Complex origins of chloroplast membranes with photosynthetic machineries: multiple transfers of genes from divergent organisms at different times or a single endosymbiotic event? DOI Creative Commons
Naoki Sato

Journal of Plant Research, Journal Year: 2019, Volume and Issue: 133(1), P. 15 - 33

Published: Dec. 6, 2019

Abstract The paradigm “cyanobacterial origin of chloroplasts” is currently viewed as an established fact. However, we may have to re-consider the chloroplast membranes, because membranes are not replicated by their own. It genes for lipid biosynthetic enzymes that inherited. In current understandings, these became encoded nuclear genome a result endosymbiotic gene transfer from endosymbiont. previously showed many involved in synthesis peptidoglycan and glycolipids did originate cyanobacteria. Here I present results comprehensive phylogenetic analysis fatty acid biosynthesis, well additional components related photosynthesis expression. Four types relationship between (encoded genomes) cyanobacterial counterparts were found: type 1, diverged inside clade; 2, sister groups; 3, originated homologs bacteria other than cyanobacteria; 4, eukaryotic homologs. Estimation evolutionary distances suggested acquisition times diverse, indicating multiple transfers accounted analyzed. Based on results, try relax tight logic chloroplasts involving single event proposing alternative hypotheses. hypothesis host-directed formation proposes glycolipid ability had been acquired host before ribosomes. Chloroplast membrane system could provided host, whereas cyanobacteria contributed genetic systems, at various times, either or after membranes. origin(s) seems be more complicated primary endosymbiosis.

Language: Английский

Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties DOI Creative Commons
Ronan Lordan, Αλέξανδρος Τσούπρας, Ioannis Zabetakis

et al.

Molecules, Journal Year: 2017, Volume and Issue: 22(11), P. 1964 - 1964

Published: Nov. 14, 2017

In this review paper, the latest literature on functional properties of phospholipids in relation to inflammation and inflammation-related disorders has been critically appraised evaluated. The paper is divided into three sections: Section 1 presents an overview relationship between structures biological activities (pro-inflammatory or anti-inflammatory) several with respect inflammation. 2 3 are dedicated structures, functions, compositions anti-inflammatory dietary from animal marine sources. Most origin come meat, egg dairy products. To date, there very limited work published meat phospholipids, undoubtedly due negative perception that consumption unhealthy option because its putative associations chronic diseases. These assumptions addressed phospholipid composition Recent research trends indicate possess properties, which led increased interest their molecular reputed health benefits. Finally, structural discussed. Extensive ω-3 polyunsaturated fatty acids (PUFAs) inflammation, however recently under scrutiny proved be unreliable controversial terms therapeutic effects PUFA, generally form triglycerides esters. Therefore, focuses recent publications concerning related strong nutritional value highlighted avenues for future

Language: Английский

Citations

239
The cell biology of archaea DOI
Marleen van Wolferen, André A. Pulschen, Buzz Baum

et al.

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(11), P. 1744 - 1755

Published: Oct. 17, 2022

Language: Английский

Citations

74
CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications DOI Creative Commons
Shasha Feng, Soohyung Park, Yeol Kyo Choi

et al.

Journal of Chemical Theory and Computation, Journal Year: 2023, Volume and Issue: 19(8), P. 2161 - 2185

Published: April 4, 2023

Molecular dynamics simulations of membranes and membrane proteins serve as computational microscopes, revealing coordinated events at the interface. As G protein-coupled receptors, ion channels, transporters, membrane-bound enzymes are important drug targets, understanding their binding action mechanisms in a realistic becomes critical. Advances materials science physical chemistry further demand an atomistic lipid domains interactions between membranes. Despite wide range simulation studies, generating complex assembly remains challenging. Here, we review capability CHARMM-GUI

Language: Английский

Citations

45
Engineering microbial membranes to increase stress tolerance of industrial strains DOI
Yanli Qi, Hui Liu, Xiulai Chen

et al.

Metabolic Engineering, Journal Year: 2018, Volume and Issue: 53, P. 24 - 34

Published: Dec. 31, 2018

Language: Английский

Citations

119
Discovery, structure and mechanism of a tetraether lipid synthase DOI Creative Commons
Cody T. Lloyd, David F. Iwig, Bo Wang

et al.

Nature, Journal Year: 2022, Volume and Issue: 609(7925), P. 197 - 203

Published: July 26, 2022

Archaea synthesize isoprenoid-based ether-linked membrane lipids, which enable them to withstand extreme environmental conditions, such as high temperatures, salinity, and low or pH values1-5. In some archaea, Methanocaldococcus jannaschii, these lipids are further modified by forming carbon-carbon bonds between the termini of two lipid tails within one glycerophospholipid generate macrocyclic archaeol from glycerophospholipids macrocycle glycerol dibiphytanyl tetraether (GDGT)1,2. GDGT contains 40-carbon chains (biphytanyl chains) that span both leaflets membrane, providing enhanced stability conditions. How specialized formed has puzzled scientists for decades. The reaction necessitates coupling completely inert sp3-hybridized carbon centres, which, our knowledge, not been observed in nature. Here we show gene product mj0619 M. encodes a radical S-adenosylmethionine enzyme, is responsible biphytanyl chain formation during synthesis lipids6. Structures enzyme presence four metallocofactors: three [Fe4S4] clusters mononuclear rubredoxin-like iron ion. vitro mechanistic studies Csp3-Csp3 bond takes place on fully saturated archaeal substrates involves an intermediate substrate sulfur clusters. Our results only establish biosynthetic route but also improve use GDGT-based paleoclimatology indices7-10.

Language: Английский

Citations

52
Methyl-Based Methanogenesis: an Ecological and Genomic Review DOI
Clifton P. Bueno de Mesquita, Dongying Wu, Susannah G. Tringe

et al.

Microbiology and Molecular Biology Reviews, Journal Year: 2023, Volume and Issue: 87(1)

Published: Jan. 24, 2023

Methyl-based methanogenesis is one of three broad categories archaeal anaerobic methanogenesis, including both the methyl dismutation (methylotrophic) pathway and methyl-reducing (also known as hydrogen-dependent methylotrophic) pathway. increasingly recognized an important source methane in a variety environments.

Language: Английский

Citations

38
Minimal Out-of-Equilibrium Metabolism for Synthetic Cells: A Membrane Perspective DOI Creative Commons

Eleonora Bailoni,

Michele Partipilo, Jelmer Coenradij

et al.

ACS Synthetic Biology, Journal Year: 2023, Volume and Issue: 12(4), P. 922 - 946

Published: April 7, 2023

Life-like systems need to maintain a basal metabolism, which includes importing variety of building blocks required for macromolecule synthesis, exporting dead-end products, and recycling cofactors metabolic intermediates, while maintaining steady internal physical chemical conditions (physicochemical homeostasis). A compartment, such as unilamellar vesicle, functionalized with membrane-embedded transport proteins enzymes encapsulated in the lumen meets these requirements. Here, we identify four modules designed minimal metabolism synthetic cell lipid bilayer boundary: energy provision conversion, physicochemical homeostasis, metabolite transport, membrane expansion. We review design strategies that can be used fulfill functions focus on protein composition cell. compare our bottom-up equivalent essential JCVI-syn3a, top-down genome-minimized living size comparable large vesicles. Finally, discuss bottlenecks related insertion complex mixture into bilayers provide semiquantitative estimate relative surface area lipid-to-protein mass ratios (i.e., number proteins) are construction

Language: Английский

Citations

27
Accelerating the discovery of alkyl halide-derived natural products using halide depletion DOI Creative Commons
Nathaniel R. Glasser,

Dongtao Cui,

Douglas D. Risser

et al.

Nature Chemistry, Journal Year: 2024, Volume and Issue: 16(2), P. 173 - 182

Published: Jan. 12, 2024

Even in the genomic era, microbial natural product discovery workflows can be laborious and limited their ability to target molecules with specific structural features. Here we leverage an understanding of biosynthesis develop a workflow that targets alkyl halide-derived products by depleting halide anions, key biosynthetic substrate for enzymatic halogenation, from growth media. By comparing metabolomes bacterial cultures grown halide-replete deficient media, rapidly discovered nostochlorosides, orphan halogenase-encoding gene cluster Nostoc punctiforme ATCC 29133. We further found these products, family unusual chlorinated glycolipids featuring rare sugar gulose, are polymerized via unprecedented etherification reaction. Together, our results highlight power leveraging logic streamline discovery.

Language: Английский

Citations

9
Archaeal cell surface biogenesis DOI Creative Commons
Mechthild Pohlschröder, Friedhelm Pfeiffer, Stefan Schulze

et al.

FEMS Microbiology Reviews, Journal Year: 2018, Volume and Issue: 42(5), P. 694 - 717

Published: June 12, 2018

Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability surface attachment. While certain aspects the mechanisms supporting biosynthesis archaeal unique, likely due important differences in compositions between domains, others shared with bacteria or eukaryotes both. Based on recent studies completed a phylogenetically array archaea, wide variety habitats, here we discuss advances characterization underpinning biogenesis. These include those facilitating co- post-translational protein targeting surface, transport into lipid membrane, anchoring strategies. We also discuss, some detail, assembly specific structures, such as S-layer type IV pili. will highlight importance modifications, attachment glycosylation, well regulation these structures present similarities biogenesis pili prokaryotic domains.

Language: Английский

Citations

71
Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties DOI Open Access
Ronan Lordan, Αλέξανδρος Τσούπρας, Ioannis Zabetakis

et al.

Published: Nov. 6, 2017

In this review paper, the latest literature on functional properties of phospholipids in relation to inflammation and inflammation-related disorders has been critically appraised evaluated. The paper is divided into three sections: Section one addresses relationship between anti-inflammatory bioactivities different their structures compositions. Sections two are dedicated structures, functions dietary from animal marine sources. Most origin come meat, egg dairy products. To date, there very limited work published meat phospholipids, undoubtedly due negative perception that consumption an unhealthy option its putative associations with several chronic diseases. These assumptions addressed respect phospholipid composition Recent research trends indicate possess properties, which led increased interest molecular reputed health benefits. Finally, structural discussed. Extensive ω-3 polyunsaturated fatty acids (PUFAs) inflammation, however recently under scrutiny proved be unreliable controversial terms therapeutic effects PUFA, generally form triglycerides esters. Therefore, focuses recent publications concerning related strong nutritional value highlighted avenues for future

Language: Английский

Citations

69