Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 6, 2025
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, adaptability to tumor microenvironment (TME). This review explores diverse applications polymeric nanoparticles (NPs) in GBM treatment, including delivery chemotherapeutics, targeted therapeutics, immunotherapeutics, other agents for radiosensitization photodynamic therapy. Recent advances multifunctional polymer highlight their potential overcome challenges that brought, such heterogeneity tumor, BBB limitation, immunosuppressive TME, consideration biocompatibility safety. Meanwhile, future directions address these are also proposed. By addressing obstacles, polymer-based represents transformative strategy improving treatment outcomes, paving way more effective patient-specific therapies.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: April 4, 2024
Immunotherapy has been developed, which harnesses and enhances the innate powers of immune system to fight disease, particularly cancer. PD-1 (programmed death-1) PD-L1 death ligand-1) are key components in regulation system, context cancer immunotherapy. regulated by PTMs, including phosphorylation, ubiquitination, deubiquitination, acetylation, palmitoylation glycosylation. PROTACs (Proteolysis Targeting Chimeras) a type new drug design technology. They specifically engineered molecules that target specific proteins within cell for degradation. have designed demonstrated their inhibitory activity against PD-1/PD-L1 pathway, showed ability degrade proteins. In this review, we describe how improve efficacy could be novel strategy combine with radiotherapy, chemotherapy immunotherapy patients.
Language: Английский
Citations
6
Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)
Published: Feb. 1, 2025
ABSTRACT Gliomas are the most ordinary primary virulent brain tumours and commonly used clinical treatments include tumour resection, radiation therapy chemotherapy. Although significant progress has been made in recent years progression‐free survival (PFS) overall (OS) for patients with high‐grade gliomas, prognosis remains poor. Chemoresistance refers to phenomenon of decreased sensitivity cells drugs, resulting reduced or ineffective drug efficacy, is an important cause failure Exosomes, a type extracellular vesicle, secreted by cancer various stromal microenvironment (TME) transfer their inclusions cells, increasing chemoresistance. Furthermore, depletion exosomes reverses certain detrimental effects on metabolism restores chemotherapeutic agents. Here, we summarised correlation between resistance agents glioma patients, mechanisms action involved value. We aimed afford new thoughts research, diagnosis intervention chemoresistance patients.
Language: Английский
Citations
0
Cancer Science, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Neutrophils, as key components of the tumor microenvironment, play a crucial role in cancer progression and prognosis. This study aimed to identify neutrophil-related gene signature improve prognostic predictions explore potential immunotherapy targets for glioblastoma multiforme (GBM) patients. Through co-expression analysis, 60 neutrophil-associated genes were identified, showing significant enrichment 159 Gene Ontology terms eight KEGG pathways. Among these, 10 significantly associated with patient survival, leading development six-gene risk model termed Neutrophil-Related Prognostic Index (NRGPI). The NRGPI predicted overall survival (OS) both training validation cohorts (p < 0.05), enhanced accuracy when combined clinicopathological factors. Higher scores correlated worse OS, increased mortality, more aggressive disease progression. Immune profiling linked immune cell infiltration, checkpoint expression, mutation burden, suggesting its identifying candidates immunotherapy. identified genes, FN1 emerged central regulator, composition poor Pan-cancer analysis revealed consistent upregulation across types, underscoring broad clinical relevance. Additionally, tissue microarray using multiplex immunofluorescence on 84 GBM samples confirmed FN1, SDC1, TWIST1, higher levels reduced survival. These findings establish valuable biomarker GBM, offering novel insights into landscape positioning promising therapeutic target further investigation treatment.
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Aug. 19, 2024
SUMOylation, a post-translational modification involving the covalent attachment of small ubiquitin-like modifier (SUMO) proteins to target substrates, plays pivotal role at intersection gut health and disease, influencing various aspects intestinal physiology pathology. This review provides comprehensive examination SUMOylation's diverse roles within microenvironment. We examine its critical in maintaining epithelial barrier integrity, regulating immune responses, mediating host-microbe interactions, thereby highlighting complex molecular mechanisms that underpin homeostasis. Furthermore, we explore impact SUMOylation dysregulation disorders, including inflammatory bowel diseases colorectal cancer, implications as potential diagnostic biomarker therapeutic target. By integrating current research findings, this offers valuable insights into dynamic interplay between health, paving way for novel strategies aimed restoring equilibrium combating associated pathologies.
Language: Английский
Citations
3
Bioengineering, Journal Year: 2024, Volume and Issue: 12(1), P. 26 - 26
Published: Dec. 31, 2024
Post-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including modifications on side chains and peptide backbones. Many PTMs profoundly impact cellular molecular functions structures, their significance extends evolutionary studies as well. In light of these implications, we have explored how artificial intelligence (AI) can be utilized in researching PTMs. Initially, rationales for adopting AI its advantages understanding the discussed. Then, various deep learning architectures programs, recent applications language models, predicting PTM sites proteins regulatory compared. Finally, our high-throughput PTM-data-generation pipeline, which formats data suitably training predictions is described. We hope this review illuminates areas where future models improved, thereby contributing field bioengineering.
Language: Английский
Citations
1
Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Citations
0