Mechanistic insights into GLP-1 receptor agonist-induced weight loss through ceRNA network analysis

Genomics, Journal Year: 2025, Volume and Issue: 117(2), P. 110988 - 110988

Published: Jan. 5, 2025

GLP-1 receptor agonists (GLP-1RA) have been extensively utilized in the management of body weight individuals with obesity. Circular RNA (circRNA), a class covalently closed molecules, has garnered increasing attention for its potential role pathogenesis However, specific mechanisms through which circRNA contributes to GLP-1RA-induced loss remains elusive. High-throughput sequencing analyzed epididymal adipose tissue from obese mice under high-fat, and GLP-1RA intervention (600 μg/kg/d). The functions differentially expressed (DE) genes were enriched analyzed. circRNA-miRNA-mRNA interaction network was constructed Cytoscape, KEGG pathway gene enrichment validated via western blotting. A total 644 DEcircRNAs, 186 DEmiRNAs, 3474 DEmRNAs identified. Based on ceRNA score calculations, diagrams constructed. Gene Ontology (GO) analysis revealed that DERNAs linked lipid fatty acid metabolism. DE within pairs metabolism pathways, especially PI3K-Akt AMPK signaling pathways. induced phosphorylation AKT AMPK, subsequently led reduction SREBP-1, ACC, FAS. might activate pathways combat obesity circRNAs.

Language: Английский

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Semaglutide mitigates testicular damage in diabetes by inhibiting ferroptosis

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 715, P. 149996 - 149996

Published: April 24, 2024

Language: Английский

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NDUFS3 alleviates oxidative stress and ferroptosis in sepsis induced acute kidney injury through AMPK pathway

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113393 - 113393

Published: Oct. 18, 2024

Language: Английский

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AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists

Published: Jan. 10, 2025

Review AMPK-Mediated Multi-Organ Protective Effects of GLP-1 Receptor Agonists Xin Wang 1 and Linxi 2,* Emergency Department, Fujian Medical University Union Hospital, Fuzhou 350001, China 2 Department Endocrinology Metabolism, Institute Endocrinology, * Correspondence: [email protected] Received: 11 October 2024; Revised: 23 Accepted: 20 December Published: 9 January 2025 Abstract: AMP-activated protein kinase (AMPK) is a key enzyme broadly involved in regulating cellular metabolism, often called an “energy sensor”. Activated AMPK promotes ATP production storage within cells, primarily by inhibiting ATP-consuming anabolic processes (such as protein, lipid, ribosomal synthesis) initiating ATP-producing catabolic pathways fatty acid oxidation glycolysis) to maintain energy homeostasis. regulates metabolic various peripheral tissues, including glucose lipid cholesterol metabolism pancreatic β-cells, the cardiovascular system, liver, kidneys, skeletal muscles, central nervous system. As antidiabetic drug, multi-organ protective effects Glucagon-like peptide-1 receptor agonists (GLP-1RA) are increasingly being recognized. This paper reviews mechanisms which GLP-1RA confers organ protection via signaling pathway.

Language: Английский

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Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 7, 2025

Cardiovascular diseases represent the principal cause of death and comorbidity among people with diabetes. Ferroptosis, an iron-dependent non-apoptotic regulated cellular characterized by lipid peroxidation, is involved in pathogenesis diabetic cardiovascular diseases. The susceptibility to ferroptosis hearts possibly related myocardial iron accumulation, abnormal metabolism excess oxidative stress under hyperglycemia conditions. Accumulating evidence suggests can be therapeutic target for This review summarizes ferroptosis-related mechanisms novel choices targeting pathways. Further study on ferroptosis-mediated cardiac injury enhance our understanding pathophysiology provide more potential choices.

Language: Английский

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Targeting Ferroptosis in Parkinson’s: Repurposing Diabetes Drugs as a Promising Treatment

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1516 - 1516

Published: Feb. 11, 2025

This review explores the promising potential of repurposing type 2 diabetes (T2D) medications for treatment Parkinson's disease (PD), highlighting shared pathophysiological mechanisms between these two age-related conditions, such as oxidative stress, mitochondrial dysfunction, and ferroptosis. The overlap suggests that existing drugs could target common pathways involved in both conditions. Specifically, discusses how T2D medications, including metformin (Met), peroxisome-proliferator-activated receptor gamma (PPAR-γ) agonists, sodium-glucose cotransporter-2 (SGLT2) inhibitors, incretins, dipeptidyl-peptidase 4 (DPP-4) can improve function, reduce neuroinflammation potentially inhibit connection ferroptosis treatments, medication, are only beginning to be explored. limited data attributed also complexity fact specific role pathogenesis has not been a primary focus until recent. Despite preclinical evidence, clinical findings mixed, underscoring need further research elucidate drugs' roles neurodegeneration. Repurposing have well-established safety profiles significantly time cost associated with drug development offer more comprehensive approach managing compared treatments targeting single mechanism.

Language: Английский

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Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice

Peptides, Journal Year: 2025, Volume and Issue: unknown, P. 171366 - 171366

Published: Feb. 1, 2025

Language: Английский

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Effects of L-arginine supplementation on fat deposition and meat quality in growing lambs: Interactions with gut microbiota and metabolic signalling pathways

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 143677 - 143677

Published: March 1, 2025

Language: Английский

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GLP-1 as a regulator of sepsis outcomes: Insights into cellular metabolism, inflammation, and therapeutic potential

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114390 - 114390

Published: March 10, 2025

Language: Английский

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ACSL4 predicts rapid kidney function decline in patients with diabetic kidney disease

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Background Ferroptosis of kidney tubular epithelial cells contributes to the pathogenesis diabetic disease (DKD). An increase in enzyme long-chain fatty acid CoA ligase 4 (ACSL4) favors ferroptosis. However, association between ACSL4 renal tubules and outcomes patients with DKD is unknown. Methods To investigate predictive property rapid function decline DKD, a retrospective cohort 72 biopsy-proven were enrolled followed up for median 23 months. Tubular expression levels biopsy specimens from 12 control subjects measured using immunohistochemistry staining. The associations level clinical characteristics as well defined an estimated glomerular filtration rate (eGFR) slope ≤ -5 ml/min/1.73m 2 /year analyzed. Results was mainly expressed cells. significantly higher than those subjects. positively correlated proteinuria negatively albumin hemoglobin at time biopsy. During follow-up period, eGFR these -2.30 /year. slope. top tertile baseline found identify who high risk similar significant relationship continuous variable. Conclusions associated progression may serve novel pathological biomarker.

Language: Английский

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