous increase in recent years. This study aimed to establish combined prediction model for risk GDM provide more reliable reference information non-invasive assessment clinical practice. retrospectively collected data ultrasound 122 pregnant women who underwent fetal nuchal translucency screening, which divided into 36 cases group 86 non-gestational mellitus(NGDM) group. The were analyzed using Student's t-test Wilcoxon W test univariate analysis. Independent factors patients with screened through binary logistic regression A was established based results, diagnostic performance different models evaluated by drawing receiver operating characteristic curve(ROC). optimal selected, calibration curve decision drawn evaluate goodness fit application efficiency model. Univariate results showed that age, body mass index(BMI), number abortions, gravidity, placental volume(PV), vascularization index(VI), flow index(FI), index(VFI) all had statistically significant differences between NGDM groups(p < 0.05). Binary analysis BMI, PV, VI, FI independent development (p Based these five this study. Their area under ROC curve(AUC) 0.67, 0.80, 0.87, 0.85, respectively. combining 30° highest AUC, so we constructed nomogram its good fit, efficiency. accuracy value predicting GDM.

Language: Английский

Citations

0

Uteroplacental microvascular remodeling in health and disease DOI Open Access
Ruizhi Li,

Lei Ma,

Yan Geng

et al.

Acta Physiologica, Journal Year: 2025, Volume and Issue: 241(5)

Published: March 29, 2025

The microvascular system is essential for delivering oxygen and nutrients to tissues while removing metabolic waste. During pregnancy, the uteroplacental undergoes extensive remodeling meet increased demands of fetus. Key adaptations include vessel dilation increases in vascular volume, density, permeability, all which ensure adequate placental perfusion maintaining stable maternal blood pressure. Structural functional abnormalities microvasculature are associated with various gestational complications, posing both immediate long-term risks health mother infant. In this review, we describe changes microvessels during discuss pathogenic mechanisms underlying diseases such as preeclampsia, fetal growth restriction, diabetes, summarize current clinical research approaches monitoring health. We also provide an update on models complications explore solutions several unresolved challenges. With advancements techniques, anticipate significant progress understanding managing these diseases, ultimately leading new therapeutic strategies improve

Language: Английский

Citations

0

Endothelial‐to‐mesenchymal transition in the fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational diabetes DOI Creative Commons
Abigail Byford, Georgia Fakonti,

Ziyu Shao

et al.

The Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 11, 2025

Abstract Gestational diabetes mellitus (GDM) is linked to altered fetal development and an increased risk of offspring developing cardiometabolic diseases in adulthood. The mechanisms responsible are unclear; however, GDM associated with fetoplacental vascularisation, fibrosis endothelial dysfunction. In non‐pregnant individuals diabetes, similar vascular changes attributed disruptions endothelial‐to‐mesenchymal transition (EndMT), a key process where cells adopt mesenchymal phenotype. Here, we assess whether alterations the macro‐ microvasculature EndMT, using human umbilical vein (HUVECs) term placental tissue, respectively. Transforming growth factor (TGF)‐β2 interleukin (IL)‐1β induced morphological molecular consistent EndMT both non‐GDM HUVECs. ability TGF‐β2 IL‐1β alter expression known regulators, VWF , TGFBR1 IL1B IL1R1 was diminished HUVECs; all other hallmarks were similar. villous Slug Snail, two transcriptional regulators detected stroma, suggesting that probably occurs microvasculature. We observed reduction marker genes PECAM1 CDH5 placentas, reduced vascularisation. This accompanied by SNAI2 TGB2 TGFB3 TGFBR2 ; there no change markers or regulators. suggests may be some but this does not fully explain dysfunction vascularisation vasculature pregnancies complicated GDM. image Key points has been Disruptions phenotype, complications investigated. (HUVECs). Although mediators, HUVECs, Transcriptional placenta. Despite markers, as well TGFB2/3 placenta, markers. that, although GDM, explained EndMT.

Language: Английский

Citations

0

Does Insulin treatment affect Umbilical Artery Doppler indices in pregnancies complicated by gestational diabetes? DOI Creative Commons
Libera Troìa, Stefania Ferrari,

Anna Dotta

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Purpose Gestational diabetes mellitus (GDM) is one of the most common morbidities pregnancy. The impact increased maternal blood glucose on fetoplacental hemodynamics not fully elucidated, especially in patients with uncontrolled GDM necessitating insulin therapy. objective this study was to assess therapy umbilical artery dopplers pregnancies adequate for gestational age fetuses. Methods Retrospective observational among 447 pregnant women, divided according their treatment: nutritiona (NT), long acting (LA) and combined insulin. pulsatility index (UA-PI) recorded at 28, 32 36 weeks. Results UA-PI values declined both healthy controls all 3 time interval. group showed always a reduced comparison LA but difference never reached statistical significance. exhibited significant 36-weeks’ gestation compared NT groups. Conclusion A decreased impedence flow diabetic mothers observed, more pronounced during final stage Maternal hyperglycemia could have worsening effect fetal vasculature. Nevertheless, extent which PI can predict unfavorable outcomes associated has yet be determined. Further additional prospective studies are necessary confirm precise levels medical interventions circulation fetus mother.

Language: Английский

Citations

1

Does Insulin Treatment Affect Umbilical Artery Doppler Indices in Pregnancies Complicated by Gestational Diabetes? DOI Open Access
Libera Troìa, Stefania Ferrari,

Anna Dotta

et al.

Healthcare, Journal Year: 2024, Volume and Issue: 12(19), P. 1972 - 1972

Published: Oct. 3, 2024

Background/Objectives: Gestational diabetes mellitus (GDM) is one of the most common morbidities pregnancy. The impact increased maternal blood glucose on fetoplacental hemodynamics not fully elucidated, especially in patients with uncontrolled GDM necessitating insulin therapy. objective this study was to assess therapy umbilical artery dopplers pregnancies adequate for gestational-age fetuses. Methods: Retrospective observational among 447 pregnant women, divided according their treatment (nutritional (NT), long acting (LA) insulin, combined insulin) and 100 healthy controls same gestational age. pulsatility index (UA-PI) recorded at 28, 32 36 weeks. Results: UA-PI values declined both all three time intervals. group showed reduced comparison LA group, but difference never reached statistical significance. exhibited significantly 32- 36-weeks’ gestation compared NT groups. Conclusions: A decreased impedance flow diabetic mothers observed. This more pronounced during last trimester. extent which PI can predict unfavorable outcomes has yet be determined. Further additional studies are necessary confirm precise levels medical interventions circulation fetus mother.

Language: Английский

Citations

1

Shortcomings, limitations and gaps in physiological roles of extracellular vesicles in obesity DOI Open Access
Paola Valero, Katherin Silva, Andrés Valenzuela‐Hinrichsen

et al.

The Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Extracellular vesicles (EVs) play a crucial role in mediating communication between cells across species and kingdoms. The intercellular facilitated by EVs through autocrine paracrine signalling mechanisms is essential for cell survival, maintaining normal metabolic functions ensuring overall bodily homeostasis health. are present various fluids, such as pleural effusions, plasma, breast milk, amniotic fluid, semen saliva. Additionally, the generation release of contribute to removal cellular waste. Patients with obesity exhibit higher amount circulating than individuals weight. This increased EV might inflammatory state characteristic this condition, because levels pro‐inflammatory molecules found within their cargo. However, interpreting results related abundance, cargo biological actions can be complicated several factors; these include variations sources, wide age range (from children elderly), mix females males, medication use health status, body weights weight morbid obesity) differences vitro assays using lines versus primary cultures. article addresses shortcomings, limitations gaps knowledge, providing framework enhancing our understanding physiological effects on obesity. image

Language: Английский

Citations

1