Overview of Wnt/β-Catenin Pathway and DNA Damage/Repair in Cancer
Biology,
Journal Year:
2025,
Volume and Issue:
14(2), P. 185 - 185
Published: Feb. 11, 2025
The
Wnt/β-catenin
pathway
takes
part
in
important
cellular
processes
tumor
cells,
such
as
gene
expression,
adhesion,
and
survival.
canonical
is
activated
several
tumors,
β-catenin
its
major
effector.
union
of
Wnt
to
the
co-receptor
complex
causes
inhibition
GSK3β
activity,
thus
preventing
phosphorylation
degradation
β-catenin,
which
accumulates
cytoplasm,
subsequently
be
transported
nucleus
associate
with
transcription
factors.
relationship
between
DNA
damage/repair
mechanisms
has
been
a
focus
for
last
few
years.
Studying
network
interactions
proteins
become
successful
research
field.
This
review
provides
an
overview
participation
their
future
implications
targets
cancer
therapy.
Language: Английский
Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway
Jian Zhong Huo,
No information about this author
Kun Nie,
No information about this author
Tianfeng Yang
No information about this author
et al.
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119820 - 119820
Published: April 1, 2025
Language: Английский
Targeting pediatric adrenocortical carcinoma: Molecular insights and emerging therapeutic strategies
Cancer Treatment Reviews,
Journal Year:
2025,
Volume and Issue:
136, P. 102942 - 102942
Published: April 17, 2025
Language: Английский
Wnt-Regulated Therapeutics for Blood-Brain Barrier Modulation and Cancer Therapy
Pei An,
No information about this author
Yang Tong,
No information about this author
Rui Mu
No information about this author
et al.
Bioconjugate Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
The
Wnt
signaling
pathway
has
a
significant
regulatory
part
in
tissue
development
and
homeostasis.
Dysregulation
of
the
been
associated
with
many
diseases
including
cancers
various
brain
diseases,
making
this
promising
therapeutic
target
for
these
diseases.
In
review,
we
describe
roles
blood-brain
barrier
(BBB)
intracranial
tumors
peripheral
tumors,
from
preclinical
clinical
perspectives,
introduce
Wnt-regulated
therapeutics
types
drugs
nanomedicines
as
BBB
modulators
brain-oriented
drug
delivery
cancer
treatments,
finally
discuss
limitations
future
perspectives
therapeutics.
Language: Английский