Gynäkologische Endokrinologie, Journal Year: 2023, Volume and Issue: 22(1), P. 75 - 81
Published: Dec. 18, 2023
World Psychiatry, Journal Year: 2025, Volume and Issue: 24(1), P. 52 - 80
Published: Jan. 15, 2025
The understanding of responses to traumatic events has been greatly influenced by the introduction diagnosis post‐traumatic stress disorder (PTSD). In this paper we review initial versions diagnostic criteria for condition and associated epidemiological findings, including sociocultural differences. We consider evidence reactions occurring in multiple contexts not previously defined as traumatic, implications that these observations have diagnosis. More recent developments such DSM‐5 dissociative subtype ICD‐11 complex PTSD are reviewed, adding there several distinct phenotypes. describe psychological foundations PTSD, involving disturbances memory well identity. A broader focus on identity may be able accommodate group communal influences experience trauma impact resource loss. then summarize current concerning biological with a particular genetic neuroimaging studies. Whereas progress prevention disappointing, is now an extensive supporting efficacy variety treatments established trauma‐focused interventions – cognitive behavior therapy (TF‐CBT) eye movement desensitization reprocessing (EMDR) non‐trauma‐focused therapies, which also include some emerging identity‐based approaches present‐centered compassion‐focused therapies. Additionally, promising neither nor pharmacological, or combine pharmacological approach, 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy. advances priority areas adapting resource‐limited settings across cultural contexts, community‐based approaches. conclude identifying future directions work mental health.
Language: Английский
Citations
10
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 41, P. 100849 - 100849
Published: Aug. 23, 2024
Language: Английский
Citations
8
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: June 3, 2024
This mini-review explores the role of short-chain fatty acids (SCFAs) in posttraumatic stress disorder (PTSD). Highlighting microbiota-gut-brain axis, this study investigated bidirectional communication between gut microbiome and mental health. SCFAs, byproducts microbial fermentation, have been examined for their potential impact on PTSD, with a focus molecular mechanisms therapeutic interventions. review discusses changes SCFA levels bacterial profiles individuals emphasizing need further research. Promising outcomes from clinical trials using probiotics fermented formulations suggest avenues PTSD management. Future directions involve establishing comprehensive human cohorts, integrating multiomics data, employing advanced computational methods, goal deepening our understanding SCFAs exploring microbiota-targeted
Language: Английский
Citations
7
Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 184, P. 27 - 38
Published: Feb. 21, 2025
Language: Английский
Citations
0
Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19
Published: Feb. 24, 2025
Post-traumatic stress disorder (PTSD) is a common mental health that can occur following exposure to traumatic event, and characterized by symptoms including intrusive memories, dissociation, nightmares. PTSD poses significant suffering on the individual reduce quality of life substantially, however, its mechanisms are not fully understood. It has also been associated with gut abnormalities, such as irritable bowel syndrome, indicating possible involvement microbiome gut-brain axis. Whereas previous research implicated axis in various disorders, relationship between function unclear. Specifically, little known about whether specific compositions increase risk developing PTSD, or, vice versa, act protective factor for individual. This systematic review aims synthesize literature looking at differences individuals trauma-exposed controls (TEC) while exploring potential resilience factors development disorder. Three studies met inclusion criteria, results showed all found microbial taxa TEC groups yet varied their taxonomic level type. One study difference diversity groups, reporting lower two certain be correlated symptom severity: Mitsuokella, Odoribacter, Catenibacterium Olsenella genera, Actinobacteria, Lentisphaerae Verrucomicrobia phyla. important implications novel treatments which target microbiome, example psychobiotic dietary interventions prebiotics probiotics. informs our understanding disorder, being potentially or increasing susceptibility. More needed, currently sample sizes small confounding variables (e.g., diet) always controlled for. Systematic registration: The protocol was registered PROSPERO, registration number: CRD42024530033.
Language: Английский
Citations
0
Cureus, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
The gut microbiome plays a fundamental role in mental health, influencing mood, cognition, and emotional regulation through the gut-brain axis. This bidirectional communication system connects gastrointestinal CNS, facilitated by microbial metabolites, neurotransmitters, immune interactions. Recent research highlights association between dysbiosis psychiatric disorders, including anxiety, depression, stress-related conditions. Key findings indicate that altered diversity, decreased short-chain fatty acid (SCFA) production, increased neuroinflammation contribute to health disturbances. paper explores mechanism linking brain function, neurotransmitter synthesis, vagus nerve signaling, hypothalamic-pituitary-adrenal (HPA) axis modulation. Additionally, it evaluates potential of microbiome-targeted interventions, such as probiotics, prebiotics, dietary modifications, fecal microbiota transplantation (FMT), alleviating symptoms. Microbiome sequencing bioinformatics advances further support development personalized microbiome-based interventions. Despite promising evidence, challenges inter-individual variability, methodological inconsistencies, need for longitudinal studies remain. Future should focus on standardizing assessment techniques optimizing therapeutic applications. Integrating precision psychiatry with diagnostics holds immense transforming treatment.
Language: Английский
Citations
0
Neuroscience and Behavioral Physiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 14, 2025
Language: Английский
Citations
0
Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: 128, P. 540 - 548
Published: April 25, 2025
Language: Английский
Citations
0
Medicine, Journal Year: 2025, Volume and Issue: 104(20), P. e42423 - e42423
Published: May 16, 2025
Post-traumatic stress disorder (PTSD) and Attention deficit hyperactivity (ADHD) are common mental illnesses. Observational studies have indicated that these conditions often co-occur with gastrointestinal diseases. However, the causal relationship between PTSD ADHD diseases remain unclear. We conducted Mendelian randomization (MR) analysis to investigate associations. selected genetic instrument data genome-wide significance levels for from psychiatric genomics consortium open association study platform. Summary statistics 24 were obtained FinnGen study. used "TwoSampleMR" package in R perform a 2-sample MR sensitivity of results. found susceptibility was associated 1 disease, specifically pancreatic cancer (P = .003; odds ratios [OR] 1.295; 95% CI, 1.094-1.531). Genetic 4 diseases: gastroesophageal reflux .014; OR 1.100; 1.020-1.186), gastric ulcer .004; 1.208; 1.061-1.376), duodenal .020; 1.206; 1.029-1.413), chronic gastritis .021; 1.122; 1.018-1.237). This provides evidence supporting specific
Language: Английский
Citations
0