Pyroptosis in health and disease: mechanisms, regulation and clinical perspective

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

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Active ingredients of traditional Chinese medicine inhibit NOD-like receptor protein 3 inflammasome: a novel strategy for preventing and treating heart failure

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 24, 2025

Heart failure (HF) has emerged as a significant global public health challenge owing to its high rates of morbidity and mortality. Activation the NOD-like receptor protein 3 (NLRP3) inflammasome is regarded pivotal factor in onset progression HF. Therefore, inhibiting activation NLRP3 may represent promising therapeutic approach for preventing treating The active ingredients serve foundation effects traditional Chinese medicine (TCM). Recent research revealed advantages TCM enhancing cardiac structure function study aimed explore impact on HF, review current advancements utilizing inhibit This provides novel perspective future development precise intervention strategies targeting prevent treat

Language: Английский

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Tamibarotene directly targets the NACHT domain of NLRP3 to alleviate acute myocardial infarction

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116801 - 116801

Published: Feb. 1, 2025

Language: Английский

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SEMA6D modulates extracellular matrix metabolism in osteoarthritis by inhibiting the AGT/AGTR1a/IL‐1β axis

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)

Published: April 4, 2025

Abstract The tissue‐localized renin‐angiotensin system (tRAS) plays a pivotal role in the crosstalk between cardiovascular factors and osteoarthritis (OA). Semaphorin 6D (SEMA6D), neuroeffector, may contribute to chondrocyte homeostasis; however, its cartilage‐specific functions remain unclear. Chondrocytes with altered SEMA6D expression were established via gene transfection. RNA sequencing was performed identify SEMA6D‐related genes pathways, preliminary validation human OA samples. Furthermore, biochemical methods employed investigate of AGT/AGTR1a/IL‐1β axis mediating SEMA6D‐associated extracellular matrix metabolism (ECM). An AAV5‐based lentiviral vector used generate rat models overexpressing SEMA6D, followed by radiological histological analyses. overexpression significantly enhanced ECM homeostasis, marked increased Aggrecan, COL2A1 decreased COL10A1, MMP13, Runx2 expression. These SEMA6D‐induced enriched tRAS pathway, AGT, AGTR1a, IL‐1β identified as critical targets. activated degradation chondrocytes, while effectively suppressed this signaling. In model, elevated reduced cartilage degradation. confers chondroprotective effects modulating likely through inhibition axis, thereby regulating hypertrophy. findings enhance our understanding influences on health reveal tissue‐specific regulatory mechanisms OA.

Language: Английский

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Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117367 - 117367

Published: Aug. 29, 2024

The pyroptosis of cardiomyocytes has become an essential topic in heart failure research. abnormal accumulation these biological factors, including angiotensin II, advanced glycation end products, and various growth factors (such as connective tissue factor, vascular endothelial transforming factor beta, among others), activates the nuclear factor-κB (NF-κB) signaling pathway cardiovascular diseases, ultimately leading to cardiomyocytes. Therefore, exploring underlying molecular mechanisms is for developing novel drugs therapeutic strategies. However, our current understanding precise regulatory mechanism this complex cardiomyocyte still limited. Given this, study reviews milestone discoveries field research since 1986, analyzes detail similarities, differences, interactions between other cell death modes apoptosis, necroptosis, autophagy, ferroptosis), explores deep connection failure. At same time, it depicts complete activation, transmission, eventual NF-κB process In addition, also systematically summarizes approaches that can inhibit reduce pyroptosis, drugs, natural compounds, small molecule inhibitors, gene editing, cutting-edge technologies, aiming provide solid scientific support new perspectives prevention treatment

Language: Английский

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Qian Yang Yu Yin Granule prevents hypertensive cardiac remodeling by inhibiting NLRP3 inflammasome activation via Nrf2

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118820 - 118820

Published: Sept. 1, 2024

Language: Английский

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