Effects of miR-722 on gene expression and alternative splicing in the liver of half-smooth tongue sole after infection with Vibrio anguillarum DOI
Hongning Liu, Suxu Tan,

Sen Han

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 144, P. 109275 - 109275

Published: Dec. 9, 2023

Language: Английский

Protective effects of paeonol against cognitive impairment in lung diseases DOI Creative Commons
Yen-Chang Chen,

Jia-Hong Chen,

Cheng‐Fang Tsai

et al.

Journal of Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 155(3), P. 101 - 112

Published: May 5, 2024

Pulmonary inflammation may lead to neuroinflammation resulting in neurological dysfunction, and it is associated with a variety of acute chronic lung diseases. Paeonol an herbal phenolic compound anti-inflammatory anti-oxidative properties. The aim this study understand the beneficial effects paeonol on cognitive impairment, pulmonary its underlying mechanisms. inflammation-associated deficit was observed TNFα-stimulated mice, mitigated impairment by reducing expressions interleukin (IL)-1β, IL-6, NOD-like receptor family pyrin domain-containing 3 (NLRP3) hippocampus. Moreover, elevated plasma miR-34c-5p lung-inflammed mice also reduced paeonol. induced intratracheal instillation TNFα resulted immune cells infiltration bronchoalveolar lavage fluid, edema, fibrosis, these inflammatory responses were alleviated orally. In MH-S alveolar macrophages, tumor necrosis factor (TNF) α- phorbol myristate acetate (PMA)-induced inflammasome activation ameliorated addition, antioxidants paeonol, reactive oxygen species production reduced. study, demonstrates protective against deficits exerting properties, suggesting powerful benefit as potential therapeutic agent.

Language: Английский

Citations

1
The role of the peripheral system dysfunction in the pathogenesis of sepsis-associated encephalopathy DOI Creative Commons
Jingyu Zhang,

Shuangli Chen,

Xiyou Hu

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 17, 2024

Sepsis is a condition that greatly impacts the brain, leading to neurological dysfunction and heightened mortality rates, making it one of primary organs affected. Injury central nervous system can be attributed various throughout entire body imbalances within peripheral immune system. Furthermore, injury create vicious circle with infection-induced disorders. We collate pathogenesis septic encephalopathy, which involves microglial activation, programmed cell death, mitochondrial dysfunction, endoplasmic reticulum stress, neurotransmitter imbalance, blood–brain barrier disruption. also spotlight effects intestinal flora its metabolites, enterocyte-derived exosomes, cholinergic anti-inflammatory pathway, T cells their cytokines on encephalopathy.

Language: Английский

Citations

1
The Sixth Sense: Self-nucleic acid sensing in the brain DOI
Tyler J. Dorrity, Heegwon Shin, Jake A. Gertie

et al.

Advances in immunology, Journal Year: 2024, Volume and Issue: unknown, P. 53 - 83

Published: Jan. 1, 2024

Language: Английский

Citations

1
Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus DOI Creative Commons
G. Maalouly,

Christine-Marie-Anne Martin,

Yara Baz

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 880 - 880

Published: July 22, 2024

Despite accumulating evidence correlating oxidative stress with lupus disease activity, the brain redox pathways are still poorly investigated. Cinnamomum cassia, a widely used spice powerful antioxidant properties, could be novel therapeutic candidate in lupus.

Language: Английский

Citations

1
Effects of miR-722 on gene expression and alternative splicing in the liver of half-smooth tongue sole after infection with Vibrio anguillarum DOI
Hongning Liu, Suxu Tan,

Sen Han

et al.

Fish & Shellfish Immunology, Journal Year: 2023, Volume and Issue: 144, P. 109275 - 109275

Published: Dec. 9, 2023

Language: Английский

Citations

2