The Bidirectional Relationship Between the Gut Microbiome and Mental Health: A Comprehensive Review

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

The gut microbiome plays a fundamental role in mental health, influencing mood, cognition, and emotional regulation through the gut-brain axis. This bidirectional communication system connects gastrointestinal CNS, facilitated by microbial metabolites, neurotransmitters, immune interactions. Recent research highlights association between dysbiosis psychiatric disorders, including anxiety, depression, stress-related conditions. Key findings indicate that altered diversity, decreased short-chain fatty acid (SCFA) production, increased neuroinflammation contribute to health disturbances. paper explores mechanism linking brain function, neurotransmitter synthesis, vagus nerve signaling, hypothalamic-pituitary-adrenal (HPA) axis modulation. Additionally, it evaluates potential of microbiome-targeted interventions, such as probiotics, prebiotics, dietary modifications, fecal microbiota transplantation (FMT), alleviating symptoms. Microbiome sequencing bioinformatics advances further support development personalized microbiome-based interventions. Despite promising evidence, challenges inter-individual variability, methodological inconsistencies, need for longitudinal studies remain. Future should focus on standardizing assessment techniques optimizing therapeutic applications. Integrating precision psychiatry with diagnostics holds immense transforming treatment.

Language: Английский

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Multi-omics Mendelian Randomization Reveals Immunometabolic Signatures of the Gut Microbiota in Optic Neuritis and the Potential Therapeutic Role of Vitamin B6

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Optic neuritis (ON) is an inflammatory condition often linked to autoimmune disorders like multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Despite its low incidence, ON can lead severe, irreversible visual impairment. Emerging evidence suggests the gut microbiota (GM) may influence through complex immune metabolic pathways, yet mechanisms remain underexplored. This study employed a multi-omics Mendelian randomization (MR) approach assess causal relationships between GM taxa ON. We analyzed data from extensive genetic profiling, examining effect 473 taxa, 731 cells/traits, 1400 metabolites, vitamin B6, Our methodology involved two-sample MR analysis establish causality mediation explore potential therapeutic strategies. identified 27 with direct relationship risk. Further highlighted three particularly strong associations. Mediation revealed specific pathways which these exert their effects, including notable interactions B6 metabolism, appeared mediate some of relationships. found that could be method by acting on in advances our understanding etiology highlights as target for The significant role new avenues prevention treatment, emphasizing need further research into diet-based interventions.

Language: Английский

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Exploring the link between gut microbiota and alopecia areata: a two‐sample Mendelian randomization analysis

International Journal of Dermatology, Journal Year: 2024, Volume and Issue: 63(5), P. 597 - 603

Published: Jan. 19, 2024

Abstract Background While observational studies have suggested a link between gut microbiota diversity and alopecia areata (AA), the causal relationship remains unclear. Methods We leveraged data from MiBioGen FinnGen consortiums' Genome‐wide association (GWAS) encompassing ( n = 13,266) AA 211,428) datasets. A comprehensive Mendelian randomization (MR) reverse MR approach were employed, utilizing five statistical methods to evaluate causality. Sensitivity analyses also conducted corroborate results. Results Inverse variance weighted (IVW) analysis indicated protective effect against Butyricimonas (OR 0.37, 95% CI: 0.18–0.77, P 0.01), Enterorhabdus 0.40, 0.16–0.95, 0.04), Eubacterium (xylanophilum group) 0.36, 0.15–0.84, 0.02), Phascolarctobacterium 0.15–0.91, 0.03), while Ruminococcaceae UCG003 posed as risk factor 2.79, 1.27–6.14, 0.01). Reverse showed no significant microbiota, with heterogeneity or horizontal pleiotropy. Conclusions Our suggests probable causality certain AA, shedding light on its pathogenesis potential intervention strategies.

Language: Английский

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Is thyroid function associated with polycystic ovary syndrome? A bidirectional Mendelian randomization study

Endocrine, Journal Year: 2024, Volume and Issue: 85(1), P. 380 - 391

Published: March 12, 2024

Language: Английский

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Correlations between schizophrenia and lichen planus: a two-sample bidirectional Mendelian randomization study

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 13, 2023

Background Several existing studies have shown a correlation between schizophrenia and lichen planus (LP). However, the causality of this relationship remains uncertain. Thus, study aimed to examine causal association LP. Methods A two-sample Mendelian randomization (MR) was carried out investigate whether is causally related LP vice versa, genetic variants in were taken from previous genome-wide studies. We used inverse variance weighted (IVW) method as main analysis. Furthermore, several sensitivity analyses performed assess heterogeneity, horizontal pleiotropy, stability. Results Our results show that has protective effect on (OR = 0.881, 95%CI 0.795–0.975, p 0.015). Conversely, we observed no significant reverse MR analysis 0.934, 0.851–1.026, 0.156). Conclusion supports finds can reduce incidence This contrast findings provides new insights into schizophrenia, but exact mechanism needs further investigation.

Language: Английский

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Microbiota-Short Chain Fatty Acid Relationships and Microbial Substrate Preferences Vary Across the Spectrum of Irritable Bowel Syndrome (IBS)

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

ABSTRACT Background Identifying microbial targets in irritable bowel syndrome (IBS) and other disorders of gut-brain interaction (DGBI) is challenging due to the dynamic nature microbiota-metabolite-host interactions. SCFA are key metabolites that modulate intestinal homeostasis may influence IBS pathophysiology. We aimed assess features associated with short chain fatty acids (SCFA) determine if varied across subtypes endophenotypes. Among 96 participants who were screened, 71 completed study. conducted in-depth investigations stool metagenomes, SCFA, measurable traits (stool bile acids, colonic transit, form) 41 patients (IBS constipation [IBS-C] diarrhea [IBS-D]) 17 healthy controls. used partial canonical correspondence analyses (pCCA), conditioned on quantify microbe-SCFA associations clinical groups. To explore relationships between microbially-derived traits, we compared gut microbiome-encoded potential for substrate utilization groups within a subset selected by their characteristics as well microbiomes without acid malabsorption. Results Overall microbiome composition individual taxa abundances differed Microbes-SCFA revealed including Dorea sp. CAG:317 Bifidobacterium pseudocatenulatum IBS-D Akkermansia muciniphila Prevotella copri IBS-C drive subtype-specific microbially-mediated mechanisms. Strongest observed several SCFA-producing species surprisingly demonstrated inverse correlations SCFA. Fewer bacterial acetate butyrate ratios health. In form, differential genes/pathways metabolism degradation carbohydrates mucin reduced BAM. Conclusion Keystone responsible production differ according subtype characterized functional redundancy. Differences preferences also linked functions. Focusing profiles form be rational strategy identifying relevant DGBI.

Language: Английский

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Effects of immune cells in mediating the relationship between gut microbiota and myelodysplastic syndrome: a bidirectional two-sample, two-step Mendelian randomization study

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 31, 2024

Abstract Background The definitive establishment of a causal relationship between gut microbiota and myelodysplastic syndrome (MDS) has not been achieved. Furthermore, the involvement immune cells in mediating connection MDS is presently unclear. Methods To elucidate bidirectional correlation MDS, as well to investigate role cells, two-sample, two-step Mendelian randomization (MR) study was conducted. Summary statistics were obtained from genome-wide association studies (GWAS), including (456,348 individuals), (18,340 731 signatures (3757 individuals). Results Genetically predicted eight traits significantly associated with risk, but vice versa. Through biological annotation host-microbiome shared genes, we found that regulation may mediate impact on MDS. Subsequently, twenty-three immunophenotypes exhibited significant associations risk five these under influence microbiota. Importantly, effects mediated by immunophenotypes, CD4 + T cell %leukocyte , CD127 CD45RA − regulatory CD45 CD33 HLA DR WHR basophil Monocyte AC . Conclusions Gut causally specific served potential mediators effect Understanding causality among microbiota, critical identifying targets for diagnosis treatment.

Language: Английский

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Exploring causal effects and potential mediating mechanisms of genetically linked environmental senses with intracerebral hemorrhage

Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(9)

Published: Sept. 1, 2024

Abstract The occurrence mechanism of intracerebral hemorrhage remains unclear. Several recent studies have highlighted the close relationship between environmental senses and hemorrhage, but mechanisms causal mediation are inconclusive. We aimed to investigate relationships potential hemorrhage. Multiple Mendelian randomization methods were used identify a Gut microbiota brain imaging phenotypes find possible mediators. Enrichment molecular interaction analyses mediators targets. No temperature visual perception with was found, whereas long-term noise identified as risk factor for (OR 2.95, 95% CI: 1.25 6.93, PIVW = 0.01). gut belonging class Negativicutes order Selenomonadales image–derived ICA100 node 54, edge 803, 1149, 1323 played mediating roles. “Regulation signaling function in synaptic organization” is primary biological pathway noise-induced ARHGAP22 may be critical gene. This study emphasized importance prevention, disease management, underlying

Language: Английский

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Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 27, 2024

Background Several observational studies have indicated an association between interstitial cystitis and the composition of gut microbiota; however, causality underlying mechanisms remain unclear. Understanding link microbiota could inform strategies for prevention treatment. Methods A two-sample Mendelian randomization analysis was conducted using published genome-wide study summary statistics. We employed inverse variance weighted, weighted mode, MR-Egger, median, simple cML-MA methods to investigate causal relationship cystitis. Sensitivity performed validate results. Relevant examined through reverse MR. Single nucleotide polymorphisms were annotated FUMA identify genes associated with these genetic variants, thereby revealing potential host gene-microbiota associations in patients. Results Eight bacterial taxa identified our as Among these, Butyricimonas , Coprococcus Lactobacillales Lentisphaerae Bilophila wadsworthia positively correlated risk, while such Desulfovibrio piger Oscillibacter unclassified Ruminococcus lactaris exhibited protective effects against The robustness confirmed sensitivity analyses. Reverse MR did not reveal evidence causality. subjected biological analysis. Seven hub (SPTBN1, PSME4, CHAC2, ERLEC1, ASB3, STAT5A, STAT3) differentially expressed patients healthy individuals, representing therapeutic targets. Conclusion Our established a Furthermore, identification offers new avenue investigating pathogenesis suggests avenues development personalized treatment strategies.

Language: Английский

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Dajianzhong decoction ameliorated D-gal-induced cognitive aging by triggering mitophagy in vivo and in vitro

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 319, P. 117212 - 117212

Published: Sept. 30, 2023

Language: Английский

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