The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Curcumin and bone marrow stem cells (BMSCs)-derived exosomes are considered to be useful for the treatment of many human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, role underlying molecular mechanism curcumin-loaded BMSCs-derived in progression SA-AKI remain unclear. Exosomes (BMSCs-EXO
Language: Английский
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103321 - 103321
Published: Aug. 19, 2024
Cell death constitutes a critical component of the pathophysiology cardiovascular diseases. A growing array non-apoptotic forms regulated cell (RCD)-such as necroptosis, ferroptosis, pyroptosis, and cuproptosis-has been identified is intimately linked to various conditions. These RCD are governed by genetically programmed mechanisms within cell, with epigenetic modifications being common crucial regulatory method. Such include DNA methylation, RNA histone acetylation, non-coding RNAs. This review recaps roles modifications, RNAs in diseases, well which regulate key proteins involved death. Furthermore, we systematically catalog existing pharmacological agents targeting novel their action article aims underscore pivotal role precisely regulating specific pathways thus offering potential new therapeutic avenues that may prove more effective safer than traditional treatments.
Language: Английский
Citations
7
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 30, 2025
Abstract BTB domain and CNC homolog 1 (BACH1) belongs to the family of basic leucine zipper proteins is expressed in most mammalian tissues. It can regulate its own expression play a role transcriptionally activating or inhibiting downstream target genes. has crucial various biological processes, such as oxidative stress, cell cycle, heme homeostasis, immune regulation. Recent research highlights BACH1's significant regulatory roles series conditions, including stem pluripotency maintenance differentiation, growth, senescence, apoptosis. BACH1 closely associated with cardiovascular diseases contributes angiogenesis, atherosclerosis, restenosis, pathological cardiac hypertrophy, myocardial infarction, ischemia/reperfusion (I/R) injury. promotes tumor proliferation metastasis by altering metabolism epithelial‐mesenchymal transition phenotype. Moreover, appears show an adverse neurodegenerative diseases, gastrointestinal disorders, leukemia, pulmonary fibrosis, skin diseases. Inhibiting may be beneficial for treating these This review summarizes mechanism different types proposing that precise targeted intervention provide new strategies human disease prevention treatment.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 247 - 247
Published: Feb. 8, 2025
N6-methyladenosine (m6A) is the most prevalent internal chemical modification in eukaryotic messenger RNA (mRNA), significantly impacting its lifecycle through dynamic and reversible processes involving methyltransferase, demethylase, binding proteins. These regulate mRNA stability, splicing, nuclear export, translation, degradation. Programmed cell death (PCD), a tightly controlled process encompassing apoptosis, pyroptosis, ferroptosis, autophagy, necroptosis, plays crucial role maintaining cellular homeostasis, tissue development, function. Recently, m6A has emerged as significant research area due to regulating PCD implications cardiovascular diseases (CVDs). In this review, we delve into intricate relationship between various types modification, emphasizing their pivotal roles initiation progression of CVDs such myocardial ischemia-reperfusion (I/R), atherosclerosis (AS), pulmonary hypertension (PH), cardiomyopathy, doxorubicin (Dox)-induced cardiotoxicity (DIC), heart failure (HF), infarction (MI). Our findings underscore potential elucidating CVD pave new pathways for prevention treatment strategies.
Language: Английский
Citations
0
Bone Research, Journal Year: 2025, Volume and Issue: 13(1)
Published: Feb. 25, 2025
Abstract The muscular system plays a critical role in the human body by governing skeletal movement, cardiovascular function, and activities of digestive organs. Additionally, muscle tissues serve an endocrine function secreting myogenic cytokines, thereby regulating metabolism throughout entire body. Maintaining requires iron homeostasis. Recent studies suggest that disruptions ferroptosis, form iron-dependent cell death, are essential contributors to progression wide range diseases disorders, including sarcopenia, cardiomyopathy, amyotrophic lateral sclerosis. Thus, comprehensive overview mechanisms ferroptosis these conditions is crucial for identifying potential therapeutic targets developing new strategies disease treatment and/or prevention. This review aims summarize recent advances understanding molecular underlying context injury, as well associated disorders. Moreover, we discuss within pathway possible managing Finally, shed light on current limitations future prospects interventions targeting ferroptosis.
Language: Английский
Citations
0
Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156783 - 156783
Published: April 1, 2025
Language: Английский
Citations
0
Epigenomics, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13
Published: April 19, 2025
Sepsis, a severe systemic inflammatory condition triggered by infection, is associated with high morbidity and mortality worldwide. While medical diagnosis treatment have advanced in recent years, specific therapy remains unavailable. Recently, significant progress has been made studying the epigenetic RNA modification N6-methyladenosine (m6A) its core methyltransferase METTL3. The role of m6A sepsis also increasingly elucidated. This review aims to explore pathological mechanisms relationship m6A, focusing on key writer, METTL3, sepsis.
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Dec. 18, 2024
Fat mass and obesity-associated (FTO) protein, a key enzyme integral to the dynamic regulation of epitranscriptomic modifications in RNAs, significantly influences crucial RNA lifecycle processes, including splicing, export, decay, translation. The role FTO altering epitranscriptome manifests across spectrum physiological pathological conditions. This review aims consolidate current understanding regarding implications health disease, with special emphasis on its involvement obesity non-communicable diseases associated obesity, such as diabetes, cardiovascular cancer. It also summarizes established molecules FTO-inhibiting activity. Given extensive impact both physiology pathophysiology, this overview provides illustrative insights into roles, rather than an exhaustive account. A proper function human could lead new treatment approaches, potentially unlocking novel avenues for addressing metabolic disorders malignancies. evolving FTO's regulatory mechanisms hold great promise future advancements disease prevention.
Language: Английский
Citations
3
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0
The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Curcumin and bone marrow stem cells (BMSCs)-derived exosomes are considered to be useful for the treatment of many human diseases, including sepsis-associated acute kidney injury (SA-AKI). However, role underlying molecular mechanism curcumin-loaded BMSCs-derived in progression SA-AKI remain unclear. Exosomes (BMSCs-EXO
Language: Английский
Citations
0