Microglia: The Drunken Gardeners of Early Adversity DOI Creative Commons
Sahabuddin Ahmed, Baruh Polis, Arie Kaffman

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 964 - 964

Published: Aug. 8, 2024

Early life adversity (ELA) is a heterogeneous group of negative childhood experiences that can lead to abnormal brain development and more severe psychiatric, neurological, medical conditions in adulthood. According the immune hypothesis, ELA leads an response characterized by high levels inflammatory cytokines. This contributes health outcomes refractory treatment individuals with history ELA. Here, we examine this hypothesis context recent rodent studies focus on impact microglia, resident cells brain. We review progress our ability mechanistically link molecular alterations microglial function during critical period changes synaptic connectivity, cognition, stress reactivity later life. also research showing induces long-term "secondary hits" such as traumatic injury, substance use, exposure additional conclude discussion future directions unresolved questions regarding signals modify clinical significance for humans.

Language: Английский

Hormonal contraceptives in adolescence impact the neuroimmune environment of the medial prefrontal cortex and hippocampus in female rats DOI
Rachel A Gilfarb, Sourabh Ranade,

Elizabeth Dybas

et al.

Brain Behavior and Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Autism-associated ASPM variant causes macrocephaly and social-cognitive deficits in mice DOI Open Access
Sarika Singh, Hyopil Kim, Alev Ecevitoglu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

ABSTRACT In autism spectrum disorder (ASD), a neurodevelopmental with social-cognitive deficits, macrocephaly occurs in 20% of patients severe symptoms. However, the role ASD pathogenesis remains unclear. Here, we address mechanistic link between and by investigating novel ASD-associated gain-of-function A1877T mutation ASPM ( abnormal spindle-like microcephaly-associated ). is key regulator cortical size cell proliferation expressed both excitatory inhibitory neuronal progenitors but not differentiated neurons. We found that Aspm knock-in mice exhibit macrocephaly, excessive embryonic neurogenesis expanded outer radial glia, an increased excitatory-inhibitory (E-I) ratio, brain hyperconnectivity, deficits male specificity. Our results suggest proportional expansion neurons, shift E-I independent expression patterns causative gene. Thus, alone can cause subset ASD-like

Language: Английский

Citations

0
Potential roles for microglia in drug addiction: Adolescent neurodevelopment and beyond DOI
Maricela X. Martinez, Stephen V. Mahler

Journal of Neuroimmunology, Journal Year: 2025, Volume and Issue: unknown, P. 578600 - 578600

Published: March 1, 2025

Language: Английский

Citations

0
Stress-induced dysfunction of neurovascular astrocytes in the prefrontal cortex contributes to sex-dependent deficits in cognition and behavior DOI Creative Commons
Justin L. Bollinger,

Shobha Johnsamuel,

Lauren L. Vollmer

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
Microglia: The Drunken Gardeners of Early Adversity DOI Creative Commons
Sahabuddin Ahmed, Baruh Polis, Arie Kaffman

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 964 - 964

Published: Aug. 8, 2024

Early life adversity (ELA) is a heterogeneous group of negative childhood experiences that can lead to abnormal brain development and more severe psychiatric, neurological, medical conditions in adulthood. According the immune hypothesis, ELA leads an response characterized by high levels inflammatory cytokines. This contributes health outcomes refractory treatment individuals with history ELA. Here, we examine this hypothesis context recent rodent studies focus on impact microglia, resident cells brain. We review progress our ability mechanistically link molecular alterations microglial function during critical period changes synaptic connectivity, cognition, stress reactivity later life. also research showing induces long-term "secondary hits" such as traumatic injury, substance use, exposure additional conclude discussion future directions unresolved questions regarding signals modify clinical significance for humans.

Language: Английский

Citations

0