Brain, Journal Year: 2024, Volume and Issue: 147(5), P. 1622 - 1635
Published: Feb. 1, 2024
Cholesterol homeostasis is impaired in Alzheimer's disease; however, attempts to modulate brain cholesterol biology have not translated into tangible clinical benefits for patients date. Several recent milestone developments substantially improved our understanding of how excess neuronal contributes the pathophysiology disease. Indeed, was linked formation amyloid-β and neurofibrillary tangles through molecular pathways that were recently delineated mechanistic studies. Furthermore, remarkable advances translational imaging now made it possible probe metabolism living human with PET, which an important prerequisite future trials target machinery disease patients-with ultimate aim being develop disease-modifying treatments. This work summarizes current concepts biosynthesis, transport clearance are affected Further, strategies reverse these alterations by pharmacotherapy critically discussed wake emerging research tools support assessment only animal models but also
Language: Английский
Citations
12Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 99, P. 102389 - 102389
Published: June 19, 2024
Language: Английский
Citations
5Effect of electroacupuncture on MMP-2/9 pathway mediated the blood-brain barrier permeability in mice with Parkinson's disease
World Journal of Acupuncture - Moxibustion, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0Recent advances in blood-brain barrier-on-a-chip models
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0The Potential Role of Exosomes in Communication Between Astrocytes and Endothelial Cells
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4676 - 4676
Published: May 14, 2025
Exosomes are extracellular vesicles secreted by almost all types of cells. Their release allows for the transport specific regulatory cargo into recipient cells and modulation their activity. Vesicular communication has also been identified as an important mechanism regulation numerous cellular activities in brain tissue, contributing to proper neuronal functions homeostasis. In this work, we focus on role exosomes between astrocytes endothelial cells, two major components blood–brain barrier. We perform a comprehensive review latest studies highlighting astrocyte-endothelial cell crosstalk within have described particular exosomal miRNAs functions, discuss some future implications.
Language: Английский
Citations
0Oxyresveratrol reduces lipopolysaccharide-induced inflammation and oxidative stress through inactivation of MAPK and NF-κB signaling in brain endothelial cells
Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101823 - 101823
Published: Sept. 7, 2024
Language: Английский
Citations
2Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer’s disease mice with triple therapy
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 670, P. 125112 - 125112
Published: Dec. 27, 2024
Language: Английский
Citations
2Effect of Apolipoprotein E isoforms on the Abundance and Function of P-glycoprotein in Human Brain Microvascular Endothelial Cells
Pharmaceutical Research, Journal Year: 2024, Volume and Issue: 41(7), P. 1427 - 1441
Published: June 27, 2024
Individuals with Alzheimer's disease (AD) often require many medications; however, these medications are dosed using regimens recommended for individuals without AD. This is despite reduced abundance and function of P-glycoprotein (P-gp) at the blood-brain barrier (BBB) in AD, which can impact brain exposure drugs. The fundamental mechanisms leading to P-gp sporadic AD remain unknown; it known that apolipoprotein E (apoE) gene has strongest genetic link development, apoE isoforms differentially alter BBB function. aim this study was assess if affects an isoform-dependent manner a human cerebral microvascular endothelial cell (hCMEC/D3) model.
Language: Английский
Citations
0The role of ABCG2 in health and disease: Linking cancer therapy resistance and other disorders
Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123245 - 123245
Published: Nov. 1, 2024
Language: Английский
Citations
0Recent Advances in Blood Brain Barrier on Chip Models
Published: Jan. 1, 2024
Language: Английский
Citations
0