Effects of the Interaction Between Oxidative Balance Score and Polygenic Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean Adults DOI Creative Commons

Minyeong Kim,

Dayeon Shin

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1556 - 1556

Published: Dec. 18, 2024

Oxidative stress is implicated in insulin resistance, obesity, and metabolic syndromes (MetSs). However, the interplay between oxidative genetic predisposition during development of MetS remains unclear. In this study, we aimed to investigate effects interaction balance score (OBS) polygenic risk (PRS) on incidence middle-aged Korean adults. We analyzed data from 25,879 participants aged ≥40 years Health Examinees Cohort Genome Epidemiology Study. The OBS was calculated using 11 antioxidant five pro-oxidant factors. A genome-wide association study clumping analysis identified 16 independent single-nucleotide polymorphisms associated with that were used calculate individual PRSs. Multivariable Cox proportional hazard models adjusted for confounding variables assess impact PRS MetS. During a mean follow-up period 4.3 years, recorded 3153 cases both men women, group lowest high had 1.50-fold (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.07–2.11) 1.89-fold (HR 1.89, CI 1.40–2.56) higher incidence, respectively, compared those highest low PRS. Among women PRS, HRs decreased significantly across quintiles 1 through 5 (p trend = 0.009). These findings suggest managing may be particularly crucial individuals

Language: Английский

Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation DOI
Jeong‐Hoon Jang,

Do-Hee Kim,

Kyung‐Soo Chun

et al.

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Zinc phthalocyanine and sulfasalazine coloaded nanoaggregates with Prussian blue functionalization for sensitizing tumor photothermal/photodynamic therapy DOI

Qinxin Wang,

Feifei Wu,

Xiaonan Qiu

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 685, P. 509 - 521

Published: Jan. 14, 2025

Language: Английский

Citations

0
Methyl 3-Bromo-4,5-dihydroxybenzoate Attenuates Inflammatory Bowel Disease by Regulating TLR/NF-κB Pathways DOI Creative Commons
Jing Huang, Lei Li,

Liyan Xu

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(1), P. 47 - 47

Published: Jan. 19, 2025

Inflammatory bowel disease (IBD) is characterized by uncontrolled, chronic relapsing inflammation in the gastrointestinal tract and has become a global healthcare problem. Here, we aimed to illustrate anti-inflammatory activity underlying mechanism of methyl 3-bromo-4,5-dihydroxybenzoate (MBD), compound derived from marine organisms, especially IBD, using zebrafish model. The results indicated that MBD could inhibit inflammatory responses induced CuSO4, tail amputation LPS zebrafish. Furthermore, notably inhibited intestinal migration immune cells, enhanced integrity gut mucosal barrier improved peristalsis function IBD model trinitro-benzene-sulfonic acid (TNBS). In addition, ROS elevation TNBS. Network pharmacology analysis, molecular docking, transcriptomics sequencing RT-PCR were conducted investigate potential mechanism. showed regulate TLR/NF-κB pathways inhibiting mRNA expression TNF-α, NF-κB, IL-1, IL-1β, IL6, AP1, IFNγ, IKKβ, MyD88, STAT3, TRAF1, TRAF6, NLRP3, NOD2, TLR3 TLR4, promoting IL4, IκBα Bcl-2. conclusion, these findings indicate be candidate for treatment IBD.

Language: Английский

Citations

0
Molecular Insights in the Anticancer Activity of Natural Tocotrienols: Targeting Mitochondrial Metabolism and Cellular Redox Homeostasis DOI Creative Commons
Raffaella Chiaramonte,

Giulia Sauro,

Domenica Giannandrea

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 115 - 115

Published: Jan. 20, 2025

The role of mitochondria as the electric engine cells is well established. Over past two decades, accumulating evidence has pointed out that, despite presence a highly active glycolytic pathway (Warburg effect), functional and even upregulated mitochondrial respiration occurs in cancer to meet need high energy biosynthetic demand sustain their anabolic growth. Mitochondria are also primary source intracellular ROS. Cancer maintain moderate levels ROS promote tumorigenesis, metastasis, drug resistance; indeed, once cytotoxicity threshold exceeded, trigger oxidative damage, ultimately leading cell death. Based on this, metabolic functions generation considered attractive targets synthetic natural anticancer compounds. Tocotrienols (TTs), specifically δ- γ-TT isoforms, vitamin E-derived biomolecules widely shown possess striking properties since they regulate several molecular pathways. Herein, we provide for first time an overview reprogramming redox homeostasis perturbation occurring cells, highlighting involvement TTs. This sheds light use these compounds promising preventive or therapeutic approach novel strategies.

Language: Английский

Citations

0
-EGCG Inhibits Tobacco Smoke-Promoted Proliferation of Lung Cancer Cells Through Targeting CCL5 DOI

Zhiyuan Dong,

Jin‐Yi Wu,

Liping He

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156512 - 156512

Published: Feb. 15, 2025

Language: Английский

Citations

0
Oxidative Stress and Redox Signaling in Gastric Cancer: From Mechanisms to Therapeutic Implications DOI Creative Commons
Zehua Chen,

Jiawu Fan,

Xiao‐Long Chen

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 258 - 258

Published: Feb. 24, 2025

Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.

Language: Английский

Citations

0
Faberidilactone A, a Sesquiterpene Dimer, Inhibits Hepatocellular Carcinoma Progression Through Apoptosis, Ferroptosis, and Anti-Metastatic Mechanisms DOI Creative Commons

Ruyu Cao,

Yuhui Liu, Jiahe Bao

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1095 - 1095

Published: Feb. 27, 2025

Cancer remains a significant global public health challenge, with hepatocellular carcinoma (HCC) ranking among the top five malignancies in terms of mortality. Faberidilactone A, sesquiterpenoid dimer isolated from Inula japonica, exhibits potent cytotoxicity against various human tumor cell lines and demonstrates remarkable antitumor potential. In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis ferroptosis, causes cycle arrest, enhances production intracellular reactive oxygen species (ROS), disrupts mitochondrial function. Mechanistic investigations via Western blot analysis indicated impedes proliferation by modulating signal transducer activator transcription 3 (STAT3) signaling pathway inhibits metastasis affecting focal adhesion kinase (FAK) pathway. vivo experiments zebrafish model demonstrated effectively suppresses dissemination anti-angiogenic properties. When concentration reached 10 µM, inhibition rates proliferation, migration, intersegmental vessels (ISVs) length were 76.9%, 72.6%, 46.2%, respectively. These findings underscore therapeutic potential as promising agent for HCC treatment.

Language: Английский

Citations

0
Divergent impact of endotoxin priming and endotoxin tolerance on macrophage responses to Cancer cells DOI
Konkonika Roy, Tomasz Jędrzejewski, Justyna Sobocińska

et al.

Cellular Immunology, Journal Year: 2025, Volume and Issue: 411-412, P. 104934 - 104934

Published: March 1, 2025

Language: Английский

Citations

0
Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR DOI

Ji Zhou,

Qing Shu,

Tian Wang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177478 - 177478

Published: March 1, 2025

Language: Английский

Citations

0
Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication DOI Creative Commons

Jingyu Xu,

B Wang,

Haiqing Ao

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission humoral regulation. Due widespread expression of receptors (GR), effects CORT are almost ubiquitous in various tissue cells. Therefore, on one hand, is molecular signal activates body’s system during other due chemical properties GCs, anti-inflammatory act as stabilizers control response stress. Inflammation manifestation activation. plays dual roles this process both promoting inflammation exerting As hormone, levels fluctuate with degree duration stress, determining its changes it induces. essential for resist diseases maintain homeostasis, imbalance being key factor development diseases. understanding role mechanisms action immunity crucial. This review addresses important issue summarizes interactions between system.

Language: Английский

Citations

0