Alterations in Gut Microbiota Composition Are Associated with Changes in Emotional Distress in Children with Obstructive Sleep Apnea DOI Creative Commons
Chung‐Guei Huang, Wan‐Ni Lin, Li‐Jen Hsin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2626 - 2626

Published: Dec. 18, 2024

Emerging evidence underscores the pivotal role of gut microbiota in regulating emotional and behavioral responses via microbiota–gut–brain axis. This study explores associations between pediatric obstructive sleep apnea (OSA), distress (ED), microbiome alterations before after OSA treatment. Sixty-six children diagnosed with polysomnography participated, undergoing adenotonsillectomy alongside routine educational sessions. ED was assessed using OSA-18 questionnaire, categorizing participants into high (scores ≥ 11, 52%) low < 48%) groups. Gut analysis revealed significant diversity differences, linked to a reduced Shannon index (p = 0.03) increased beta 0.01). Three months post-treatment, improvements were observed symptoms, scores, alpha metrics among 55 (all p 0.04). Moreover, changes relative abundances Veillonella, Bifidobacterium, Flavonifractor, Agathobacter, as well ultra-low frequency power heart rate variability, independently associated score alterations. These findings underscore microbiome’s critical symptoms OSA, suggesting that microbiome-targeted interventions could complement traditional treatments for reduction emphasizing need further research.

Language: Английский

Effect of ultra-processed food consumption on the gut microbiota in the first year of life: findings from the MINA-Brazil birth cohort study DOI
Lucas Damasio Faggiani,

Paula de França,

Sofia G. Seabra

et al.

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 46, P. 181 - 190

Published: Feb. 6, 2025

Language: Английский

Citations

0
Global research trends in the intestinal microflora and depression: bibliometrics and visual analysis DOI Creative Commons
Qian Xu,

Qingwei Xiang,

Zihu Tan

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 25, 2025

In recent years, the relationship between gut microbiota and human health has garnered significant attention. Notably, potential connection mental issues, such as depression anxiety, emerged a new focal point for research. While some studies suggest possible link these factors, field remains in its early stages of development, there are notable methodological sample size limitations. This study aims to systematically summarize knowledge systems, research hotspots, development trends related intestinal microflora within context conducted search publications Web Science Core Collection (WOSCC) prior August 6, 2024. The selected literature was subsequently analyzed using VOSviewer (v.1.6.20), SCImago Graphica (v.1.0.39), CiteSpace (v.6.3.1). encompassed total 1,046 publications, demonstrating consistent increase annual publication volume. primary countries identified China United States, with contributions from institutions University California College Cork, among others. Keywords analysis highlighted high-frequency terms including "gut microbiota," "depression," "anxiety," revealed 10 keyword clusters along 20 strongest citation bursts keywords. focus shifted compositional role pathogenesis depression. Research on is growing, but still need greater collaboration authors across regions, more ongoing interaction communication further explore mechanisms action microbiota, develop microbiota-based interventions, facilitate translation findings into clinical practice.

Language: Английский

Citations

0
The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Citations

0
Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy DOI
Sepideh Khoshnevis, Michael H. Smolensky, Shahab Haghayegh

et al.

Advanced Drug Delivery Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 115576 - 115576

Published: April 1, 2025

Language: Английский

Citations

0
The gut-microbiome in adult Attention-deficit/hyperactivity disorder - A Meta-analysis DOI Creative Commons
Babette Jakobi, Priscilla Vlaming, Danique Mulder

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 88, P. 21 - 29

Published: Aug. 8, 2024

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that persists into adulthood in the majority of individuals. While gut-microbiome seems to be relevant for ADHD, few publications on gut-microbial alterations ADHD are inconsistent, investigated phenotypes, sequencing method/region, preprocessing, statistical approaches, and findings. To identify adult robust across studies we harmonized bioinformatic pipelines analyses raw 16S rRNA data from four case-control (N

Language: Английский

Citations

2
Microbiota-Short Chain Fatty Acid Relationships and Microbial Substrate Preferences Vary Across the Spectrum of Irritable Bowel Syndrome (IBS) DOI Open Access
Andrea Shin, Yue Xing,

Mohammed Rayyan Waseem

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

ABSTRACT Background Identifying microbial targets in irritable bowel syndrome (IBS) and other disorders of gut-brain interaction (DGBI) is challenging due to the dynamic nature microbiota-metabolite-host interactions. SCFA are key metabolites that modulate intestinal homeostasis may influence IBS pathophysiology. We aimed assess features associated with short chain fatty acids (SCFA) determine if varied across subtypes endophenotypes. Among 96 participants who were screened, 71 completed study. conducted in-depth investigations stool metagenomes, SCFA, measurable traits (stool bile acids, colonic transit, form) 41 patients (IBS constipation [IBS-C] diarrhea [IBS-D]) 17 healthy controls. used partial canonical correspondence analyses (pCCA), conditioned on quantify microbe-SCFA associations clinical groups. To explore relationships between microbially-derived traits, we compared gut microbiome-encoded potential for substrate utilization groups within a subset selected by their characteristics as well microbiomes without acid malabsorption. Results Overall microbiome composition individual taxa abundances differed Microbes-SCFA revealed including Dorea sp. CAG:317 Bifidobacterium pseudocatenulatum IBS-D Akkermansia muciniphila Prevotella copri IBS-C drive subtype-specific microbially-mediated mechanisms. Strongest observed several SCFA-producing species surprisingly demonstrated inverse correlations SCFA. Fewer bacterial acetate butyrate ratios health. In form, differential genes/pathways metabolism degradation carbohydrates mucin reduced BAM. Conclusion Keystone responsible production differ according subtype characterized functional redundancy. Differences preferences also linked functions. Focusing profiles form be rational strategy identifying relevant DGBI.

Language: Английский

Citations

1
Alterations in Gut Microbiota Composition Are Associated with Changes in Emotional Distress in Children with Obstructive Sleep Apnea DOI Creative Commons
Chung‐Guei Huang, Wan‐Ni Lin, Li‐Jen Hsin

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2626 - 2626

Published: Dec. 18, 2024

Emerging evidence underscores the pivotal role of gut microbiota in regulating emotional and behavioral responses via microbiota–gut–brain axis. This study explores associations between pediatric obstructive sleep apnea (OSA), distress (ED), microbiome alterations before after OSA treatment. Sixty-six children diagnosed with polysomnography participated, undergoing adenotonsillectomy alongside routine educational sessions. ED was assessed using OSA-18 questionnaire, categorizing participants into high (scores ≥ 11, 52%) low < 48%) groups. Gut analysis revealed significant diversity differences, linked to a reduced Shannon index (p = 0.03) increased beta 0.01). Three months post-treatment, improvements were observed symptoms, scores, alpha metrics among 55 (all p 0.04). Moreover, changes relative abundances Veillonella, Bifidobacterium, Flavonifractor, Agathobacter, as well ultra-low frequency power heart rate variability, independently associated score alterations. These findings underscore microbiome’s critical symptoms OSA, suggesting that microbiome-targeted interventions could complement traditional treatments for reduction emphasizing need further research.

Language: Английский

Citations

1