Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced Hearing Loss Therapy DOI
Binjun Chen,

Yanhong Sun,

Haojie Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Intense noise poses a threat to spiral ganglion neurons (SGNs) in the inner ear, often resulting limited axonal regeneration during injury and leading noise-induced hearing loss (NIHL). Here, we propose an ultrasound-triggered nitric oxide (NO) release enhance sprouting of injured axons SGNs. We developed hollow silicon nanoparticles load nitrosylated N-acetylcysteine, producing HMSN-SNO, which effectively protects NO from external interferences. Utilizing low-intensity ultrasound stimulation with bone penetration, achieve controlled HMSN-SNO within cochlea. In mice NIHL, rapid extensive synaptic connections between hair cells SGNs is observed 24 h after exposure excessive noise. However, this could be reversed combined treatment, functional recovery 83.57 65.00 dB SPL. This positive outcome attributed multifunctional effects wherein they scavenge reactive oxygen species (ROS) reverse pathological microenvironment simultaneously upregulate CREB/BDNF/EGR1 signaling pathway, thereby enhancing neuroplasticity promoting neuronal axons. These findings underscore potential nanomedicine for modulation, holds promise advancing both basic research further treatment neurological diseases.

Language: Английский

Ferroptosis and hearing loss: from molecular mechanisms to therapeutic interventions DOI Creative Commons
Xiaozhen Lv,

Chenyi Yang,

Xianying Li

et al.

Journal of Enzyme Inhibition and Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 24, 2025

Hearing loss profoundly affects social engagement, mental health, cognition, and brain development, with sensorineural hearing (SNHL) being a major concern. Linked to ototoxic medications, ageing, noise exposure, SNHL presents significant treatment challenges, highlighting the need for effective prevention regeneration strategies. Ferroptosis, distinct form of cell death featuring iron-dependent lipid peroxidation, has garnered interest due its potential role in cancer, neuronal degeneration, especially loss. The emerging ferroptosis as crucial mediator suggests that it may offer novel therapeutic target otoprotection. This review aims summarise intricate connection between SNHL, offering fresh perspective exploring targeted strategies could potentially mitigate cochlear cells damage enhance quality life individuals impairments.

Language: Английский

Citations

1
Metformin-induced mitophagy suppresses auditory hair cell apoptosis via AMPK pathway DOI Creative Commons
Yifan Lai, Jiawei Qiu, Zheng Kuang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 221, P. 111214 - 111214

Published: Jan. 16, 2025

Language: Английский

Citations

0
Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis DOI Creative Commons
Shasha Zhang,

Hairong Xiao,

Yanqin Lin

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Language: Английский

Citations

0
Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced Hearing Loss Therapy DOI
Binjun Chen,

Yanhong Sun,

Haojie Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

Intense noise poses a threat to spiral ganglion neurons (SGNs) in the inner ear, often resulting limited axonal regeneration during injury and leading noise-induced hearing loss (NIHL). Here, we propose an ultrasound-triggered nitric oxide (NO) release enhance sprouting of injured axons SGNs. We developed hollow silicon nanoparticles load nitrosylated N-acetylcysteine, producing HMSN-SNO, which effectively protects NO from external interferences. Utilizing low-intensity ultrasound stimulation with bone penetration, achieve controlled HMSN-SNO within cochlea. In mice NIHL, rapid extensive synaptic connections between hair cells SGNs is observed 24 h after exposure excessive noise. However, this could be reversed combined treatment, functional recovery 83.57 65.00 dB SPL. This positive outcome attributed multifunctional effects wherein they scavenge reactive oxygen species (ROS) reverse pathological microenvironment simultaneously upregulate CREB/BDNF/EGR1 signaling pathway, thereby enhancing neuroplasticity promoting neuronal axons. These findings underscore potential nanomedicine for modulation, holds promise advancing both basic research further treatment neurological diseases.

Language: Английский

Citations

2