Identification of PTPN1 as the anticancer target of resveratrol against Epstein-Barr virus-associated cancers DOI Creative Commons
Na Liu, Yueshuo Li, Min Tang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background Epstein-Barr virus (EBV) is a well-known oncogenic virus, which plays pivotal role in cancer chemotherapy resistance. Resveratrol has been shown to exert significant cytotoxic effects on cells and enhances sensitivity. Nevertheless, the extensive therapeutic targets underlying mechanisms are not well-established. Methods The efficacy of resveratrol was assessed through cellular experiments nude mice EBV-positive nasopharyngeal carcinoma gastric cells. prediction resveratrol’ s target genes involved application chemical similarity searches molecular docking techniques. Expression data these genes, along with clinical from tumor patients, were obtained GEO database TCGA database. predictive value models evaluated using Kaplan-Meier survival. Univariate multivariate Cox regression analyses used examine relationship between gene prognosis. Results We observed that can significantly inhibit cell viability tumorigenicity To investigate mechanisms, we pursued study by employing combination search results suggest may hone PTPN1 as target. PTPN1, recognized non-receptor protein tyrosine phosphatase, an emerging oncogene, highly expressed proved engages decreases stability PTPN1. Furthermore, enhance cytotoxicity cisplatin Conclusions Overall, our findings illuminate anti-cancer effect targeting propose merits additional investigation potential agent for therapy.

Language: Английский

Identification of PTPN1 as the anticancer target of resveratrol against Epstein-Barr virus-associated cancers DOI Creative Commons
Na Liu, Yueshuo Li, Min Tang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background Epstein-Barr virus (EBV) is a well-known oncogenic virus, which plays pivotal role in cancer chemotherapy resistance. Resveratrol has been shown to exert significant cytotoxic effects on cells and enhances sensitivity. Nevertheless, the extensive therapeutic targets underlying mechanisms are not well-established. Methods The efficacy of resveratrol was assessed through cellular experiments nude mice EBV-positive nasopharyngeal carcinoma gastric cells. prediction resveratrol’ s target genes involved application chemical similarity searches molecular docking techniques. Expression data these genes, along with clinical from tumor patients, were obtained GEO database TCGA database. predictive value models evaluated using Kaplan-Meier survival. Univariate multivariate Cox regression analyses used examine relationship between gene prognosis. Results We observed that can significantly inhibit cell viability tumorigenicity To investigate mechanisms, we pursued study by employing combination search results suggest may hone PTPN1 as target. PTPN1, recognized non-receptor protein tyrosine phosphatase, an emerging oncogene, highly expressed proved engages decreases stability PTPN1. Furthermore, enhance cytotoxicity cisplatin Conclusions Overall, our findings illuminate anti-cancer effect targeting propose merits additional investigation potential agent for therapy.

Language: Английский

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