Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation DOI Creative Commons
Raana A. Mohyee, Blake L. Elliott, Madeline Pike

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the effects of prenatal (PNMI) on microstructure humans remains unclear. Here, we examined relationship between PNMI neurite density hippocampus its subfields among during late middle age. Participants included 72 mother-offspring dyads from Child Health Development Studies (CHDS) cohort. Data for four inflammatory biomarkers (IL-6, IL-8, IL-1 receptor antagonist [IL-1RA], soluble TNF receptor-II [sTNF-RII]) were available first second trimester sera. Neurite was estimated using microstructural modeling offsprings’ diffusion-weighted Magnetic Resonance Imaging data (mean age at imaging = 59 years; 51% male). We each biomarker region-of-interest’s Higher IL-1RA IL-6 levels lower These relationships specific CA3, CA4, dentate gyrus, subiculum subfields. addition, higher Our findings reveal that linked age, which could have implications memory decreases this period may be relevant understanding risk aging-related cognitive changes. Significance Statement The contribution brain later life well established but poorly understood humans. study discovered long-lasting impacts elevated early-mid gestation structural integrity underscore potential role developmental programming neurological decline, as observed degradation present over half a century following exposure.

Language: Английский

Neuroinflammation and mental health outcomes in adolescents living with HIV DOI
Arish Mudra Rakshasa-Loots, Jaime H. Vera, Barbara Laughton

et al.

Current Opinion in HIV and AIDS, Journal Year: 2024, Volume and Issue: 19(6), P. 355 - 360

Published: July 10, 2024

Adolescents living with HIV show chronic inflammation, which in turn has been linked to mental health outcomes the general population. The increased risk for issues adolescents may thus be driven by HIV-related inflammation. In this review, we discuss associations between peripheral and central nervous system inflammation HIV.

Language: Английский

Citations

3
Association between psychiatric symptoms with multiple peripheral blood sample test: a 10-year retrospective study DOI Creative Commons
Jianqing Qiu, Chenghao Yu,

Yalan Kuang

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 9, 2024

Psychiatric illness is thought to be a brain somatic crosstalk disorder. However, the existing phenomenology-based Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic framework overlooks various dimensions other than symptoms. In this study, we investigated associations between peripheral blood test indexes with symptom levels major depressive disorder (MDD), bipolar (BD), schizophrenia (SCZ) explore availability indexes.

Language: Английский

Citations

1
Decreased hippocampal neurite density in middle-aged/aging adults following prenatal exposure to higher levels of maternal inflammation DOI Creative Commons
Raana A. Mohyee, Blake L. Elliott, Madeline Pike

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the effects of prenatal (PNMI) on microstructure humans remains unclear. Here, we examined relationship between PNMI neurite density hippocampus its subfields among during late middle age. Participants included 72 mother-offspring dyads from Child Health Development Studies (CHDS) cohort. Data for four inflammatory biomarkers (IL-6, IL-8, IL-1 receptor antagonist [IL-1RA], soluble TNF receptor-II [sTNF-RII]) were available first second trimester sera. Neurite was estimated using microstructural modeling offsprings’ diffusion-weighted Magnetic Resonance Imaging data (mean age at imaging = 59 years; 51% male). We each biomarker region-of-interest’s Higher IL-1RA IL-6 levels lower These relationships specific CA3, CA4, dentate gyrus, subiculum subfields. addition, higher Our findings reveal that linked age, which could have implications memory decreases this period may be relevant understanding risk aging-related cognitive changes. Significance Statement The contribution brain later life well established but poorly understood humans. study discovered long-lasting impacts elevated early-mid gestation structural integrity underscore potential role developmental programming neurological decline, as observed degradation present over half a century following exposure.

Language: Английский

Citations

0