Tidsskrift for Norsk psykologforening,
Journal Year:
2024,
Volume and Issue:
61(12), P. 829 - 842
Published: Nov. 28, 2024
Bullying,
physical
violence,
sexual
abuse,
loss
of
loved
ones,
accidents,
disasters
or
other
potentially
traumatic
events
situations
in
childhood
are
associated
with
a
range
health
problems
and
related
functional
impairment.
New
research
findings
suggest
that
such
trauma
can
lead
to
young
people
developing
chronic
pain
frequent
use
painkillers
already
adolescence.
The
high
risk
adverse
trajectories
may
indicate
who
develop
after
lack
access
early
effective
interventions.
Trauma-exposed
children
long-term
accompanying
post-traumatic
reactions
benefit
little
from
established
management.
Knowledge
risk,
resiliency
key
mechanisms
following
strengthen
clinical
This
review
article
explores
theoretical
empirical
perspectives
on
how
biological,
psychological
social
factors
contribute
the
development
among
adolescents.
Keywords:
Childhood
trauma,
posttraumatic
stress,
pain,
PTSD,
analgesics
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 6, 2025
Major
depressive
disorder
(MDD)
in
adolescents
poses
a
significant
threat
to
physical
health.
Previous
studies
have
indicated
that
with
MDD
exhibit
immune
activation.
This
study
aimed
compare
cytokine
levels
healthy
controls
and
assess
their
diagnostic
value.
cross-sectional
included
58
adolescent
patients
depression
from
Beijing
Anding
Hospital
(outpatients
inpatients)
40
recruited
the
community.
Multiplex
analysis
(Luminex
xMAP)
was
used
measure
serum
of
several
cytokines.
Data
performed
using
SPSS
(version
26.0)
between
gender
differences.
Correlations
demographic
data,
clinical
features
symptoms
were
also
analyzed.
The
receiver
operating
characteristic
(ROC)
curves
evaluate
value
Serum
IL-4,
IFN-γ,
TNF-α
significantly
elevated
group
compared
(p
<
0.05).
In
group,
age
first
onset
females
younger
than
males
0.05),
female
higher
those
BMI
IL-4
positively
correlated
MDD.
area
under
ROC
curve
for
diagnosing
0.695
(95%
confidence
interval
[CI]:
0.580
-
0.809;
p
sensitivity
0.793
specificity
0.675.
Compared
controls,
demonstrated
levels,
indicating
activation
which
female.
Cytokines
may
promising
depression,
but
further
validation
additional
indicators
is
needed.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
This
study
investigates
the
therapeutic
effectiveness
of
intranasal
dantrolene
nanoparticles
pretreatment
to
inhibit
lipopolysaccharide
(LPS)-induced
pathological
inflammation
and
synapse
destruction
depressive
anxiety
behavior
in
mice.
B6SJLF1/J
adult
mice
were
pretreated
with
(dantrolene:
5mg/kg),
daily,
Monday
Friday,
5
days
per
week,
for
4
weeks.
Then,
treated
an
intraperitoneal
injection
LPS
(5mg/kg)
one
time.
Behavioral
tests
depression
performed
24
hours
after
a
one-time
injection.
Biomarkers
pyroptosis-related
cytokines
(IL-1β
IL-18)
blood
brain
measured
using
enzyme-linked
immunosorbent
assay
(ELISA)
immunoblotting,
respectively.
The
changes
primary
proteins
activation
inflammatory
pyroptosis
(NLRP3:
NLR
family
pyrin
domain
containing
3,
Caspase-1,
N-GSDMD:
N
terminal
protein
gasdermin
D)
(PSD-95
synpatin-1)
brains
immunoblotting.
Intranasal
robustly
inhibited
LPS-induced
behavior.
significantly
elevation
IL-1β
IL-18
pyroptosis.
ameliorated
decrease
PSD-95
synpatin-1
brains.
Thus,
have
demonstrated
neuroprotection
against
inflammation-mediated
behaviors
should
be
studied
further
as
future
effective
drug
treatment
major
disorder
or
psychiatric
disorder.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 3, 2025
Previous
evidence
suggests
that
immune-inflammatory
dysfunction
plays
an
important
role
in
metabolic
disorder
(MD)
of
patients
with
schizophrenia,
yet
studies
on
sex
differences
the
association
between
both
are
limited.
The
current
study
aimed
to
investigate
MD
and
inflammatory
cytokines
Han
Chinese
chronic
schizophrenia
(CS).
This
multicentre
cross-sectional
was
conducted
one
general
hospital
two
psychiatric
hospitals
Anhui
Province,
China.
General
information,
parameters
cytokine
indicators
were
collected
from
all
participants,
severity
their
symptoms
assessed
using
Positive
Negative
Syndrome
Scale
(PANSS).
A
total
324
completed
assessment
included
this
study.
had
higher
age
duration
illness,
lower
chlorpromazine
equivalents
negative
symptom
score
than
those
without
MD.
Binary
logistic
regression
showed
significantly
associated
a
IL-1β
level
male
patients,
while
not
significant
females.
Further
multiple
linear
revealed
negatively
correlated
polypharmacy
only
patients.
Sex
CS,
is
there
correlation
level.
Sex-specific
prevention
intervention
strategies
may
contribute
reducing
CS.
Frontiers in Psychiatry,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 7, 2025
Inadequate
pain
management
not
only
results
in
prolonged
physical
discomfort
but
also
causes
a
range
of
psychological
and
social
issues,
such
as
anxiety,
depression,
withdrawal,
diminished
work
performance.
This
study
aims
to
investigate
the
relationship
between
duration
depression.
utilized
data
on
depression
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2011
2014.
Participants
with
health
questionnaire
score
≥10
were
considered
have
depressive
symptoms.
Weighted
univariate,
multivariate
logistic
regression
analysis,
sensitivity
restricted
cubic
spline
(RCS)
analysis
used
examine
risk
Additionally,
subgroup
was
conducted
identify
potential
confounding
factors
that
might
affect
this
relationship.
Among
2,248
participants,
442
(19.6%)
diagnosed
symptoms,
an
average
age
52
years,
69%
whom
female.
After
adjusting
for
all
factors,
our
show
significant
association
(in
months)
Individuals
highest
quartile
had
154%
higher
likelihood
developing
compared
those
lowest
(OR
=
3.375,
95%
CI
2.329-4.886,
P
<
0.001),
trend
test
(P
0.001).
The
RCS
indicated
linear
nonlinearity
0.427).
study's
indicate
inadequate
control,
resulting
extended
duration,
places
patients
at
Journal of Pain Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1313 - 1323
Published: March 1, 2025
Poor
pain
control
may
lead
to
persistent
physical
discomfort
and
even
reduced
perceptual
abilities.
This
research
seeks
investigate
the
relationship
between
status
duration
sensory
impairments.
study
used
data
on
impairments
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2011
2014,
including
8043
participants.
Functional
of
vision,
hearing,
smell,
taste
was
gathered
using
structured
questionnaires.
Logistic
regression
models
were
evaluate
association
status,
duration,
total
number
specific
deficits,
while
adjusting
for
key
covariates
such
as
age,
gender,
BMI,
socioeconomic
status.
Stratified
analysis
performed
determine
factors
that
might
confound
this
relationship.
The
multivariable-adjusted
model
showed
individuals
with
1
3
years
had
a
64%
increased
risk
impairment
compared
those
without
(OR
1.640,
95%
CI
1.132-2.376,
P
=
0.016),
over
90.9%
1.909,
1.472-2.475,
0.001).
We
also
found
statistically
significant
≥
year
visual
1.841,
1.252-2.705,
<
0.01).
Furthermore,
participants
>
significantly
associated
olfactory
2.264,
1.538-3.331,
0.001)
2.070,
1.335-3.209,
However,
no
observed
hearing
in
any
category.
results
suggest
longer
chronic
are
at
higher
impairments,
particularly
visual,
olfactory,
Timely
effective
management
help
reduce
long-term
Open Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
This
study
aims
to
explore
the
current
status
of
depression
and
related
factors
in
middle-aged
elderly
people
China
using
a
cohort
database
with
multi-year
follow-up.
The
population
for
this
project
was
derived
from
Health
Retirement
Longitudinal
Study.
Participants
were
divided
into
control
groups
based
on
scores
Center
Epidemiological
Research
Depression
Scale.
Continuous
variables
compared
t-tests
or
Mann-Whitney
U
tests,
while
categorical
chi-square
tests.
A
multivariate
logistic
regression
model
employed
evaluate
associated
depression.
total
9,749
participants
included
study.
Correlation
analyses
revealed
that
age,
body
mass
index,
diastolic
blood
pressure,
waist
circumference,
cholesterol,
uric
acid,
length
sleep
significantly
(p
<
0.05).
Women
exhibited
higher
risk
middle
old
age
men
An
increase
circumference
decreased
Longer
duration
educational
levels
also
reduced
Unfavorable
marital
frequency
alcohol
consumption
found
In
individuals,
women,
low
education
level,
experiencing
dissatisfaction
marriage
are
connected
high
On
other
hand,
increased
moderate
consumption,
longer
