Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(3)
Published: March 1, 2025
ABSTRACT
Patients
are
usually
highly
stressed
during
the
immediate
perioperative
period.
It
remains
unclear
whether
increased
stress
contributes
to
postoperative
brain
dysfunction.
Here,
clinical
setting
was
mimicked
via
exploratory
laparotomy
and
restraint
stress.
The
response
assessed
by
measuring
levels
of
hormones
IL‐6
in
peripheral
blood.
Behaviors
were
evaluated
with
open
field,
novel
object
recognition,
Barnes
maze
tests.
We
found
that
surgical
non‐surgery‐related
synergistically
trigger
meningeal
CD8
+
T
cell
accumulation,
dysfunction,
hormone
blood
adult
mice,
but
simple
or
had
no
significant
effect
on
these
parameters.
Limiting
accumulation
an
anti‐CD8
antibody
alleviated
impact
surgery
plus
function,
neuroinflammation,
neurogenesis.
partial
elimination
microglia
before
cognitive
decreased
hippocampal
chemotactic
factor
levels.
Our
findings
indicate
synergistic
dysfunction
triggering
suggesting
potential
limiting
as
a
preventive
method
for
image
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: March 3, 2025
Background
Colorectal
adenomas,
which
are
precancerous
lesions
that
can
develop
into
colorectal
cancer,
present
a
significant
challenge
due
to
the
lack
of
comprehensive
early
screening
and
clear
identification
risk
factors.
Objectives
We
conduct
double-blind,
prospective
cross-sectional
analysis
examine
relationship
between
lifestyle,
mental
health,
adenomas.
Methods
Between
June
2023
July
2024,
we
surveyed
246
participants
at
Hubei
Provincial
Hospital
Traditional
Chinese
Medicine
in
Wuhan
using
self-administered
online
questionnaire.
Results
The
majority
were
over
age
50
(49.6%),
married
or
living
with
partner
(87.08%),
employed
as
office
workers
technicians
(44.3%).
Among
total
population,
435
individuals
(53.5%)
diagnosed
A
positive
association
was
observed
being
manager
(OR
=
2.340;
95%
CI
1.043–5.248)
presence
well
having
BMI
28
6.000;
1.501–23.991).
After
adjusting
for
professional
role
BMI,
no
associations
found
scores
on
HADS-D
(AOR
1.031;
0.967–1.099)
PSS-10
0.971;
0.923–1.022)
scales
However,
higher
AUDIT
1.001–1.144),
CDS-12
1.028;
1.003–1.054),
PSQI
1.079;
1.003–1.161),
HADS-A
1.156;
1.059–1.262)
significantly
associated
an
increased
likelihood
Conclusion
study
highlights
significance
addressing
alcohol
consumption,
smoking,
sleep
quality,
anxiety
reduce
Targeted
health
interventions
may
play
crucial
alleviating
this
burden
enhancing
overall
population
health.
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(3)
Published: March 1, 2025
ABSTRACT
Patients
are
usually
highly
stressed
during
the
immediate
perioperative
period.
It
remains
unclear
whether
increased
stress
contributes
to
postoperative
brain
dysfunction.
Here,
clinical
setting
was
mimicked
via
exploratory
laparotomy
and
restraint
stress.
The
response
assessed
by
measuring
levels
of
hormones
IL‐6
in
peripheral
blood.
Behaviors
were
evaluated
with
open
field,
novel
object
recognition,
Barnes
maze
tests.
We
found
that
surgical
non‐surgery‐related
synergistically
trigger
meningeal
CD8
+
T
cell
accumulation,
dysfunction,
hormone
blood
adult
mice,
but
simple
or
had
no
significant
effect
on
these
parameters.
Limiting
accumulation
an
anti‐CD8
antibody
alleviated
impact
surgery
plus
function,
neuroinflammation,
neurogenesis.
partial
elimination
microglia
before
cognitive
decreased
hippocampal
chemotactic
factor
levels.
Our
findings
indicate
synergistic
dysfunction
triggering
suggesting
potential
limiting
as
a
preventive
method
for
image
