Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species DOI Creative Commons
Man Zhu, Meng Ma,

Lunan Luo

et al.

Aging Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We found knocking down enzyme topoisomerase Top2 or its mammalian homolog TOP2B increases lifespan of S. cerevisiae , C. elegans mice. reduction also extends health span mice alleviates pathologies aging multiple tissues. At cellular/molecular level, major hallmarks aging, including senescence, damage, deregulated nutrient sensing. observed changes epigenetic landscape various tissues old toward young animals, differentially downregulates genes with active promoter high expression. Our observations suggest confers pro‐longevity effect across species possibly through a conserved mechanism may be promising strategy for longevity intervention.

Language: Английский

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species DOI Creative Commons
Man Zhu, Meng Ma,

Lunan Luo

et al.

Aging Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

ABSTRACT DNA topoisomerases are essential molecular machines that manage topology in the cell and play important roles replication transcription. We found knocking down enzyme topoisomerase Top2 or its mammalian homolog TOP2B increases lifespan of S. cerevisiae , C. elegans mice. reduction also extends health span mice alleviates pathologies aging multiple tissues. At cellular/molecular level, major hallmarks aging, including senescence, damage, deregulated nutrient sensing. observed changes epigenetic landscape various tissues old toward young animals, differentially downregulates genes with active promoter high expression. Our observations suggest confers pro‐longevity effect across species possibly through a conserved mechanism may be promising strategy for longevity intervention.

Language: Английский

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