The CB1 antagonist Rimonabant improves muscle regeneration and remodels the inflammatory and endocannabinoid profile upon injury in male mice DOI
Sebastiaan Dalle, Moniek Schouten,

Kaat Vanderbeke

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 361, P. 123296 - 123296

Published: Dec. 6, 2024

Language: Английский

Plant‐Derived Treatments for Different Types of Muscle Atrophy DOI Creative Commons
Xingpeng Wang,

Xiaofu Tang,

Yunhui Wang

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

With the development of medicine and chemistry, an increasing number plant-derived medicines have been shown to exert beneficial therapeutic on treatment various physical psychological diseases. In particular, by using chemistry methods, we are able examine chemical components plants effects these substances human body. Muscle atrophy (MA) is characterized decreased muscle mass function, caused multiple factors severely affects quality life patients. The multifactorial complex pathogenesis MA hinders drug research disease treatment. However, phytotherapy has achieved significant results in MA. We searched PubMed Web Science for articles related atrophy. After applying exclusion inclusion criteria, 166 79 met respectively. A total 173 were included study after excluding duplicates. important role phytoactives such as curcumin, resveratrol, ginsenosides (e.g., maintaining a positive nitrogen balance muscles exerting anti-inflammatory antioxidant effects) extensively studied. Unfortunately, dose not single cause, each cause its own unique mechanism injury. This review focuses mechanisms active plant provides insights into personalized

Language: Английский

Citations

0
The Role of Endocannabinoids in Physiological Processes and Disease Pathology: A Comprehensive Review DOI Open Access

Paulina Simankowicz,

Joanna Stępniewska

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2851 - 2851

Published: April 21, 2025

The endocannabinoid system is a complex communication involved in maintaining homeostasis various physiological processes, including metabolism, immune response, pain modulation, and neuroprotection. Endocannabinoids, mainly anandamide 2-arachidonoylglycerol, are natural ligands of the cannabinoid receptors CB1 CB2, which widely distributed throughout central nervous peripheral tissues. Their biosynthesis, degradation, interaction with other signaling pathways play crucial roles both health disease. This article provides comprehensive overview pathological endocannabinoids, discusses their potential as therapeutic targets, highlights recent advances endocannabinoid-based treatments.

Language: Английский

Citations

0
The molecular signature of the peripheral cannabinoid receptor 1 antagonist AM6545 in adipose, liver and muscle tissue DOI
Sebastiaan Dalle, Moniek Schouten,

Jolien Deboutte

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 491, P. 117081 - 117081

Published: Aug. 30, 2024

Language: Английский

Citations

2
The CB1 antagonist Rimonabant improves muscle regeneration and remodels the inflammatory and endocannabinoid profile upon injury in male mice DOI
Sebastiaan Dalle, Moniek Schouten,

Kaat Vanderbeke

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 361, P. 123296 - 123296

Published: Dec. 6, 2024

Language: Английский

Citations

0