Gut Microbiota is Altered in Patients with Alzheimer’s Disease

Journal of Alzheimer s Disease, Journal Year: 2018, Volume and Issue: 63(4), P. 1337 - 1346

Published: May 11, 2018

Previous studies suggest that gut microbiota is associated with neuropsychiatric disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, and depression. However, whether the composition diversity of altered in patients Alzheimer's disease (AD) remains large ly unknown. In present study, we collected fecal samples from 43 AD age- gender-matched cognitively normal controls. 16S ribosomal RNA sequencing technique was used to analyze feces. The different between two groups. Several bacteria taxa were those controls at taxonomic levels, Bacteroides, Actinobacteria, Ruminococcus, Lachnospiraceae, Selenomonadales. Our findings may be involved pathogenesis AD.

Language: Английский

---

The gut microbiota in anxiety and depression – A systematic review

Clinical Psychology Review, Journal Year: 2020, Volume and Issue: 83, P. 101943 - 101943

Published: Oct. 29, 2020

Language: Английский

---

Regulation of inflammation by microbiota interactions with the host

Nature Immunology, Journal Year: 2017, Volume and Issue: 18(8), P. 851 - 860

Published: July 19, 2017

Language: Английский

---

Pathways linking biodiversity to human health: A conceptual framework

Environment International, Journal Year: 2021, Volume and Issue: 150, P. 106420 - 106420

Published: Feb. 7, 2021

Biodiversity is a cornerstone of human health and well-being. However, while evidence the contributions nature to rapidly building, research into how biodiversity relates remains limited in important respects. In particular, better mechanistic understanding range pathways through which can influence needed. These relate both psychological social processes as well biophysical processes. Building on from across natural, sciences, we present conceptual framework organizing linking health. Four domains pathways—both beneficial harmful—link with health: (i) reducing harm (e.g. provision medicines, decreasing exposure air noise pollution); (ii) restoring capacities attention restoration, stress reduction); (iii) building promoting physical activity, transcendent experiences); (iv) causing dangerous wildlife, zoonotic diseases, allergens). We discuss test components biodiversity-health available analytical approaches existing datasets. world accelerating declines biodiversity, profound land-use change, an increase non-communicable diseases globally, greater these reinforce conservation strategy for promotion people nature. conclude by identifying avenues recommendations policy practice foster biodiversity-focused public actions.

Language: Английский

---

Recognizing Depression from the Microbiota–Gut–Brain Axis

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(6), P. 1592 - 1592

Published: May 29, 2018

Major depression is one of the leading causes disability, morbidity, and mortality worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction brain, immune system, endocrine gut. Traditional treatments all target with different drugs and/or psychotherapy. Unfortunately, most patients have never received any treatment. Studies indicate that gut microbiota could be direct cause for disorder. Abnormal microbiota–gut–brain may mental disorders, while correcting these disturbance alleviate depression. Nowadays, modulation has become hot topic in treatment research disorders. Depression closely related health condition axis, maintaining/restoring normal helps prevention/therapy

Language: Английский

---

Gut microbiota and major depressive disorder: A systematic review and meta-analysis

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 266, P. 1 - 13

Published: Jan. 24, 2020

Language: Английский

---

Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Frontiers in Public Health, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 24, 2020

The exponential growth of pollutant discharges into the environment due to increasing industrial and agricultural activities is a rising threat for human health biggest concern environmental globally. Several synthetic chemicals, categorized as potential endocrine-disrupting chemicals (EDCs), are evident affect not only livestock wildlife but also humankind. In recent years, exposure EDCs has received increased awareness their association with altered documented by several epidemiological experimental studies. associated deleterious effects on male female reproductive health; causes diabetes, obesity, metabolic disorders, thyroid homeostasis increase risk hormone-sensitive cancers. Sewage effluents major source EDCs, which eventually reach large water bodies potentially contaminate drinking supply. Similarly, storage material such different types plastics leaches out in Water. Domestic wastewater containing pharmaceutical ingredients, metals, pesticides personal care product additives influences endocrine activity. These act via various receptors through variety known unknown mechanisms including epigenetic modification. They differ from classic toxins ways low-dose effect, non-monotonic dose trans-generational effects. This review aims highlight hidden burden discusses non-classical toxic properties an attempt understand magnitude exposome health. Present data advocate that there may be associations between undesirable outcomes warrants further bio-monitoring EDCs.

Language: Английский

---

Reduced microbiome alpha diversity in young patients with ADHD

PLoS ONE, Journal Year: 2018, Volume and Issue: 13(7), P. e0200728 - e0200728

Published: July 12, 2018

ADHD is a psychiatric disorder which characterized by hyperactivity, impulsivity and attention problems. Due to recent findings of microbial involvement in other disorders like autism depression, role the gut microbiota pathogenesis assumed but has not yet been investigated. In this study, 14 male patients (mean age: 11.9 yrs.) 17 controls 13.1 was examined via next generation sequencing 16S rDNA analyzed for diversity biomarkers. We found that (alpha diversity) significantly decreased compared (pShannon = 0.036) composition (beta differed between (pANOSIM 0.033, pADONIS 0.006, pbetadisper 0.002). detail, bacterial family Prevotellacae associated with controls, while showed elevated levels Bacteroidaceae, both Neisseriaceae Neisseria spec. were as possible biomarkers juvenile ADHD. Our results point link certain ADHD, being very promising ADHD-associated candidate. This finding provides basis systematic, longitudinal assessment microbiome yielding potential prevention therapeutic intervention.

Language: Английский

---

Gut-Brain Psychology: Rethinking Psychology From the Microbiota–Gut–Brain Axis

Frontiers in Integrative Neuroscience, Journal Year: 2018, Volume and Issue: 12

Published: Sept. 11, 2018

Mental disorders and neurological diseases have brought rapidly increasing medical burdens. Although extensive researches been conducted hugely, effective therapies still progressing slowly. Current dilemma reminds us that the human is a superorganism. Only if we take self its partner microbiota into consideration at same time can better understand these diseases. Over last few centuries, has experienced tremendous changes much more than own genes because of modern transformations in diet, lifestyle, care, so on, paralleling epidemiological transition. Existing research indicates gut plays an important role this According to gut–brain psychology, crucial part gut–brain, it communicates with brain via microbiota–gut–brain axis. The almost develops synchronously brain, mind. Gut influences various normal mental processes phenomena they are involved pathophysiology numerous Targeting therapy for promising approach supported by three theories: hypothesis, "old friend" leaky theory. effects behavior fulfilled through microbiota-gut-brain axis which mainly composed nervous pathway, endocrine immune pathway. Undoubtedly, psychology will bring great enhancement neuroscience, psychiatry. Various improving methods including FMT, probiotics, prebiotics, healthy lifestyle shown capability promote function brain. Harnessing improve health, prevent related be true future.

Language: Английский

---

The Role of Microbiome in Insomnia, Circadian Disturbance and Depression

Frontiers in Psychiatry, Journal Year: 2018, Volume and Issue: 9

Published: Dec. 5, 2018

Good sleep and mood are important for health keeping active. Numerous studies have suggested that the incidence of insomnia depressive disorder linked to biological rhythms, immune function nutrient metabolism, but exact mechanism is not yet clear. There considerable evidence showing gut microbiome only affects digestive, metabolic, functions host also regulates mental states through microbiome-gut-brain axis. Preliminary indicates microorganisms circadian genes can interact with each other. The characteristics gastrointestinal metabolism related host's rhythm. Moreover, emotion physiological stress affect composition microorganisms. inflammation may be loss, misalignment, affective disorders metabolic disease. In this review article, we discuss various how its activities rhythms emotions host. Exploring effects on depression will help further our understanding pathogenesis disorders. It therefore regulate maintain a normal micro-ecological environment in patients when treating

Language: Английский

---