Unlocking the potential of flavonoids: Natural solutions in the fight against colon cancer

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116827 - 116827

Published: June 10, 2024

Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, underscoring the importance understanding diverse molecular and genetic underpinnings CRC to improve its diagnosis, prognosis, treatment. This review delves into adenoma-carcinoma-metastasis model, emphasizing "APC-KRAS-TP53" signature events in development. categorized four consensus subtypes, each characterized by unique alterations responses therapy, illustrating complexity heterogeneity. Furthermore, we explore role chronic inflammation gut microbiome progression, potential targeting these factors for prevention discusses impact dietary carcinogens lifestyle critical early detection improving outcomes, also examines conventional chemotherapy options associated challenges. There significant focus on therapeutic flavonoids management, discussing various types flavonoids, their sources, mechanisms action, including antioxidant properties, modulation cell signaling pathways, effects cycle apoptosis. article presents evidence synergistic with therapies modulating immune response, thereby offering new avenues We conclude multidisciplinary approach research treatment, incorporating insights from genetic, molecular, factors. Further needed preventive natural compounds, such as CRC, need personalized targeted treatment strategies.

Language: Английский

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Chrysanthemum indicum L. ameliorates muscle atrophy by improving glucose tolerance in CT26-induced cancer cachexia

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 18, 2024

Introduction Cancer cachexia is associated with various metabolic mechanisms such as inflammatory response, insulin resistance, and increased muscle proteolysis. However, effective treatment methods have not yet been standardized. Chrysanthemum indicum L . (CI) a perennial plant belonging to the Asteraceae family, its flowers used for of headaches, colds, rhinitis in Asia. Methods This study investigated effect CI on cancer cachexia. We subcutaneously injected CT26 colon cells (5 × 10 5 cells/mouse) into right flank BALB/c mice. After 1 week, mice were orally administered vehicle, (100 mg/kg), or Celecoxib (50 mg/kg) 3 weeks. Results improved loss body weight impaired glucose tolerance, but celecoxib did recover intolerance. only decreased myofiber diameters also inhibited protein degradation factors, MAFbx MuRF1. cellular membrane GLUT4 conditioned medium-treated C2C12 myofibers cachexia-induced Furthermore, we found that linarin, constituent CI, was responsible improvement atrophy. Conclusion Our findings indicate can ameliorate atrophy by improving uptake, suggesting could be therapeutic agent

Language: Английский

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Amelioration of Cancer Cachexia by Dalbergia odorifera Extract Through AKT Signaling Pathway Regulation

Nutrients, Journal Year: 2024, Volume and Issue: 16(21), P. 3671 - 3671

Published: Oct. 28, 2024

Background/Objectives: Cancer cachexia is a multifactorial syndrome characterized by the progressive loss of skeletal muscle mass and adipose tissue. Dalbergia odorifer widely used in traditional medicine Korea China to treat various diseases. However, its exact role underlying mechanism regulating cancer have not been elucidated yet. This research was conducted investigate effect D. extract (DOE) preventing development cancer-induced symptoms figure out relevant mechanisms. Methods: A model established Balb/c mice using CT26 colon carcinoma cell line. To evaluate anti-cachexia (DOE), CT26-bearing were orally administered with DOE at concentrations 50 100 mg/kg BW for 14 days. C2C12 myotubes 3T3L1 adipocytes treated 80% conditioned medium, DOE, wortmannin, particular AKT inhibitor determine influence signaling pathway. Mice body weight, food intake, myofiber cross-sectional area, adipocyte size, myotube diameter, lipid accumulation, gene expression analyzed. Results: The oral administration doses weight tumor-bearing resulted significant reduction loss, an increase decrease serum glycerol levels. Furthermore, treatment led mass, larger fiber elevated levels MyH2 Igf1, while simultaneously reducing Atrogin1 MuRF1. also attenuated tissue wasting, as evidenced increased epididymal fat enlarged upregulated Pparγ expression, alongside Ucp1 IL6 In cachectic 3T3-L1 induced significantly inhibited wasting lipolysis activating specific inhibitor, effectively neutralized DOE’s impact on pathway, accumulation. Conclusions: ameliorates through genes involved protein synthesis lipogenesis, suppressing those related degradation, suggesting potential plant-derived therapeutic agent combating cachexia.

Language: Английский

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Baicalein, a natural flavonoid in gastrointestinal cancers treatment: recent trends and future perspectives

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 24, 2024

Language: Английский

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