Neuronal regulation of the gut immune system and neuromodulation for treating inflammatory bowel disease DOI Creative Commons
Luis C. Populin, Martin J. Stebbing, John B. Furness

et al.

FASEB BioAdvances, Journal Year: 2021, Volume and Issue: 3(11), P. 953 - 966

Published: Aug. 14, 2021

The gut immune system in the healthy intestine is anti-inflammatory, but can move to a pro-inflammatory state when challenged by pathogens or disease. nervous influences level of inflammation through enteric neurons and extrinsic neural connections, particularly vagal sympathetic innervation gastrointestinal tract, each which exerts anti-inflammatory effects. Within (ENS), three neuron types that influence cells have been identified, intrinsic primary afferent (IPANs), vasoactive intestinal peptide (VIP) project mucosa, cholinergic macrophages external muscle layers. neuropeptides, calcitonin gene-related (CGRP), tachykinins, neuromedin U (NMU), are contained IPANs, VIP produced mucosa innervating neurons, all cells, notably innate lymphoid (ILCs). ILC2 stimulated release IL-22, promotes microbial defense tissue repair. Enteric innervated vagus, and, large intestine, pelvic nerves. Vagal nerve stimulation reduces inflammation, may be both efferent (motor) pathways ENS, connect integrating centers CNS. Efferent from CNS their effects either pathways. final reduce action noradrenaline on β2 adrenergic receptors expressed cells. Activation an attractive option treat inflammatory bowel disease refractory other treatments. Further investigation ways reflexes, integrate modulate needed optimize neuromodulation therapy.

Language: Английский

Somatotopic Organization and Intensity Dependence in Driving Distinct NPY-Expressing Sympathetic Pathways by Electroacupuncture DOI Creative Commons
Shenbin Liu, Zhifu Wang,

Yang‐Shuai Su

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(3), P. 436 - 450.e7

Published: Aug. 12, 2020

Language: Английский

Citations

271
The microbiome-gut-brain axis in acute and chronic brain diseases DOI Creative Commons
Corinne Benakis, Camille Martin‐Gallausiaux, Jean‐Pierre Trezzi

et al.

Current Opinion in Neurobiology, Journal Year: 2019, Volume and Issue: 61, P. 1 - 9

Published: Dec. 6, 2019

The gut microbiome — the largest reservoir of microorganisms human body is emerging as an important player in neurodevelopment and ageing well brain diseases including stroke, Alzheimer's disease Parkinson's disease. growing knowledge on mediators triggered pathways has advanced our understanding interactions along gut-brain axis. Gut bacteria produce neuroactive compounds can modulate neuronal function, plasticity behavior. Furthermore, intestinal impact host's metabolism immune status which turn affect enteric central nervous systems. Here, we discuss recent insights from studies animal models bi-directional communication microbiome-gut-brain axis both acute chronic diseases.

Language: Английский

Citations

156
Somatosensory and autonomic neuronal regulation of the immune response DOI

Swalpa Udit,

Kimbria J. Blake,

Isaac M. Chiu

et al.

Nature reviews. Neuroscience, Journal Year: 2022, Volume and Issue: 23(3), P. 157 - 171

Published: Jan. 7, 2022

Language: Английский

Citations

134
Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms DOI
Yue Wang,

Gaofeng Zhan,

Ziwen Cai

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 127, P. 37 - 53

Published: April 21, 2021

Language: Английский

Citations

129
Therapeutic Potential of Vagus Nerve Stimulation for Inflammatory Bowel Diseases DOI Creative Commons
Bruno Bonaz,

Valérie Sinniger,

Sonia Pellissier

et al.

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: March 22, 2021

The vagus nerve is a mixed nerve, comprising 80% afferent fibers and 20% efferent fibers. It allows bidirectional communication between the central nervous system digestive tract. has dual anti-inflammatory properties via activation of hypothalamic pituitary adrenal axis, by its afferents, but also through vago-vagal inflammatory reflex involving an (vagal) arm, called cholinergic pathway. Indeed, release acetylcholine at end able to inhibit tumor necrosis factor (TNF) alpha macrophages interneuron enteric synapsing vagal endings releasing acetylcholine. synapses with splenic sympathetic TNF-alpha macrophages. can activate spinal after integration afferents. This anti-TNF-alpha effect be used in treatment chronic bowel diseases, represented Crohn's disease ulcerative colitis where this cytokine plays key role. Bioelectronic medicine, stimulation, may have interest non-drug therapeutic approach as alternative conventional drugs, which are not devoid side effects feared patients.

Language: Английский

Citations

114
A 12‐month pilot study outcomes of vagus nerve stimulation in Crohn's disease DOI

Valérie Sinniger,

Sonia Pellissier, Florence Fauvelle

et al.

Neurogastroenterology & Motility, Journal Year: 2020, Volume and Issue: 32(10)

Published: June 8, 2020

Abstract Background The vagus nerve has anti‐inflammatory properties. We aimed to investigate stimulation (VNS) as a new therapeutic strategy targeting an intrinsic pathway in pilot study Crohn's disease patients. main objectives addressed the questions of long‐term safety, tolerability, and effects this therapy. This is continuation previous reported findings at 6 months. Methods Nine patients with moderate active underwent VNS. An electrode wrapped around left cervical was continuously stimulated over 1 year. Clinical, biological, endoscopic parameters, cytokines (plasma, gut), mucosal metabolites were followed‐up. Key Results After year VNS, five clinical remission six remission. C‐reactive protein (CRP) fecal calprotectin decreased patients, respectively. Seven restored their vagal tone digestive pain score. patients' cytokinergic profile evolved toward more “healthy profile”: Interleukins 6, 23, 12, tumor necrosis factor α, transforming growth factorβ1 most impacted cytokines. Correlations observed between CRP some gut mucosa taurine, lactate, alanine, beta‐hydroxybutyrate. VNS well tolerated. Conclusion & Inferences Vagus appears innovative well‐tolerated treatment disease. 12 months, homeostatic reduced inflammatory state probably global modulatory effect on immune system along metabolic regulations. needs replication larger randomized double‐blinded control study.

Language: Английский

Citations

134
Crosstalk between the nervous system and the kidney DOI Creative Commons
Shinji Tanaka, Mark D. Okusa

Kidney International, Journal Year: 2019, Volume and Issue: 97(3), P. 466 - 476

Published: Nov. 22, 2019

Language: Английский

Citations

103
Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury DOI Open Access
Shinji Tanaka, Chikara Abe, Stephen B. G. Abbott

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(12)

Published: March 18, 2021

Significance The ability of vagus nerve stimulation to generate anti-inflammatory and tissue-protective effects has been known for some time. We have made use cutting-edge tools precisely map the neural circuits that contribute beneficial stimulation. Stimulation was specifically restricted either afferent or efferent neurons in by genetically programming appropriate cells express a light-sensitive cation channel. show that, while both signals provide protection from kidney injury, generates sympathetic response protects mice absence signals. This provides an insight into pathways neuroimmune potential therapeutics.

Language: Английский

Citations

90
Restoration of dysbiotic human gut microbiome for homeostasis DOI
Kunal Dixit, Diptaraj Chaudhari, Dhiraj Dhotre

et al.

Life Sciences, Journal Year: 2021, Volume and Issue: 278, P. 119622 - 119622

Published: May 17, 2021

Language: Английский

Citations

72
Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage DOI Open Access

Chang-Zhang Chai,

Ue-Cheung Ho, Lu‐Ting Kuo

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10943 - 10943

Published: June 30, 2023

Aneurysmal subarachnoid hemorrhage (aSAH) is one of the most severe neurological disorders, with a high mortality rate and disabling functional sequelae. Systemic inflammation following hemorrhagic stroke may play an important role in mediating intracranial extracranial tissue damage. Previous studies showed that various systemic inflammatory biomarkers might be useful predicting clinical outcomes. Anti-inflammatory treatment promising therapeutic approach for improving prognosis patients aSAH. This review summarizes complicated interactions between nervous system immune system.

Language: Английский

Citations

27