Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 31, 2024

Abstract Cancer neuroscience is an emerging field that investigates the intricate relationship between nervous system and cancer, gaining increasing recognition for its importance. The central governs development of directly affects brain tumors, peripheral (PNS) shapes tumor microenvironment (TME) tumors. Both systems are crucial in cancer initiation progression, with recent studies revealing a more role PNS within TME. Tumors not only invade nerves but also persuade them through remodeling to further promote malignancy, creating bidirectional interaction cancers. Notably, immune cells contribute this communication, forming triangular influences protumor inflammation effectiveness immunotherapy. This review delves into mechanisms connecting focusing on how various cell types influence nerve‒tumor interactions, emphasizing clinical relevance nerve‒immune dynamics. By deepening our understanding interplay nerves, cells, has potential reshape biology insights, inspire innovative therapies, improve outcomes patients.

Language: Английский

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Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated poor prognosis CRC, impact of nerve density diameter on behavior remains unclear. This study aims to evaluate prognostic value characteristics CRC verify nerves growth. Tissue samples from 129 patients were stained immunofluorescent markers NF-L S100B detect nerves. Nerve measured normalized. Kaplan-Meier survival analysis Cox regression models used identify factors. Prognostic established using receiver operating characteristic (ROC) curve assess predictive A murine chemical denervation model was employed disrupt sympathetic 6-hydroxydopamine, inhibit muscarinic receptor 3 darifenacin, ablate sensory neurons capsaicin. total 0.72 ± 0.59/mm², intratumoral (0.42 0.40/mm²) being significantly lower than extratumoral regions (1.00 0.75/mm²). average 28.14 6.04 μm, no difference between (28.2 7.65 μm) (27.86 6.72 μm). PNI observed 65 (50.4%). high normalized (NND) shorter overall disease-free patients, identified as an independent factor. Patients exhibit higher NND. Incorporating NND into ROC improved sensitivity specificity predictions. In model, sympathetic, parasympathetic, reduced rectal volume. critical factors influencing patient enhance accuracy prediction models. Moreover, effectively inhibits growth vivo, highlighting potential targeting therapeutic strategy CRC.

Language: Английский

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Neural-cancer Crosstalk: Reciprocal Molecular Circuits Driving Gastric Tumorigenesis and Emerging Therapeutic Opportunities

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217589 - 217589

Published: Feb. 1, 2025

Language: Английский

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Nervous system in colorectal cancer

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217431 - 217431

Published: Dec. 1, 2024

Language: Английский

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