Genotoxicity Assessment of Co(II) and Ni(II) in HepG2 Cells: Insights into Combined Metal Exposure DOI
Alicia Thiel,

Sarah Heider,

Kira Bieck

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

The usage of cobalt (Co) and nickel (Ni) in numerous commercial, industrial, military applications causes widespread exposure nowadays, concerns are rising about adverse impacts on human health. Emphasis is the respiratory system, with both metals classified as (possibly) carcinogenic upon inhalation by International Agency for Research Cancer (IARC), but limited data available oral exposure. Therefore, this study aims to evaluate vitro genotoxicity Co(II) Ni(II) their combination HepG2 cells, since those environmental pollutants occurs realistically concert. Here, led induction single-strand breaks oxidative DNA damage detected Comet assay FPG-sensitive sites, while increased abundance γ-H2AX, an indicator double-strand breaks. Notably, combined resulted enhanced damage, especially at chromosomal level, formation micronuclei well polynucleated indicating a stronger effect compared single Furthermore, induced response pathway PARylation. As process involves consumption large amounts cellular NAD+ after energy state was assessed Ni(II). Current indicate that altered state. This reveals distinct mechanisms exhibited Ni(II), which were treatment. highlights need further research estimate genotoxic potential targeting cells intake increasing entry.

Language: Английский

An integrated approach to quantify ecological and human health risks of soil heavy metal contamination around coal mining area DOI
Teklit Zerizghi,

Qingjun Guo,

Liyan Tian

et al.

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 814, P. 152653 - 152653

Published: Dec. 23, 2021

Language: Английский

Citations

143
Bone Tissue Engineering Scaffolds: Function of Multi‐Material Hierarchically Structured Scaffolds DOI Creative Commons

Tejas M. Koushik,

Catherine Miller, Elsa Antunes

et al.

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 12(9)

Published: Dec. 13, 2022

Bone tissue engineering (BTE) is a topic of interest for the last decade, and advances in materials, processing techniques, understanding bone healing pathways have opened new avenues research. The dual responsibility BTE scaffolds providing load-bearing capability interaction with local extracellular matrix to promote challenge synthetic scaffolds. This article describes usage multi-materials hierarchical structures mimic structure natural tissues function as bioactive first part this literature review physiology responses interactions at different stages repair. following section reviews available on biomaterials used followed by some multi-material approaches. next discusses impact scaffold's structural features necessity distribution scaffold structure. Finally, highlights emerging trends developments that can inspire strategies truly develop generation

Language: Английский

Citations

131
Heavy Metals – Definition, Natural and Anthropogenic Sources of Releasing into Ecosystems, Toxicity, and Removal Methods – An Overview Study DOI Open Access
Waleed Jadaa, Hamad Mohammed

Journal of Ecological Engineering, Journal Year: 2023, Volume and Issue: 24(6), P. 249 - 271

Published: April 26, 2023

The constant discharge of large quantities toxic substances due to human activities has led a global environmental issue.Numerous industrial sectors' effluents, which include coal-based power plants, mineral extraction activities, electroplating processes, as well battery manufacturing, release metallic ions towards different ecosystems, such Cadmium (Cd), Mercury (Hg), and Chromium (Cr).Heavy metals pose significant danger living organisms, humans, environments because their properties, mainly severe toxicity, strong accumulation ability.Metallic are not subject breakdown final components when contrasted with organic contaminants, significantly impacted by biochemical chemical decomposition.Consequently, eliminating these elements been regarded task within the water treatment sector.The purpose this article is analyze literature related heavy in terms issues.The expression explained.The natural sources responsible for releasing into environment comprehensively discussed.In addition, toxicity potential risks humans ecosystems included.Various approaches removing from wastewater, along associated advantages drawbacks, further evaluated.

Language: Английский

Citations

55
Ecological impacts and potential hazards of nickel on soil microbes, plants, and human health DOI Creative Commons
Muhammad Rizwan, Kamal Usman, Mohammed Alsafran

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 142028 - 142028

Published: April 13, 2024

Nickel (Ni) contamination poses a serious environmental concern, particularly in developing countries: where, anthropogenic activities significantly contributes to Ni accumulations soils and waters. The of agricultural with Ni, increases risks its entry terrestrial ecosystems food production systems posing threat both security safety. We examined the existing published articles regarding origin, source, accumulation, transport soil environments. Particularly, we reviewed bioavailability toxic effects invertebrates microbes, as well impact on soil-plant interactions including seed germination, nutrient uptake, photosynthesis, oxidative stress, antioxidant enzyme activity, biomass production. Moreover, it underscores potential health hazards associated consuming crops cultivated Ni-contaminated elucidates pathways through which enters chain. literature suggests that chronic exposure may have long-term implications for supply chain public. Therefore, an aggressive effort is required interdisciplinary collaboration assessing mitigating ecological contamination. It also argues these measures are necessary light increasing level pollution impacts public environment.

Language: Английский

Citations

18
Simultaneous removal of nitrate, manganese, and tetracycline by Zoogloea sp. MFQ7: Adsorption mechanism of tetracycline by biological precipitation DOI
Qiao Chang, Amjad Ali, Junfeng Su

et al.

Bioresource Technology, Journal Year: 2021, Volume and Issue: 340, P. 125690 - 125690

Published: July 31, 2021

Language: Английский

Citations

59
Heavy metals distribution characteristics, source analysis, and risk evaluation of soils around mines, quarries, and other special areas in a region of northwestern Yunnan, China DOI
Xin Liu,

Huajian Chi,

Zhiqiang Tan

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 458, P. 132050 - 132050

Published: July 12, 2023

Language: Английский

Citations

29
Associations of metal mixtures with metabolic-associated fatty liver disease and non-alcoholic fatty liver disease: NHANES 2003–2018 DOI Creative Commons
Zhilan Xie,

Ruxianguli Aimuzi,

Mingyu Si

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: March 6, 2023

Objective The hepatotoxicity of exposure to a single heavy metal has been examined in previous studies. However, there is limited evidence on the association between metals mixture and non-alcoholic fatty liver disease (NAFLD) metabolic-associated (MAFLD). This study aims investigate associations 13 urinary metals, individually jointly, with NAFLD, MAFLD, MAFLD components. Methods included 5,548 adults from National Health Nutrition Examination Survey (NHANES) 2003–2018. Binary logistic regression was used explore individual exposures Bayesian kernel machine (BKMR) Quantile-based g-computation (QGC) were these outcomes. Results In analysis, increased levels arsenic [OR 1.09 (95%CI 1.03–1.16)], dimethylarsinic acid [1.17 1.07–1.27)], barium [1.22 1.14–1.30)], cobalt 1.11–1.34)], cesium [1.35 1.18–1.54)], molybdenum [1.45 1.30–1.62)], antimony [1.18 1.08–1.29)], thallium [1.49 1.33–1.67)], tungsten [1.23 1.15–1.32)] significantly associated risk after adjusting for potential covariates. results NAFLD similar those except arsenic, which insignificantly NAFLD. overall positively components, including obesity/overweight, diabetes, metabolic dysfunction. both BKMR QGC models, thallium, molybdenum, tungsten, mainly contributed positive MAFLD. Conclusion Our indicated that or cumulatively, Additional research needed validate findings longitudinal settings.

Language: Английский

Citations

28
A highly potential acyclic Schiff base fluorescent turn on sensor for Zn2+ ions and colorimetric chemosensor for Zn2+, Cu2+ and Co2+ ions and its applicability in live cell imaging DOI

Anjitha Jayaraj,

M Gayathri,

Gandhi Sivaraman

et al.

Journal of Photochemistry and Photobiology B Biology, Journal Year: 2021, Volume and Issue: 226, P. 112371 - 112371

Published: Dec. 2, 2021

Language: Английский

Citations

42
Outlining Potential Biomarkers of Exposure and Effect to Critical Minerals: Nutritionally Essential Trace Elements and the Rare Earth Elements DOI Creative Commons
Jill A. Jenkins, MaryLynn Musgrove, Sarah Jane O. White

et al.

Toxics, Journal Year: 2023, Volume and Issue: 11(2), P. 188 - 188

Published: Feb. 17, 2023

Emerging and low-carbon technologies innovations are driving a need for domestic sources, sustainable use, availability of critical minerals (CMs)—those vital to the national economic security United States. Understanding known potential health effects exposures such mineral commodities can inform prudent environmentally responsible handling harvesting. We review occurrence, predominant exposure pathways, adverse outcome pathways (AOP) human fish receptors those CMs that nutritionally essential trace metals (specifically, cobalt, chromium, manganese, nickel, zinc), as well rare earth elements. Biological responses some elements having comparable biogeochemistry sometimes be similar. Candidate quantifiable biomarkers assessing AOP conveyed.

Language: Английский

Citations

20
Evaluation of human health and ecological risk of heavy metals in water, sediment and shellfishes in typical artisanal oil mining areas of Nigeria DOI
Davies Ibienebo Chris, Amarachi Paschaline Onyena, Kabari Sam

et al.

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(33), P. 80055 - 80069

Published: June 8, 2023

Language: Английский

Citations

19