Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 31, 2024
Schizophrenia (SZ) is a severe mental disorder with complex origins. Observational studies suggested that inflammatory factors may play role in the pathophysiology of SZ and we aim to investigate potential genetic connection between them by examining causal impact circulating proteins on SZ.
Language: Английский
Psychological Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10
Published: Jan. 6, 2025
Childhood trauma (CT) is related to altered fractional anisotropy (FA) in individuals with schizophrenia (SZ). However, it remains unclear whether CT may influence specific cellular or extracellular compartments of FA SZ experience. We extended our previous study on (Costello et al., 2023) and examined the impact hypothesized lower free water-corrected (FA
Language: Английский
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Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Psychotic disorders are characterized by white matter (WM) abnormalities; however, their relationship with the various aspects of illness presentation remains unclear. Sleep disturbances common in psychosis, and emerging evidence suggests that sleep plays a critical role WM physiology. Therefore, it is plausible associated impaired integrity these disorders. To test this hypothesis, we examined association self-reported transverse (T2) relaxation times cross-diagnostic sample patients psychosis. A total 28 psychosis (11 schizophrenia spectrum 17 bipolar disorder psychotic features) were included. Metabolite (N-acetyl aspartate, choline, creatine) water T2 measured anterior corona radiata at 4T. was evaluated using Pittsburgh Quality Index (PSQI). PSQI score showed moderate to strong positive correlation (r = 0.64, p< 0.001). Linear regressions independent overall severity depressive, manic, or symptoms. In our exploratory analysis, disturbance correlated free percentage, suggesting increased extracellular may be mechanism underlying disturbed prolonged relaxation. Our results highlight connection between poor abnormalities Future research objective measures neuroimaging techniques suitable probe needed further insight into relationship.
Language: Английский
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NeuroSci, Journal Year: 2025, Volume and Issue: 6(1), P. 8 - 8
Published: Jan. 18, 2025
Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and Alzheimer’s disease. Differentiating early MCI (EMCI) from late (LMCI) crucial for diagnosis intervention. This study used free-water diffusion tensor imaging (fw-DTI) to investigate white matter differences voxel-based correlations with Mini–Mental State Examination (MMSE) scores. Data the Disease Neuroimaging Initiative included 476 healthy controls (CN), 137 EMCI participants, 62 LMCI participants. Significant MMSE were found CN groups, but not LMCI. However, distinct changes observed: showed higher f-index lower fw-fractional anisotropy (fw-FA) compared in several regions. These findings indicate specific tracts involved progression. Voxel-based fw-DTI metrics scores further supported these results. In conclusion, this provides insights into associated LMCI, offering significant implications future research clinical practice.
Language: Английский
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Schizophrenia Bulletin, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 22, 2025
Abstract Background and Hypothesis Identifying biomarkers at onset specifying the progression over early course of schizophrenia is critical for better understanding illness pathophysiology providing novel information relevant to prognosis treatment selection. Studies antipsychotic-naïve first-episode in China are making contributions this goal. Study Design A review was conducted how patients were identified studied, investigated biological measures, with a focus on neuroimaging, they extend regarding illness-related brain abnormality, effect characterization outcome prediction, subtype discovery patient stratification, comparison findings from western populations. Finally, biomarker studies should be future also discussed. Results Gray matter reduction has been most robust within temporo-frontal regions cerebellum, whereas altered function pronounced cerebello-cortical connections default mode network, each might related long-standing alterations acute physiological measurement. By studying untreated patients, progressive temporal frontal enlargements bilateral putamen found more likely effects illness, not just treatment. Some these changes potential predict clinical outcomes differentiate biologically subgroups. Conclusions Mostly data-driven approaches, helping identify candidate imaging that early-stage effects, subgroup differentiation. Future work needed translate application.
Language: Английский
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The Journal of Headache and Pain, Journal Year: 2025, Volume and Issue: 26(1)
Published: Feb. 12, 2025
To assess the effect of modeling free water (FW) on identification white matter (WM) microstructure alterations using diffusion Magnetic Resonance Imaging (dMRI) in episodic migraine without aura patients compared with healthy controls. Diffusion tensor imaging (DTI) studies examining WM previously overlooked potential influence FW partial volume effects. Correcting effects could offer a clearer understanding changes migraine. This study is first to incorporate when evaluating tracts patients, offering comparison standard DTI analysis. A group 14 low-frequency menstrual-related and 15 controls matched for phase menstrual cycle were recruited underwent dMRI acquisitions. fraction was estimated, signal corrected parameters calculated from both FW-corrected uncorrected signals. Tract-Based Spatial Statistics (TBSS) skeleton regions interest (ROI) analyses used compare between groups. Comparisons control subjects TBSS ROI revealed significantly lower axial diffusivity (AD), correction, as well altered values some tracts. detected MD only after correction. These findings suggest these subjects, accordance other studies. Differences might point inflammatory processes related cellular swelling.
Language: Английский
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Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 277 - 291
Published: Jan. 1, 2025
Language: Английский
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Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
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Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 119, P. 709 - 712
Published: April 24, 2024
Language: Английский
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bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 5, 2024
Background Schizophrenia (SZ) and bipolar disorder (BD) are characterized by white matter (WM) abnormalities, however, their relationship with illness presentation is not clear. Sleep disturbances common in both disorders, recent evidence suggests that sleep plays a critical role WM physiology. Therefore, it plausible associated impaired integrity these disorders. To test this hypothesis, we examined the association of self-reported transverse (T2) relaxation times patients SZ spectrum disorders BD psychotic features. Methods 28 psychosis (17 BD-I, features 11 disorders) were included. Metabolite water T2 measured anterior corona radiata at 4T. was evaluated using Pittsburgh Quality Index. Results PSQI total score showed moderate to strong positive correlation (r = 0.64, p<0.001). Linear regressions specific disturbance but byproduct exacerbation depressive, manic, or symptoms. In our exploratory analysis, correlated free percentage, suggesting increased extracellular may be mechanism underlying disturbed prolonged relaxation. Conclusion Our results highlight connection between poor abnormalities Future research objective measures neuroimaging techniques suitable probe needed further insight into relationship.
Language: Английский
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Cerebral Cortex, Journal Year: 2024, Volume and Issue: 34(7)
Published: July 1, 2024
The hippocampus is one of the brain regions most vulnerable to inflammatory insults, and relationships between peripheral inflammation hippocampal subfields in patients with schizophrenia remain unclear. In this study, forty-six stably medicated 48 demographically matched healthy controls (HCs) were recruited. serum levels IL - 1β, IL-6, IL-10, IL-12p70 measured, 3D high-resolution T1-weighted magnetic resonance imaging was performed. subfield volumes both compared HCs. associations altered assessed patients. Patients demonstrated higher IL-6 IL-10 but lower than patients, positively correlated left granule cell layer dentate gyrus (GCL) cornu Ammonis (CA) 4, while negatively those subfields. might have antagonistic roles atrophy GCL CA4. This suggests a complexity cytokine dysregulation potential for its selective effects on substructures, which be related pathophysiology schizophrenia.
Language: Английский
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