Iron homeostasis and oxidative stress: An intimate relationship

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2019, Volume and Issue: 1866(12), P. 118535 - 118535

Published: Aug. 22, 2019

Language: Английский

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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

Cell Research, Journal Year: 2018, Volume and Issue: 28(12), P. 1171 - 1185

Published: Oct. 4, 2018

Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and participate in different modes of cell death, such as ferroptosis, apoptosis necroptosis. However, whether iron-elevated ROS is also linked pyroptosis not reported. Here, we demonstrate that iron-activated can induce via a Tom20-Bax-caspase-GSDME pathway. In melanoma cells, iron enhanced signaling initiated CCCP, causing the oxidation oligomerization mitochondrial outer membrane protein Tom20. Bax recruited mitochondria oxidized Tom20, which facilitates cytochrome c release cytosol activate caspase-3, eventually triggering pyroptotic death inducing GSDME cleavage. Therefore, acts causative factor Tom20 senses for iron-driven cells. Since activates GSDME-dependent induction cells specifically express high level GSDME, may be potential candidate therapy. Based on functional mechanism above, further supplementation at dosage used iron-deficient patients sufficient maximize anti-tumor effect clinical ROS-inducing drugs inhibit xenograft tumor growth metastasis through pyroptosis. Moreover, no obvious side effects are observed normal tissues organs mice during combined treatment iron. This study only identifies sensitizer amplifying drive pyroptosis, but implicates novel iron-based intervention strategy

Language: Английский

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Additively manufactured biodegradable porous iron

Acta Biomaterialia, Journal Year: 2018, Volume and Issue: 77, P. 380 - 393

Published: July 6, 2018

Language: Английский

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Heavy metals levels in raw cow milk and health risk assessment across the globe: A systematic review

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 751, P. 141830 - 141830

Published: Aug. 21, 2020

Language: Английский

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Targeting iron metabolism in cancer therapy

Theranostics, Journal Year: 2021, Volume and Issue: 11(17), P. 8412 - 8429

Published: Jan. 1, 2021

Iron is a critical component of many cellular functions including DNA replication and repair, it essential for cell vitality.As an element, iron maintaining human health.However, excess can be highly toxic, resulting in oxidative damage.Many studies have observed significant associations between cancer, the association appears to more than just coincidental.The chief characteristic cancers, hyper-proliferation, makes them even dependent on normal cells.Cancer therapeutics are becoming as diverse disease itself.Targeting metabolism cancer cells emerging, formidable field therapeutics.It strategy that with regard specific targets various ways reach them.This review will discuss importance highlight which being explored medicine tomorrow.

Language: Английский

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Bacterial survival strategies and responses under heavy metal stress: a comprehensive overview

Critical Reviews in Microbiology, Journal Year: 2021, Volume and Issue: 48(3), P. 327 - 355

Published: Sept. 2, 2021

Heavy metals bring long-term hazardous consequences and pose a serious threat to all life forms. Being non-biodegradable, they can remain in the food webs for long period of time. Metal ions are essential indispensable almost aspects metabolism but be toxic beyond threshold level living beings including microbes. generally present environment, many geogenic anthropogenic activities has led excess metal ion accumulation environment. To survive harsh contaminated environments, bacteria have certain resistance mechanisms metabolize transform heavy into less This also gives rise different species resistant bacteria. Herein, we tried incorporate toxicity provide an up-to-date across-the-board review. The various biology encompassed this review includes biological notion metals, effect on bacteria, factors regulating bacterial resistance, diverse governing responses stress, brief overview gene regulation under stress.

Language: Английский

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Highly fluorescent carbon dots derived from Mangifera indica leaves for selective detection of metal ions

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 720, P. 137604 - 137604

Published: Feb. 26, 2020

Language: Английский

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Ferroptosis in life: To be or not to be

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 159, P. 114241 - 114241

Published: Jan. 10, 2023

Ferroptosis is a novel type of programmed cell death, characterized by dysregulated iron metabolism and accumulation lipid peroxides. It features the alteration mitochondria aberrant excessive as well loss cysteine-glutathione-GPX4 axis. Eventually, accumulated peroxides result in lethal damage to cells. induced overloading ROS can be inhibited activation GPX4 pathway, FS1-CoQ10 GCH1-BH4 DHODH it also regulated oncogenes tumor suppressors. involves various physiological pathological processes, increasing evidence indicates that ferroptosis play critical role cancers other diseases. inhibits proliferation malignant cells types inducing may become new method cancer treatment. Many inhibitors targeting key factors such SLC7A11, GPX4, overload have been developed. The application mainly divided into two directions, i.e. avoid healthy selectively induce cancers. In this review, we provide analysis concept, regulation pathways explored its roles diseases, summarized compounds ferroptosis, aiming promote speed clinical use induction

Language: Английский

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The Metabolic Syndrome, a Human Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251

Published: Feb. 13, 2024

This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.

Language: Английский

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Anemia, iron, and HIV: decoding the interconnected pathways: A review

Medicine, Journal Year: 2024, Volume and Issue: 103(2), P. e36937 - e36937

Published: Jan. 12, 2024

This review delves into the intricate relationship between anemia, iron metabolism, and human immunodeficiency virus (HIV), aiming to unravel interconnected pathways that contribute complex interplay these 3 entities. A systematic exploration of relevant literature was conducted, encompassing studies examining association status, HIV infection. Both clinical preclinical investigations were analyzed elucidate underlying mechanisms linking components. Chronic inflammation, a hallmark infection, disrupts homeostasis, impacting erythropoiesis contributing anemia. Direct viral effects on bone marrow function further compound red blood cell deficiencies. Antiretroviral therapy, while essential for managing HIV, introduces potential complications, including medication-induced Dysregulation levels in different tissues adds complexity network interactions. Effective management anemia necessitates multifaceted approach. Optimization antiretroviral treatment opportunistic infections, targeted nutritional interventions, supplementation, are integral However, challenges persist understanding specific molecular governing pathways. Decoding is imperative enhancing holistic care individuals with HIV/AIDS. nuanced relationships will inform development more precise optimizing this population. Future research endeavors should focus elucidating mechanisms, paving way innovative therapeutic strategies context HIV-associated

Language: Английский

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