The current state and problems of studying the biological effects of THz irradiation DOI Creative Commons
Е. А. Бутикова, И. А. Разумов, О. В. Повещенко

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2025, Volume and Issue: 10(2), P. 33 - 47

Published: May 19, 2025

Background. Teraher tz r adiation (THz), which occupies the frequency range from 0.1 to 10 THz, has been a topic of limited research for long time due difficulty in creating sources and detecting it. Recent advancements semiconductor nanotechnology, however, have led development THz technologies areas such as communications, medicine, safety. Nevertheless, there are concerns about potential health environmental effects these technologies. The aim. Summariz e current state resear ch fi c ellular eff ts arising fr om exp osure t o TH z. Special att ention is paid use ffi technologies, particular metabolomics, proteomics, transcriptomics study on living systems. review also aims analyze key patterns biological caused by assess prospects further application biomedical biotechnological direction features experiment organization infl THz. To write review, search scientifi publications was carried out using PubMed, Google Scholar, Scopus, IEEE Xplore period 2000 2024. Discussion. studies hav shown non-thermal ells, including genotoxicity changes gene expr ession. Ho wever, results vary depending con ditions ell yp es used . Most b een conducted vitro various cell lines, depend radiation parameters wavelength intensity. For epithelial cells fibroblasts, cytotoxicity generally low at 1 although genotoxic cannot be ruled out. reduce DNA methylation tumor cells, could useful diagnosis. Omics helping molecular mechanisms underlying effects, but standardizing methods crucial accurately differentiate between thermal mechanisms. Conclusion. T he emphasiz importance its impact However, available data dispersed. comprehend detailed experimental investigations required, metabolomics approaches analyzing biochemical responses radiation.

Language: Английский

The current state and problems of studying the biological effects of THz irradiation DOI Creative Commons
Е. А. Бутикова, И. А. Разумов, О. В. Повещенко

et al.

Acta Biomedica Scientifica (East Siberian Biomedical Journal), Journal Year: 2025, Volume and Issue: 10(2), P. 33 - 47

Published: May 19, 2025

Background. Teraher tz r adiation (THz), which occupies the frequency range from 0.1 to 10 THz, has been a topic of limited research for long time due difficulty in creating sources and detecting it. Recent advancements semiconductor nanotechnology, however, have led development THz technologies areas such as communications, medicine, safety. Nevertheless, there are concerns about potential health environmental effects these technologies. The aim. Summariz e current state resear ch fi c ellular eff ts arising fr om exp osure t o TH z. Special att ention is paid use ffi technologies, particular metabolomics, proteomics, transcriptomics study on living systems. review also aims analyze key patterns biological caused by assess prospects further application biomedical biotechnological direction features experiment organization infl THz. To write review, search scientifi publications was carried out using PubMed, Google Scholar, Scopus, IEEE Xplore period 2000 2024. Discussion. studies hav shown non-thermal ells, including genotoxicity changes gene expr ession. Ho wever, results vary depending con ditions ell yp es used . Most b een conducted vitro various cell lines, depend radiation parameters wavelength intensity. For epithelial cells fibroblasts, cytotoxicity generally low at 1 although genotoxic cannot be ruled out. reduce DNA methylation tumor cells, could useful diagnosis. Omics helping molecular mechanisms underlying effects, but standardizing methods crucial accurately differentiate between thermal mechanisms. Conclusion. T he emphasiz importance its impact However, available data dispersed. comprehend detailed experimental investigations required, metabolomics approaches analyzing biochemical responses radiation.

Language: Английский

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