Association between lncRNAs with stem cells in cancer; a particular focus on lncRNA-CSCs axis in cancer immunopathogenesis DOI
Raed Obaid Saleh, Abdullah M. Shbeer, Raghu Jetti

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112306 - 112306

Published: June 3, 2024

Language: Английский

The acceleration of cisplatin resistance in colorectal cancer by lncRNA NORAD through regulation of miR-106a-5p/Cyclin D1 axis DOI
Liping Guo, Xianmei Li, Yujuan Kang

et al.

Journal of Chemotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Dec. 8, 2024

Colorectal cancer (CRC) is one of the leading causes cancer-related mortality. LncRNA NORAD frequently upregulated and positively associated with various progressions. We discovered was significantly in CRC tissues cells. sponged miR-106a-5p to form a ceRNA complex. MiR-106a-5p remarkedly downregulated tumors Silencing or overexpression effectively increased cisplatin sensitivity. In established resistant cell line, downregulated. Furthermore, we disclosed directly targeted 3'UTR CCND1, which an important cycle regulator overexpressed human cancers. Rescue experiments showed restoration CCND1 miR-106a-5p-overexpressing cells successfully recovered resistance. Finally, NORAD-overexpressing re-sensitized resistance by targeting CCND1. Summarily, this study uncovered NORAD-promoted through modulating miR-106a-5p-CCND1 axis, contributing developing novel therapy for treating chemoresistant CRC.

Language: Английский

Citations

1
Role of long noncoding RNAs in the regulation of alternative splicing in glioblastoma DOI

Bhupender Yadav,

Pooja Yadav, Sunita Yadav

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(10), P. 104140 - 104140

Published: Aug. 19, 2024

Language: Английский

Citations

0
Pyroptosis-Related Lncrna Prognostic Signatures for Cutaneous Melanoma and Tumor Microenvironment Status DOI
Huiling Deng, Yuxuan Chen, Ran An

et al.

Epigenomics, Journal Year: 2023, Volume and Issue: 15(12), P. 657 - 675

Published: June 1, 2023

Aims: To explore whether the expression of pyroptosis-related lncRNAs makes a difference in prognosis and antitumor immunity cutaneous melanoma (CM) patients. Methods: A series analyses were conducted to establish prognostic risk model validate its accuracy. Immune-related performed further assess associations among immune status, tumor microenvironment model. Results: Eight relevant ascertained applied The low-risk group had higher overall survival rate. Conclusion: established presents better prediction ability for CM patients provides new possible therapeutic targets CM.

Language: Английский

Citations

1
miRNAs as short non-coding RNAs in regulating doxorubicin resistance DOI
Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Farhad Adhami Moghadam

et al.

Journal of Cell Communication and Signaling, Journal Year: 2023, Volume and Issue: 17(4), P. 1181 - 1202

Published: Nov. 29, 2023

Language: Английский

Citations

1
Association between lncRNAs with stem cells in cancer; a particular focus on lncRNA-CSCs axis in cancer immunopathogenesis DOI
Raed Obaid Saleh, Abdullah M. Shbeer, Raghu Jetti

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112306 - 112306

Published: June 3, 2024

Language: Английский

Citations

0