Journal of Evolutionary Biochemistry and Physiology,
Journal Year:
2024,
Volume and Issue:
60(3), P. 988 - 1002
Published: May 1, 2024
Abstract
Post-traumatic
stress
disorder
(PTSD)
is
a
maladaptive
response
to
the
exposure
of
an
extraordinary-intensity
stressor.
The
animal
and
human
body
responds
any
external
challenges
at
systemic,
organismal
cellular
levels.
In
stress-sensitive
individuals,
collaboration
stress-implementing
stress-limiting
systems
compromised,
causing
transformation
behavior,
cognitive
abilities
other
functions
central
nervous
system.
It
commonly
accepted
now
that
changes
in
abundance
repertoire
intestinal
microbiota
play
important
role
pathogenesis
PTSD.
this
regard,
methods
improving
microflora
are
high
on
agenda.
Analyzing
literature
data,
we
came
conclusion
metabolic,
somatic
mental
health
largely
depends
coordinated
functioning
key
interdependent
metabolic
components:
hepatobiliary
system,
and,
as
believe,
state
mast
cells.
Close
scrutiny
interplay
these
components
will
help
identify
new
therapeutic
targets
most
effective
treat
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 22, 2024
Abstract
A
few
gut
microbiomes
have
been
reported
in
observational
studies
to
be
associated
with
childhood
asthma.
Antibiotic
resistome
of
may
also
influence
asthma
risk.
However,
the
underlying
causal
effect
remains
undefined.
We
attempted
explore
association
these
conditions
through
Mendelian
randomization
(MR)
analysis.
First,
we
review
literatures
identify
core
potentially
The
instrumental
variables
(IVs)
for
microbiome
and
antibiotic
were
obtained
from
MiBioGen
consortium
a
multiomics
study
respectively.
And
genetic
instruments
East
Asian
populations
European
selected
genome-wide
(GWAS).
implemented
Two-sample
MR
analysis
elucidate
on
inverse
variance
weighted
(IVW)
was
employed
as
primary
analysis,
followed
by
heterogeneity
pleiotropy
In
population,
within
microbiomes,
genus
Dialister
significantly
positively
risk
IVW
(OR
=
1.251,
95%
CI
:1.016–1.539,
P
=
0.035).
Moreover,
there
positive
correlation
between
Eubacterium
nodatum
group
1.12,
CI:1.002–1.251,
0.047),
Bilophila
1.29,
CI:1.046–1.581,
0.017)
Conversely,
Holdemanella
0.82,
CI:0.706–0.951,
0.009),
Oxalobacter
0.84,
CI:0.747–0.955,
=0.007)
Slackia
0.81,
CI:0.655–0.996,
0.046)
exhibited
significant
negative
our
revealed
correlations
decreased
order
Actinomycetales
0.390,
:0.173–0.882,
0.024),
family
Actinomycetaceae
0.391,
:0.173–0.883,
0.224),
Actinomyces
0.528,
:0.289–0.965,
0.038),
Fusicatenibacter
0.465,
:0.230–0.938,
0.019).
Coprobacter
showed
1.826,
:1.106–3.016,
0.032).
Finally,
Evenness,
an
index
representing
α-diversity
resistome,
0.825,
CI:0.684–0.994,
0.043).
Conclusions:
This
is
first
employ
validate
identified
literature
try
additional
bacterial
taxes
that
Furthermore,
present
innovatively
explores
pediatric
using
These
findings
provide
opportunities
early
intervention
offer
new
insights
into
mechanisms
further
are
required
generalize
results
future
research.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 27, 2024
Abstract
The
complex
interactions
between
host
genetics
and
the
gut
microbiome
are
well
recognized;
however,
specific
impact
of
gene
expression
pattern
microbial
composition
on
each
other
remains
to
be
further
explored.
Here
we
investigated
this
interplay
within
a
sizable
population
705
hens,
employing
integrative
analyses
examine
relationships
among
genetics,
mucosal
expression,
microbiota.
Specific
taxa
exhibited
strong
adherence
genomic
variants,
particularly
in
cecum
such
as
Christensenellaceae
family
with
heritability
(h
2
)
0.365.
We
proposed
novel
concept
regulatability
(\({r}_{b}^{2}\)),
which
was
derived
from
h
,
quantify
cumulative
effects
given
phenotypes.
duodenal
transcriptome
emerged
potent
influencer
taxa,
exceptionally
higher
\({r}_{b}^{2}\)
values
(0.17
±
0.01,
mean
SE)
compared
(0.02
0.00).
Through
comparative
analysis
chickens
humans,
revealed
similar
average
microbiability
(m
0.18
0.20,
significant
distinctions
vs
0.04).
Notably,
cis
(\({h}_{cis}^{2}\))
quantifies
genetic
variations
proximal
its
while
trans
(\({h}_{trans}^{2}\))
assesses
influence
distant
variations.
Higher
\({h}_{trans}^{2}\)
\({h}_{cis}^{2}\),
greater
prevalence
trans-regulated
genes
over
cis-regulated
ones
underscored
role
loci
outside
cis-window
shaping
levels.
Furthermore,
our
exploration
into
regulation
microbiota
18
traits
enhanced
understanding
their
regulatory
mechanism,
CHST14
Lactobacillus
salivarius
jointly
facilitated
deposition
abdominal
fat.
This
study
has
host-microbe
dynamics,
helps
devise
strategies
modulate
for
improving
economic
chicken.
American Journal of Reproductive Immunology,
Journal Year:
2024,
Volume and Issue:
91(4)
Published: April 1, 2024
Abstract
Purpose
Abnormal
spermatozoa
significantly
impact
reproductive
health,
affecting
fertility
rates,
potentially
prolonging
conception
time,
and
increasing
the
risk
of
miscarriages.
This
study
employs
Mendelian
randomization
to
explore
their
potential
link
with
immune
cells,
aiming
reveal
causal
association
wider
implications
for
health.
Methods
We
conducted
forward
reverse
analyses
connection
between
731
cell
signatures
abnormal
spermatozoa.
Using
publicly
available
genetic
data,
we
investigated
various
such
as
median
fluorescence
intensities
(MFI),
relative
(RC),
absolute
(AC),
morphological
parameters
(MP).
Robustness
was
ensured
through
comprehensive
sensitivity
assessing
consistency,
heterogeneity,
horizontal
pleiotropy.
The
MR
produced
a
statistically
significant
p
‐value
.0000684,
Bonferroni‐corrected
exposures.
Results
analysis
revealed
strong
indications
reciprocal
relationship
pathways
sperm
integrity.
When
examining
exposure,
observed
in
35
different
types
cells.
Conversely,
results
indicated
that
might
causally
affect
39
These
outcomes
suggest
mutual
influence
alterations
functionality
quality
Conclusion
highlights
close
responses
development,
suggesting
health
therapies.
Further
research
may
offer
crucial
insights
into
male
disorders.
Journal of Evolutionary Biochemistry and Physiology,
Journal Year:
2024,
Volume and Issue:
60(3), P. 988 - 1002
Published: May 1, 2024
Abstract
Post-traumatic
stress
disorder
(PTSD)
is
a
maladaptive
response
to
the
exposure
of
an
extraordinary-intensity
stressor.
The
animal
and
human
body
responds
any
external
challenges
at
systemic,
organismal
cellular
levels.
In
stress-sensitive
individuals,
collaboration
stress-implementing
stress-limiting
systems
compromised,
causing
transformation
behavior,
cognitive
abilities
other
functions
central
nervous
system.
It
commonly
accepted
now
that
changes
in
abundance
repertoire
intestinal
microbiota
play
important
role
pathogenesis
PTSD.
this
regard,
methods
improving
microflora
are
high
on
agenda.
Analyzing
literature
data,
we
came
conclusion
metabolic,
somatic
mental
health
largely
depends
coordinated
functioning
key
interdependent
metabolic
components:
hepatobiliary
system,
and,
as
believe,
state
mast
cells.
Close
scrutiny
interplay
these
components
will
help
identify
new
therapeutic
targets
most
effective
treat
